{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:34:20Z","timestamp":1784183660869,"version":"3.55.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although various imaging studies have focused on detecting the cerebral function underlying psychogenic non-epileptic seizures (PNES), the nature of PNES remains poorly understood. In this study, we combined the resting state fMRI with fractional amplitude of low-frequency fluctuations (fALFF) and functional connectivity based on the seed voxel linear correlation approach to examine the alterations of regional and inter-regional network cerebral functions in PNES. A total of 20 healthy controls and 18 patients were enrolled. The PNES patients showed significantly increased fALFF mainly in the dorsolateral prefrontal cortex (DLPFC), parietal cortices and motor areas, as well as decreased fALFF in the triangular inferior frontal gyrus. Thus, our results add to literature suggesting abnormalities of neural synchrony in PNES. Moreover, PNES exhibited widespread inter-regional neural network deficits, including increased (DLPFC, sensorimotor and limbic system) and decreased (ventrolateral prefrontal cortex) connectivity, indicating that changes in the regional cerebral function are related to remote inter-regional network deficits. Correlation analysis results revealed that the connectivity between supplementary motor area and anterior cingulate cortex correlated with the PNES frequency, further suggesting the skewed integration of synchronous activity could predispose to the occurrence of PNES. Our findings provided novel evidence to investigate the pathophysiological mechanisms of PNES.<\/jats:p>","DOI":"10.1038\/srep11635","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T11:00:38Z","timestamp":1435230038000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Altered regional activity and inter-regional functional connectivity in psychogenic non-epileptic seizures"],"prefix":"10.1038","volume":"5","author":[{"given":"Rong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"key":"BFsrep11635_CR1","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.seizure.2009.06.006","volume":"18","author":"NM Bodde","year":"2009","unstructured":"Bodde, N. M. et al. Psychogenic non-epileptic seizures\u2014definition, etiology, treatment and prognostic issues: a critical review. Seizure. 18, 543\u2013553 (2009).","journal-title":"Seizure."},{"key":"BFsrep11635_CR2","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.yebeh.2004.11.005","volume":"6","author":"ME Witgert","year":"2005","unstructured":"Witgert, M. E., Wheless, J. W. & Breier, J. I. Frequency of panic symptoms in psychogenic nonepileptic seizures. Epilepsy Behav. 6, 174\u2013178 (2005).","journal-title":"Epilepsy Behav."},{"key":"BFsrep11635_CR3","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.seizure.2006.04.003","volume":"15","author":"L D\u2019Alessio","year":"2006","unstructured":"D\u2019Alessio, L. et al. Psychiatric disorders in patients with psychogenic non-epileptic seizures, with and without comorbid epilepsy. Seizure. 15, 333\u2013339 (2006).","journal-title":"Seizure."},{"key":"BFsrep11635_CR4","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1136\/jnnp.2010.224873","volume":"82","author":"MG Knyazeva","year":"2011","unstructured":"Knyazeva, M. G., Jalili, M., Frackowiak, R. S. & Rossetti, A. O. Psychogenic seizures and frontal disconnection: EEG synchronisation study. J Neurol Neurosurg Psychiatry. 82, 505\u2013511 (2011).","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"BFsrep11635_CR5","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1136\/jnnp-2011-300776","volume":"83","author":"SJ van der Kruijs","year":"2012","unstructured":"van der Kruijs, S. J. et al. Functional connectivity of dissociation in patients with psychogenic non-epileptic seizures. J Neurol Neurosurg Psychiatry. 83, 239\u2013247 (2012).","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"BFsrep11635_CR6","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1177\/0300060513496170","volume":"41","author":"Q Xue","year":"2013","unstructured":"Xue, Q. et al. Altered brain connectivity in patients with psychogenic non-epileptic seizures: a scalp electroencephalography study. J Int Med Res. 41, 1682\u20131690 (2013).","journal-title":"J Int Med Res."},{"key":"BFsrep11635_CR7","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3389\/fnhum.2012.00335","volume":"6","author":"E Barzegaran","year":"2012","unstructured":"Barzegaran, E. et al. Properties of functional brain networks correlate with frequency of psychogenic non-epileptic seizures. Front Hum Neurosci. 