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Mechanisms of immune evasion by the parasite, including antigenic variation and surface masking, have been implicated but not well defined. In this study, we defined the immunoglobulin-binding proteomes of <jats:italic>S. japonicum<\/jats:italic> using human IgG, IgM and IgE as the molecular bait for affinity purification, followed by protein identification by liquid chromatography with tandem mass spectrometry (LC-MS\/MS). Several proteins situated at the tegument of <jats:italic>S. japonicum<\/jats:italic> were able to nonselectively bind to the Fc domain of host immunoglobulins, indicating a mechanism for the avoidance of host immune attachment and recognition. The profile of the immunoglobulin-binding proteomes provides further clues for immune evasion mechanisms adopted by <jats:italic>S. japonicum<\/jats:italic>.<\/jats:p>","DOI":"10.1038\/srep13434","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T09:26:13Z","timestamp":1440408373000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Non-immune immunoglobulins shield Schistosoma japonicum from host immunorecognition"],"prefix":"10.1038","volume":"5","author":[{"given":"Chuang","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianyu","family":"Piao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,8,24]]},"reference":[{"key":"BFsrep13434_CR1","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","volume":"6","author":"P Steinmann","year":"2006","unstructured":"Steinmann, P., Keiser, J., Bos, R., Tanner, M. & Utzinger, J. 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