{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:35:18Z","timestamp":1761896118856},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T00:00:00Z","timestamp":1438819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T00:00:00Z","timestamp":1438819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Apoptosis of the splenic lymphocytes is often induced during the acute phase of <jats:italic>Listeria<\/jats:italic> infection in mice. However, the underlying mechanism remains incompletely understood. Here, we found that herpes virus entry mediator (HVEM) plays an important role for <jats:italic>Listeria<\/jats:italic> infection induced lymphocyte apoptosis. Mechanistically, HVEM is not directly involved in listeriolysin O (LLO) induced lymphocyte apoptosis or interferon beta induced T cell activation per se. Interestingly, HVEM is partially required for <jats:italic>Listeria<\/jats:italic> induced interferon (IFN)-I production in the spleen, particularly in macrophages. Consequently, the bystander activation of lymphocytes is significantly lower in HVEM deficient mice than that in wild-type (WT) mice upon <jats:italic>Listeria<\/jats:italic> infection. Thus, our results have revealed a novel role of HVEM on the regulation of IFN-I and immunopathology during <jats:italic>Listeria<\/jats:italic> infection.<\/jats:p>","DOI":"10.1038\/srep12954","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T09:34:28Z","timestamp":1438853668000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Herpes virus entry mediator licenses Listeria infection induced immunopathology through control of type I interferon"],"prefix":"10.1038","volume":"5","author":[{"given":"Mengjie","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuejiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,8,6]]},"reference":[{"key":"BFsrep12954_CR1","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1086\/314008","volume":"31","author":"WF Schlech 3rd","year":"2000","unstructured":"Schlech, W. 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