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Recent clinical data suggest that chronic use of these drugs increases the frequency of new onset diabetes. Studies to define the risks of statin-induced diabetes and its underlying mechanisms are clearly necessary. We explored the possible mechanism of statin induced insulin resistance using a well-established cell based model and simvastatin as a prototype statin. Our data show that simvastatin induces insulin resistance in a cholesterol biosynthesis inhibition independent fashion but does so by a fatty acid mediated effect on insulin signaling pathway. These data may help design strategies for prevention of statin induced insulin resistance and diabetes in patients with hypercholesterolemia.<\/jats:p>","DOI":"10.1038\/srep13823","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T05:30:29Z","timestamp":1441690229000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism"],"prefix":"10.1038","volume":"5","author":[{"given":"Vasundhara","family":"Kain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bandish","family":"Kapadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parimal","family":"Misra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uday","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,9,8]]},"reference":[{"key":"BFsrep13823_CR1","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/S0140-6736(86)90598-2","volume":"2","author":"MJ Mol","year":"1986","unstructured":"Mol, M. 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