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It is required for unilocular lipid droplet formation and optimal energy storage. The mechanism between this gene and livestock growth traits, however, has yet to be reported. In this study, we found ten novel single nucleotide polymorphisms (SNPs) in the 5\u2019 transcriptional region of <jats:italic>CIDEC<\/jats:italic> in Nanyang (NY) cattle, which are located in the recognition sequences (potential <jats:italic>cis<\/jats:italic>-acting elements) of 22 transcription factors and the nine haplotypes represent nine different combinations of polymorphic potential <jats:italic>cis<\/jats:italic>-acting elements. The results indicated that individuals with the H8-H8 diplotype had heavier body weights and faster growth rates (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) at 18th months than those with H1-H8. We evaluated the transcriptional activities of different haplotypes <jats:italic>in vitro<\/jats:italic>, the results were consistent with the association analysis. The H8 haplotype had 1.88-fold (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) higher transcriptional activity than the H1 haplotype. We speculate that the haplotypes of the potential <jats:italic>cis<\/jats:italic>-acting elements may affect the transcriptional activity of <jats:italic>CIDEC<\/jats:italic>, thus affecting the growth traits of cattle. This information may be used in molecular marker-assisted selection of cattle breeding in the future.<\/jats:p>","DOI":"10.1038\/srep12075","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T10:01:41Z","timestamp":1437386501000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Haplotypes in the promoter region of the CIDEC gene associated with growth traits in Nanyang cattle"],"prefix":"10.1038","volume":"5","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu-shuai","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-zhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-xun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-zhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuan-jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-yong","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chu-zhao","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong-jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,7,20]]},"reference":[{"key":"BFsrep12075_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/MOL.0b013e32832956c7","volume":"20","author":"M Traini","year":"2009","unstructured":"Traini, M. & Jessup, W. 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