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Here we show that E-cadherin overexpression in Raw 264.7 macrophages inhibits their inflammatory response to LPS stimulation, as demonstrated by a reduced secretion of inflammatory mediators like interleukin (IL)-6,\n                    <jats:italic>tumor necrosis factor<\/jats:italic>\n                    (TNF) and nitric oxide (NO). To study the function of E-cadherin in M\n                    <jats:sub>(IL-4\/IL-13)<\/jats:sub>\n                    macrophages\n                    <jats:italic>in vivo<\/jats:italic>\n                    , we generated macrophage-specific E-cadherin-deficient C57BL\/6 mice. Using this new tool, we analyzed immunological parameters during two typical AAM-associated Th2-driven diseases and assessed Th2-associated granuloma formation. Although E-cadherin is strongly induced in AAMs during\n                    <jats:italic>Taenia crassiceps<\/jats:italic>\n                    helminth infections and allergic airway inflammation, its deletion in macrophages does not affect the course of both Th2 cytokine-driven diseases. Moreover, macrophage E-cadherin expression is largely redundant for granuloma formation around\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    ova. Overall, we conclude that E-cadherin is a valuable AAM marker which suppresses the inflammatory response when overexpressed. Yet E-cadherin deletion in macrophages does not affect M\n                    <jats:sub>(LPS+IFN\u03b3)<\/jats:sub>\n                    and M\n                    <jats:sub>(IL-4)<\/jats:sub>\n                    polarization\n                    <jats:italic>in vitro<\/jats:italic>\n                    , nor\n                    <jats:italic>in vivo<\/jats:italic>\n                    macrophage function, at least in the conditions tested.\n                  <\/jats:p>","DOI":"10.1038\/srep12599","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T05:14:32Z","timestamp":1438319672000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo"],"prefix":"10.1038","volume":"5","author":[{"given":"Jan","family":"Van den Bossche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damya","family":"Laoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Naessens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermelijn H.","family":"Smits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis H.","family":"Hokke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Stijlemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Grooten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"De Baetselier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo A.","family":"Van Ginderachter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"BFsrep12599_CR1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","volume":"41","author":"PJ Murray","year":"2014","unstructured":"Murray, P. 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