6, 335 (2012).","journal-title":"Front Hum Neurosci."},{"key":"BFsrep11635_CR8","doi-asserted-by":"crossref","unstructured":"Zhang, Z. et al. Pathological uncoupling between amplitude and connectivity of brain fluctuations in epilepsy. Hum Brain Mapp. (2015).","DOI":"10.1002\/hbm.22805"},{"key":"BFsrep11635_CR9","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.pnpbp.2012.07.004","volume":"39","author":"F Liu","year":"2012","unstructured":"Liu, F. et al. Abnormal regional spontaneous neural activity in first-episode, treatment-naive patients with late-life depression: a resting-state fMRI study. Prog Neuropsychopharmacol Biol Psychiatry. 39, 326\u2013331 (2012).","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"BFsrep11635_CR10","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1002\/jmri.20577","volume":"23","author":"J Gotman","year":"2006","unstructured":"Gotman, J., Kobayashi, E., Bagshaw, A. P., Benar, C. G. & Dubeau, F. Combining EEG and fMRI: a multimodal tool for epilepsy research. J Magn Reson Imaging. 23, 906\u2013920 (2006).","journal-title":"J Magn Reson Imaging."},{"key":"BFsrep11635_CR11","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.jad.2011.06.048","volume":"135","author":"WB Guo","year":"2011","unstructured":"Guo, W. B. et al. Abnormal neural activities in first-episode, treatment-naive, short-illness-duration and treatment-response patients with major depressive disorder: a resting-state fMRI study. J Affect Disord. 135, 326\u2013331 (2011).","journal-title":"J Affect Disord."},{"key":"BFsrep11635_CR12","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/mrm.1910340409","volume":"34","author":"B Biswal","year":"1995","unstructured":"Biswal, B., Yetkin, F. Z., Haughton, V. M. & Hyde, J. S. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med. 34, 537\u2013541 (1995).","journal-title":"Magn Reson Med."},{"key":"BFsrep11635_CR13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.braindev.2006.10.001","volume":"29","author":"YF Zang","year":"2007","unstructured":"Zang, Y. F. et al. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Dev. 29, 83\u201391 (2007).","journal-title":"Brain Dev."},{"key":"BFsrep11635_CR14","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jneumeth.2008.04.012","volume":"172","author":"QH Zou","year":"2008","unstructured":"Zou, Q. H. et al. An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: fractional ALFF. J Neurosci Methods. 172, 137\u2013141 (2008).","journal-title":"J Neurosci Methods."},{"key":"BFsrep11635_CR15","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/j.neuroimage.2009.09.037","volume":"49","author":"XN Zuo","year":"2010","unstructured":"Zuo, X. N. et al. The oscillating brain: complex and reliable. Neuroimage. 49, 1432\u20131445 (2010).","journal-title":"Neuroimage."},{"key":"BFsrep11635_CR16","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.jad.2012.10.001","volume":"146","author":"F Liu","year":"2013","unstructured":"Liu, F. et al. Abnormal amplitude low-frequency oscillations in medication-naive, first-episode patients with major depressive disorder: a resting-state fMRI study. J Affect Disord. 146, 401\u2013406 (2013).","journal-title":"J Affect Disord."},{"key":"BFsrep11635_CR17","doi-asserted-by":"publisher","first-page":"e63850","DOI":"10.1371\/journal.pone.0063850","volume":"8","author":"JR Ding","year":"2013","unstructured":"Ding, J. R. et al. Altered functional and structural connectivity networks in psychogenic non-epileptic seizures. PLoS One. 8, e63850 (2013).","journal-title":"PLoS One."},{"key":"BFsrep11635_CR18","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/nature07664","volume":"457","author":"YB Sirotin","year":"2009","unstructured":"Sirotin, Y. B. & Das, A. Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity. Nature. 457, 475\u2013479 (2009).","journal-title":"Nature."},{"key":"BFsrep11635_CR19","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/hbm.22164","volume":"35","author":"A Abou Elseoud","year":"2014","unstructured":"Abou Elseoud, A. et al. Altered resting-state activity in seasonal affective disorder. Hum Brain Mapp. 35, 161\u2013172 (2014).","journal-title":"Hum Brain Mapp."},{"key":"BFsrep11635_CR20","doi-asserted-by":"publisher","first-page":"e30570","DOI":"10.1371\/journal.pone.0030570","volume":"7","author":"Y Xuan","year":"2012","unstructured":"Xuan, Y. et al. Resting-state brain activity in adult males who stutter. PLoS One. 7, e30570 (2012).","journal-title":"PLoS One."