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We aimed to evaluate the effect of LCBDE on the clinical outcome of those patients within (early) or beyond (delayed) 72\u2009hours of emergent admission. Surgery-related complications, length of hospital stay (LOS) and total cost, as well as demographic and clinical parameters were compared between the two groups. Finally, 3 and 5 patients in early and delayed LCBDE group, respectively, had retained stones, which were removed by choledochoscopy before T-tube was removed. Each group had 3 patients who developed biliary leak, which was conservatively cured by the drainage. Shorter LOS and less total cost were observed in early group compared to the late one (13.34\u2009\u00b1\u20094.48 vs. 18.32\u2009\u00b1\u20099.13, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05; 17712\u2009\u00b1\u20095446.63 vs. 21776\u2009\u00b1\u20097230.41 \u00a5RMB, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Improvement of cholangitis was achieved in all patients with LCBDE. None of the patients developed stricture of the CBD after LCBDE. To conclude, both early and delayed LCBDE are safe and effective for the treatment of CBD stone-related nonsevere acute cholangitis during emergent admissions. Early LCBDE may be superior to delayed procedure due to the shorter LOS and less cost.<\/jats:p>","DOI":"10.1038\/srep11748","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T12:00:34Z","timestamp":1435665634000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Early versus delayed laparoscopic common bile duct exploration for common bile duct stone-related nonsevere acute cholangitis"],"prefix":"10.1038","volume":"5","author":[{"given":"Bin","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buhe","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,30]]},"reference":[{"key":"BFsrep11748_CR1","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1136\/gut.2007.121657","volume":"57","author":"EJ Williams","year":"2008","unstructured":"Williams, E. 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