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Mutated channelopathy due to the activation of calcium channels has been recently described in aldosterone-producing adenoma (APA). The study involved 148 consecutive PA patients, (66 males; aged 56.3\u2009\u00b1\u200912.3years) who received adrenalectomy and were collected from the Taiwan PA investigator (TAIPAI) group. A high rate of somatic mutation in APA was found (n\u2009=\u200991, 61.5%); including mutations in <jats:italic>KCNJ5<\/jats:italic> (n\u2009=\u200988, 59.5%), <jats:italic>ATP1A1<\/jats:italic> (n\u2009=\u20092, 1.4%) and <jats:italic>ATP2B3<\/jats:italic> (n\u2009=\u20091, 0.7%); however, no mutations in <jats:italic>CACNA1D<\/jats:italic> were identified. Mutation-carriers were younger (&lt;0.001), had lower Cyst C (p\u2009=\u20090.042), pulse wave velocity (p\u2009=\u20090.027), C-reactive protein (p\u2009=\u20090.042) and a lower rate of proteinuria (p\u2009=\u20090.031) than non-carriers. After multivariate adjustment, mutation carriers had lower serum CRP levels than non-carriers (p\u2009=\u20090.031. Patients with mutation also had a greater chance of recovery from hypertension after operation (p\u2009=\u20090.005). A high incidence of somatic mutations in APA was identified in the Taiwanese population. Mutation-carriers had lower CRP levels and a higher rate of cure of hypertension after adrenalectomy. This raises the possibility of using mutation screening as a tool in predicting long-term outcome after adrenalectomy.<\/jats:p>","DOI":"10.1038\/srep11396","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T14:05:30Z","timestamp":1434117930000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population"],"prefix":"10.1038","volume":"5","author":[{"given":"Vin-Cent","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-How","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Yung","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Chou","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che-Hsiung","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo-Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian-Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Hung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuei-Liong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong-Shinn","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan-Dun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,12]]},"reference":[{"key":"BFsrep11396_CR1","first-page":"598","volume":"100","author":"KD Wu","year":"2001","unstructured":"Wu, K. 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