},{"key":"BFsrep11635_CR21","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s10548-014-0386-2","volume":"28","author":"F Liu","year":"2015","unstructured":"Liu, F. et al. Characterization of post-traumatic stress disorder using resting-state fMRI with a multi-level parametric classification approach. Brain Topogr. 28, 221\u2013237 (2015).","journal-title":"Brain Topogr."},{"key":"BFsrep11635_CR22","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1001\/archgenpsychiatry.2010.84","volume":"67","author":"S Lui","year":"2010","unstructured":"Lui, S. et al. Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by \u201cresting state\u201d functional magnetic resonance imaging. Arch Gen Psychiatry. 67, 783\u2013792 (2010).","journal-title":"Arch Gen Psychiatry."},{"key":"BFsrep11635_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.seizure.2010.10.032","volume":"20","author":"G Baslet","year":"2011","unstructured":"Baslet, G. Psychogenic non-epileptic seizures: a model of their pathogenic mechanism. Seizure. 20, 1\u201313 (2011).","journal-title":"Seizure."},{"key":"BFsrep11635_CR24","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.yebeh.2013.09.035","volume":"30","author":"NA Roberts","year":"2014","unstructured":"Roberts, N. A. & Reuber, M. Alterations of consciousness in psychogenic nonepileptic seizures: emotion, emotion regulation and dissociation. Epilepsy Behav. 30, 43\u201349 (2014).","journal-title":"Epilepsy Behav."},{"key":"BFsrep11635_CR25","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/jcpp.12307","volume":"56","author":"HJ Li","year":"2015","unstructured":"Li, H. J., Xu, Y., Zhang, K. R., Hoptman, M. J. & Zuo, X. N. Homotopic connectivity in drug-naive, first-episode, early-onset schizophrenia. J Child Psychol Psychiatry. 56, 432\u2013443 (2015).","journal-title":"J Child Psychol Psychiatry."},{"key":"BFsrep11635_CR26","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1093\/brain\/awq054","volume":"133","author":"V Voon","year":"2010","unstructured":"Voon, V. et al. Emotional stimuli and motor conversion disorder. Brain. 133, 1526\u20131536 (2010).","journal-title":"Brain."},{"key":"BFsrep11635_CR27","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1016\/j.neuroimage.2008.04.171","volume":"41","author":"M Landgrebe","year":"2008","unstructured":"Landgrebe, M. et al. Neuronal correlates of symptom formation in functional somatic syndromes: a fMRI study. Neuroimage. 41, 1336\u20131344 (2008).","journal-title":"Neuroimage."},{"key":"BFsrep11635_CR28","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.neuroimage.2007.02.041","volume":"37","author":"ME Raichle","year":"2007","unstructured":"Raichle, M. E. & Snyder, A. Z. A default mode of brain function: a brief history of an evolving idea. Neuroimage. 37, 1083-1090; discussion 1097\u20131089 (2007).","journal-title":"Neuroimage."},{"key":"BFsrep11635_CR29","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jpsychires.2014.03.010","volume":"54","author":"SJ van der Kruijs","year":"2014","unstructured":"van der Kruijs, S. J. et al. Resting-state networks and dissociation in psychogenic non-epileptic seizures. J Psychiatr Res. 54, 126\u2013133 (2014).","journal-title":"J Psychiatr Res."},{"key":"BFsrep11635_CR30","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/brain\/awl004","volume":"129","author":"AE Cavanna","year":"2006","unstructured":"Cavanna, A. E. & Trimble, M. R. The precuneus: a review of its functional anatomy and behavioural correlates. Brain. 129, 564\u2013583 (2006).","journal-title":"Brain."},{"key":"BFsrep11635_CR31","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.neuroimage.2009.05.023","volume":"47","author":"Y Cojan","year":"2009","unstructured":"Cojan, Y., Waber, L., Carruzzo, A. & Vuilleumier, P. Motor inhibition in hysterical conversion paralysis. Neuroimage. 47, 1026\u20131037 (2009).","journal-title":"Neuroimage."},{"key":"BFsrep11635_CR32","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/j.1528-1167.2011.03347.x","volume":"53","author":"A Labate","year":"2012","unstructured":"Labate, A. et al. Neuroanatomic correlates of psychogenic nonepileptic seizures: a cortical thickness and VBM study. Epilepsia. 53, 377\u2013385 (2012).","journal-title":"Epilepsia."},{"key":"BFsrep11635_CR33","doi-asserted-by":"publisher","first-page":"2883","DOI":"10.1016\/j.neuropsychologia.2007.06.015","volume":"45","author":"D Badre","year":"2007","unstructured":"Badre, D. & Wagner, A. D. Left ventrolateral prefrontal cortex and the cognitive control of memory. Neuropsychologia. 