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We analyzed the correlation between the expression of amino acid transporters and PPARs and investigated whether PPARs control the expression of amino acid transporters in placentas. It was found that protein expression of PPAR\u03b3 and L-type amino acid transporter 1(LAT1) and 2 (LAT2) was decreased in small-for-gestational-age (SGA) placentas. LAT1, LAT2 and taurine transporter (TAUT) expression correlated to PPAR\u03b3 level and birth weight. In cultured placental cells, PPAR\u03b3 agonist stimulated LAT1 and LAT2 and TAUT, which was reversed by PPAR\u03b3 siRNA. PPAR\u03b3 up-regulation of LAT1 and TAUT was through specificity protein 1 (Sp-1) while stimulation of LAT2 expression was via induction of gene transcription. Our data suggest that PPAR\u03b3, SP-1, LAT1 and LAT2 in placentas are involved in control of fetal growth. PPAR\u03b3 signaling pathway may be the therapeutic target for intrauterine growth restriction.<\/jats:p>","DOI":"10.1038\/srep12650","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T09:15:47Z","timestamp":1438334147000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["PPAR\u03b3 stimulates expression of L-type amino acid and taurine transporters in human placentas: the evidence of PPAR\u03b3 regulating fetal growth"],"prefix":"10.1038","volume":"5","author":[{"given":"Zhaoguang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"BFsrep12650_CR1","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/0002-9378(95)90628-2","volume":"173","author":"AA Fanaroff","year":"1995","unstructured":"Fanaroff, A. 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