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The relationship between the <jats:italic>MMP3<\/jats:italic> -1171 5A\/6A polymorphism (rs35068180) and periodontitis has been widely studied. However, existing studies have yielded contradictory results. We therefore conducted a meta-analysis to comprehensively investigate these inconclusive findings. Several electronic databases were searched for eligible articles. Seven case-control studies from 6 articles were searched without any language restrictions. Pooled estimates indicated that <jats:italic>MMP3<\/jats:italic> -1171 5A\/6A polymorphism is associated with a decreased risk of periodontitis (allelic genetic model: OR\u2009=\u20090.70, 95% CI: 0.62\u20130.80, <jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub>\u2009=\u20090.315; heterozygous model: OR\u2009=\u20090.50, 95% CI: 0.39\u20130.65, <jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub>\u2009=\u20090.221; homozygous model: OR\u2009=\u20090.42, 95% CI: 0.25\u20130.69, <jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub>\u2009=\u20090.265; dominant model: OR\u2009=\u20090.49, 95% CI: 0.38\u20130.62, <jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub>\u2009=\u20090.238, respectively). Similar results were also found in chronic periodontitis (CP), Asian, Asian&amp;CP and non-smokers subgroups. Moreover, <jats:italic>MMP3<\/jats:italic> rs35068180 polymorphism might be associated with a lower risk of aggressive periodontitis (AgP) in Asians (allelic genetic model: OR\u2009=\u20090.66, 95% CI: 0.48\u20130.91, <jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub>\u2009=\u20090.945) and CP in Caucasians and Brazilians. In conclusion, this meta-analysis demonstrates that <jats:italic>MMP3<\/jats:italic> -1171 5A\/6A polymorphism may be associated with decreased risk of both CP and AgP in Asians. Large independent studies to replicate these results are necessary to validate these associations in other populations.<\/jats:p>","DOI":"10.1038\/srep11667","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T10:56:38Z","timestamp":1435661798000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Matrix Metalloproteinase-3 -1171 5A\/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis"],"prefix":"10.1038","volume":"5","author":[{"given":"Cheng","family":"Ding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng-tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-jun","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,6,30]]},"reference":[{"key":"BFsrep11667_CR1","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","volume":"366","author":"BL Pihlstrom","year":"2005","unstructured":"Pihlstrom, B. 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