45, 2883\u20132901 (2007).","journal-title":"Neuropsychologia."},{"key":"BFsrep11635_CR34","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.yebeh.2010.08.026","volume":"19","author":"P Bakvis","year":"2010","unstructured":"Bakvis, P., Spinhoven, P., Putman, P., Zitman, F. G. & Roelofs, K. The effect of stress induction on working memory in patients with psychogenic nonepileptic seizures. Epilepsy Behav. 19, 448\u2013454 (2010).","journal-title":"Epilepsy Behav."},{"key":"BFsrep11635_CR35","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1016\/j.eplepsyres.2014.05.006","volume":"108","author":"J Ding","year":"2014","unstructured":"Ding, J. et al. Abnormal functional connectivity density in psychogenic non-epileptic seizures. Epilepsy Res. 108, 1184\u20131194 (2014).","journal-title":"Epilepsy Res."},{"key":"BFsrep11635_CR36","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1016\/j.neuropsychologia.2010.02.029","volume":"48","author":"FP de Lange","year":"2010","unstructured":"de Lange, F. P., Toni, I. & Roelofs, K. Altered connectivity between prefrontal and sensorimotor cortex in conversion paralysis. Neuropsychologia. 48, 1782\u20131788 (2010).","journal-title":"Neuropsychologia."},{"key":"BFsrep11635_CR37","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.neunet.2005.03.005","volume":"18","author":"JG Taylor","year":"2005","unstructured":"Taylor, J. G. & Fragopanagos, N. F. The interaction of attention and emotion. Neural Netw. 18, 353\u2013369 (2005).","journal-title":"Neural Netw."},{"key":"BFsrep11635_CR38","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1016\/j.neuroimage.2005.08.033","volume":"29","author":"M Burgmer","year":"2006","unstructured":"Burgmer, M. et al. Abnormal brain activation during movement observation in patients with conversion paralysis. Neuroimage. 29, 1336\u20131343 (2006).","journal-title":"Neuroimage."},{"key":"BFsrep11635_CR39","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1176\/jnp.23.2.jnp121","volume":"23","author":"FL Stevens","year":"2011","unstructured":"Stevens, F. L., Hurley, R. A. & Taber, K. H. Anterior cingulate cortex: unique role in cognition and emotion. J Neuropsychiatry Clin Neurosci. 23, 121\u2013125 (2011).","journal-title":"J Neuropsychiatry Clin Neurosci."},{"key":"BFsrep11635_CR40","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/nrn2994","volume":"12","author":"AJ Shackman","year":"2011","unstructured":"Shackman, A. J. et al. The integration of negative affect, pain and cognitive control in the cingulate cortex. Nat Rev Neurosci. 12, 154\u2013167 (2011).","journal-title":"Nat Rev Neurosci."},{"key":"BFsrep11635_CR41","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1080\/10543400701376480","volume":"17","author":"HX Barnhart","year":"2007","unstructured":"Barnhart, H. X., Haber, M. J. & Lin, L. I. An overview on assessing agreement with continuous measurements. J Biopharm Stat. 17, 529\u2013569 (2007).","journal-title":"J Biopharm Stat."},{"key":"BFsrep11635_CR42","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neubiorev.2014.05.009","volume":"45","author":"XN Zuo","year":"2014","unstructured":"Zuo, X. N. & Xing, X. X. Test-retest reliabilities of resting-state FMRI measurements in human brain functional connectomics: a systems neuroscience perspective. Neurosci Biobehav Rev. 45, 100\u2013118 (2014).","journal-title":"Neurosci Biobehav Rev."},{"key":"BFsrep11635_CR43","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1016\/j.neuroimage.2009.10.080","volume":"49","author":"XN Zuo","year":"2010","unstructured":"Zuo, X. N. et al. Reliable intrinsic connectivity networks: test-retest evaluation using ICA and dual regression approach. Neuroimage. 49, 2163\u20132177 (2010).","journal-title":"Neuroimage."},{"key":"BFsrep11635_CR44","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1212\/01.WNL.0000143273.18099.50","volume":"63","author":"SR Benbadis","year":"2004","unstructured":"Benbadis, S. R., Siegrist, K., Tatum, W. O., Heriaud, L. & Anthony, K. Short-term outpatient EEG video with induction in the diagnosis of psychogenic seizures. Neurology. 63, 1728\u20131730 (2004).","journal-title":"Neurology."},{"key":"BFsrep11635_CR45","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nrneurol.2011.24","volume":"7","author":"O Devinsky","year":"2011","unstructured":"Devinsky, O., Gazzola, D. & LaFrance, W. C., Jr. Differentiating between nonepileptic and epileptic seizures. Nat Rev Neurol. 7, 210\u2013220 (2011).","journal-title":"Nat Rev Neurol."