{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:37:13Z","timestamp":1782603433764,"version":"3.54.5"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extracorporeal membrane oxygenation (ECMO) has been repeatedly used to rescue patients with cardiopulmonary arrest. However, its clinical utility in endocrine emergencies remains unclear. Herein, we describe a case series of 12 patients presenting with refractory shock secondary to endocrine emergencies who were rescued by ECMO support. Patients were identified between 2005 and 2012 from our ECMO registry. The diagnostic distribution was as follows: pheochromocytoma crisis (n\u2009=\u20094), thyroid storm (n\u2009=\u20095) and diabetic ketoacidosis (n\u2009=\u20093). The initial presentation of pheochromocytoma crisis was indistinguishable from acute myocardial infarction (AMI) and frequently accompanied by paroxysmal hypertension and limb ischemia. Thyroid storm was characterized by hyperbilirubinemia and severe gastrointestinal bleeding, whereas neurological symptoms were common in diabetic ketoacidosis. The clinical outcomes of patients with endocrine emergencies were compared with those of 80 cases with AMI who received ECMO because of cardiogenic shock. The cardiac function and the general conditions showed a significantly faster recovery in patients with endocrine emergencies than in those with AMI. We conclude that ECMO support can be clinically useful in endocrine emergencies. The screening of endocrine diseases should be considered during the resuscitation of patients with refractory circulatory shock.<\/jats:p>","DOI":"10.1038\/srep13361","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T09:19:01Z","timestamp":1440407941000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Highlighting Indication of extracorporeal membrane oxygenation in endocrine emergencies"],"prefix":"10.1038","volume":"5","author":[{"given":"Anne","family":"Chao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsien","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Chun","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Kwoun","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsi-Yu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Hsin","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Chien","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Hui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jung","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hsien","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih-Sharng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,24]]},"reference":[{"key":"BFsrep13361_CR1","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/S0140-6736(09)61069-2","volume":"374","author":"GJ Peek","year":"2009","unstructured":"Peek, G. J. et al. Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet 374, 1351\u20131363 (2009) .","journal-title":"Lancet"},{"key":"BFsrep13361_CR2","doi-asserted-by":"crossref","unstructured":"Baud, F. J., Megarbane, B., Deye, N. & Leprince, P. Clinical review: Aggressive management and extracorporeal support for drug-induced cardiotoxicity. Crit Care. 10.1186\/cc5700 (2007).","DOI":"10.1186\/cc5700"},{"key":"BFsrep13361_CR3","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1016\/S0003-4975(99)01174-1","volume":"68","author":"YS Chen","year":"1999","unstructured":"Chen, Y. S. et al. Rescue for acute myocarditis with shock by extracorporeal membrane oxygenation. Ann Thorac Surg 68, 2220\u20132224 (1999).","journal-title":"Ann Thorac Surg"},{"key":"BFsrep13361_CR4","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1046\/j.1525-1594.2001.025008622.x","volume":"25","author":"NK Chou","year":"2001","unstructured":"Chou, N. K. et al. Application of extracorporeal membrane oxygenation in adult burn patients. Artif Organs 25, 622\u2013626 (2001).","journal-title":"Artif Organs"},{"key":"BFsrep13361_CR5","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/S0140-6736(08)60958-7","volume":"372","author":"YS Chen","year":"2008","unstructured":"Chen, Y. S. et al. Cardiopulmonary resuscitation with assisted extracorporeal life-support versus conventional cardiopulmonary resuscitation in adults with in-hospital cardiac arrest: an observational study and propensity analysis. Lancet 372, 554\u2013561 (2008).","journal-title":"Lancet"},{"key":"BFsrep13361_CR6","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/S0003-4975(01)03330-6","volume":"73","author":"WJ Ko","year":"2003","unstructured":"Ko, W. J. et al. Extracorporeal membrane support for adult postcardiotomy cardiogenic shock. Ann Thorac Surg 73, 538\u2013545 (2003).","journal-title":"Ann Thorac Surg"},{"key":"BFsrep13361_CR7","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.recesp.2012.12.014","volume":"66","author":"A Ariza-Sol\u00e9","year":"2013","unstructured":"Ariza-Sol\u00e9, A. et al. Ventricular support With Extracorporeal Membrane Oxygenation: A New Rescue Alternative for Refractory Cardiogenic Shock. Rev Esp Cardiol 66, 501\u2013503 (2013).","journal-title":"Rev Esp Cardiol"},{"key":"BFsrep13361_CR8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0735-1097(02)02716-X","volume":"41","author":"YS Chen","year":"2003","unstructured":"Chen, Y. S. et al. Analysis and results of prolonged resuscitation in cardiac arrest patients rescued by extracorporeal membrane oxygenation. J Am Coll Cardiol 41, 197\u2013203 (2003).","journal-title":"J Am Coll Cardiol"},{"key":"BFsrep13361_CR9","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1365-2044.2007.05251.x","volume":"63","author":"A Chao","year":"2008","unstructured":"Chao, A., Yeh, Y. C., Yen, T. S. & Chen, Y. S. Phaeochromocytoma crisis \u2013 a rare indication for extracorporeal membrane