},{"key":"BFsrep11635_CR46","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.neuroimage.2011.12.063","volume":"60","author":"TD Satterthwaite","year":"2012","unstructured":"Satterthwaite, T. D. et al. Impact of in-scanner head motion on multiple measures of functional connectivity: relevance for studies of neurodevelopment in youth. Neuroimage. 60, 623\u2013632 (2012).","journal-title":"Neuroimage."},{"key":"BFsrep11635_CR47","doi-asserted-by":"publisher","first-page":"3270","DOI":"10.1152\/jn.90777.2008","volume":"101","author":"MD Fox","year":"2009","unstructured":"Fox, M. D., Zhang, D., Snyder, A. Z. & Raichle, M. E. The global signal and observed anticorrelated resting state brain networks. J Neurophysiol. 101, 3270\u20133283 (2009).","journal-title":"J Neurophysiol."},{"key":"BFsrep11635_CR48","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.pnpbp.2013.01.010","volume":"44","author":"W Guo","year":"2013","unstructured":"Guo, W. et al. Abnormal resting-state cerebellar-cerebral functional connectivity in treatment-resistant depression and treatment sensitive depression. Prog Neuropsychopharmacol Biol Psychiatry. 44, 51\u201357 (2013).","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry."},{"key":"BFsrep11635_CR49","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/nimg.2001.0978","volume":"15","author":"N Tzourio-Mazoyer","year":"2002","unstructured":"Tzourio-Mazoyer, N. et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage. 15, 273\u2013289 (2002).","journal-title":"Neuroimage."},{"key":"BFsrep11635_CR50","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1016\/j.neuroimage.2011.10.018","volume":"59","author":"JD Power","year":"2012","unstructured":"Power, J. D., Barnes, K. A., Snyder, A. Z., Schlaggar, B. L. & Petersen, S. E. Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage. 59, 2142\u20132154 (2012).","journal-title":"Neuroimage."},{"key":"BFsrep11635_CR51","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.neuroimage.2011.07.044","volume":"59","author":"KR Van Dijk","year":"2012","unstructured":"Van Dijk, K. R., Sabuncu, M. R. & Buckner, R. L. The influence of head motion on intrinsic functional connectivity MRI. Neuroimage. 59, 431\u2013438 (2012).","journal-title":"Neuroimage."},{"key":"BFsrep11635_CR52","unstructured":"Liu, F. et al. Disrupted cortical hubs in functional brain networks in social anxiety disorder. Clin Neurophysiol. (2014)."},{"key":"BFsrep11635_CR53","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1002\/hbm.20625","volume":"30","author":"G Bettus","year":"2009","unstructured":"Bettus, G. et al. Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms. Hum Brain Mapp. 30, 1580\u20131591 (2009).","journal-title":"Hum Brain Mapp."},{"key":"BFsrep11635_CR54","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.neuroimage.2008.09.036","volume":"44","author":"K Murphy","year":"2009","unstructured":"Murphy, K., Birn, R. M., Handwerker, D. A., Jones, T. B. & Bandettini, P. A. The impact of global signal regression on resting state correlations: are anti-correlated networks introduced? Neuroimage. 44, 893\u2013905 (2009).","journal-title":"Neuroimage."},{"key":"BFsrep11635_CR55","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1016\/j.neuroimage.2009.05.005","volume":"47","author":"A Weissenbacher","year":"2009","unstructured":"Weissenbacher, A. et al. Correlations and anticorrelations in resting-state functional connectivity MRI: a quantitative comparison of preprocessing strategies. Neuroimage. 47, 1408\u20131416 (2009).","journal-title":"Neuroimage."},{"key":"BFsrep11635_CR56","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/ana.20733","volume":"59","author":"AB Waites","year":"2006","unstructured":"Waites, A. B., Briellmann, R. S., Saling, M. M., Abbott, D. F. & Jackson, G. D. Functional connectivity networks are disrupted in left temporal lobe epilepsy. Ann Neurol. 59, 335\u2013343 (2006).","journal-title":"Ann Neurol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep11635","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep11635.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep11635.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T14:01:37Z","timestamp":1672927297000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep11635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,25]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12,18]]}},"alternative-id":["BFsrep11635"],"URL":"https:\/\/doi.org\/10.1038\/srep11635","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,25]]},"assertion":[{"value":"11 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"11635"}}