oxygenation. Anaesthesia 63, 86\u201388 (2008).","journal-title":"Anaesthesia"},{"key":"BFsrep13361_CR10","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3346\/jkms.2008.23.2.350","volume":"23","author":"IW Suh","year":"2008","unstructured":"Suh, I. W. et al. Catastrophic catecholamine-induced cardiomyopathy mimicking acute myocardial infarction, rescued by extracorporeal membrane oxygenation (ECMO) in pheochromocytoma. J Korean Med Sci 23, 350\u2013354 (2008).","journal-title":"J Korean Med Sci"},{"key":"BFsrep13361_CR11","first-page":"154","volume":"16","author":"T Ezri","year":"2008","unstructured":"Ezri, T., Golan, A., Sasson, L. & Rozenman, Y. Pheochromocytoma induced fulminant cardiogenic shock following laparoscopic salpingectomy, successfully managed with extracorporeal membrane oxygenation. Jurnalul Rom\u00e2n de Anestezie Terapie Intensiv\u00e3 16, 154\u2013158 (2008).","journal-title":"Jurnalul Rom\u00e2n de Anestezie Terapie Intensiv\u00e3"},{"key":"BFsrep13361_CR12","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1510\/icvts.2011.266023","volume":"13","author":"S Ritter","year":"2011","unstructured":"Ritter, S., Guertler, T., Meier, C. A. & Genoni, M. Cardiogenic shock due to pheochromocytoma rescued by extracorporeal membrane oxygenation. Interact Cardiovasc Thorac Surg 13, 112\u2013113 (2011).","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"BFsrep13361_CR13","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/S0140-6736(12)60910-6","volume":"380","author":"A Noorani","year":"2012","unstructured":"Noorani, A., Vuylsteke, A., Lewis, C., Parameshwar J. & Catarino P. A moribund athlete. Lance 380, 74 (2012).","journal-title":"Lance"},{"key":"BFsrep13361_CR14","first-page":"1017.e1","volume":"30","author":"S Ghassam","year":"2012","unstructured":"Ghassam, S. et al. Successful extracorporeal membrane oxygenation treatment for pheochromocytoma-induced acute cardiac failure. AJEM 30, 1017.e1\u20131017.e3 (2012).","journal-title":"AJEM"},{"key":"BFsrep13361_CR15","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/j.athoracsur.2011.09.018","volume":"93","author":"C Banfi","year":"2012","unstructured":"Banfi, C. et al. Central extracorporeal life support in pheochromocytoma crisis. Ann Thorac Surg 93, 1303\u20131305 (2012).","journal-title":"Ann Thorac Surg"},{"key":"BFsrep13361_CR16","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1053\/j.jvca.2011.10.003","volume":"26","author":"R Sheinberg","year":"2012","unstructured":"Sheinberg, R. et al. Case 1\u20132012. A perfect storm: fatality resulting from metoclopramide unmasking a pheochromocytoma and its management. J Cardiothorac Vasc Anesth 26, 161\u2013115 (2012).","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"BFsrep13361_CR17","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/BF01709751","volume":"22","author":"JL Vincent","year":"1996","unstructured":"Vincent, J. L. et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22, 707\u2013710 (1996).","journal-title":"Intensive Care Med"},{"key":"BFsrep13361_CR18","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1093\/ajh\/3.5.360","volume":"3","author":"DH Streeten","year":"1990","unstructured":"Streeten, D. H., Anderson, G. H. Jr. & Wagner, S. Effect of age on response of secondary hypertension to specific treatment. Am J Hypertens 3, 360\u2013365 (1990).","journal-title":"Am J Hypertens"},{"key":"BFsrep13361_CR19","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1136\/pgmj.2006.049445","volume":"83","author":"T Kearney","year":"2007","unstructured":"Kearney, T. & Dang, C. Diabetic and endocrine emergencies. Postgrad Med J 83, 79\u201386 (2007).","journal-title":"Postgrad Med J"},{"key":"BFsrep13361_CR20","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0749-0704(05)70152-4","volume":"17","author":"MD Ringel","year":"2001","unstructured":"Ringel, M. D. Management of hypothyroidism and hyperthyroidism in the intensive care unit. Crit Care Clin 17, 59\u201374 (2001).","journal-title":"Crit Care Clin"},{"key":"BFsrep13361_CR21","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/j.1445-5994.2009.02095.x","volume":"40","author":"D Lutchman","year":"2010","unstructured":"Lutchman, D., Buchholz, S. & Keightley, C. Pheochromocytoma\u2013associated critical peripheral ischemia. Intern Med J 40, 150\u2013159 (2010).","journal-title":"Intern Med J"},{"key":"BFsrep13361_CR22","doi-asserted-by":"publisher","first-page":"478","DOI":"10.4158\/EP.13.5.476","volume":"13","author":"K Hull","year":"2007","unstructured":"Hull, K. et al. Two cases of thyroid storm-associated cholestatic jaundice. Endocr Pract 13, 478\u2013480 (2007).","journal-title":"Endocr Pract"},{"key":"BFsrep13361_CR23","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1177\/000348941312201103","volume":"22","author":"C Hambleton","year":"2013","unstructured":"Hambleton, C. et al. Thyroid storm complicated by fulminant hepatic failure: Case report and literature review. Ann Otol Rhinol Laryngol 22, 679\u2013682 (2013).","journal-title":"Ann Otol Rhinol Laryngol"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep13361","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep13361.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep13361.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T22:52:42Z","timestamp":1672959162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep13361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,24]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,10,16]]}},"alternative-id":["BFsrep13361"],"URL":"https:\/\/doi.org\/10.1038\/srep13361","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,24]]},"assertion":[{"value":"26 March 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"13361"}}