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The aim of this study was to investigate the associations between genetic variants in the interleukin (IL) and interleukin receptor (ILR) genes <jats:italic>IL-33<\/jats:italic>, <jats:italic>IL-1RL1<\/jats:italic>, <jats:italic>IL-23R<\/jats:italic> and signal transducer and activator of transcription 4 (<jats:italic>STAT4<\/jats:italic>) and susceptibility to gout in Chinese Han male individuals. The genetic distributions of rs3939286 in <jats:italic>IL-33<\/jats:italic>, rs13015714 in <jats:italic>IL-1RL1<\/jats:italic>, rs10889677 in <jats:italic>IL-23R<\/jats:italic> and rs7574865 in <jats:italic>STAT4<\/jats:italic> were detected in 1100 men with gout and 1227 ethnically matched controls, using Taqman allelic discrimination real-time polymerase chain reaction (PCR). Differences in these polymorphisms between the groups were investigated using \u03c7<jats:sup>2<\/jats:sup> tests. The genotype-phenotype relationship among gout patients was tested by analysis of variance. There was a significant difference in genotypic frequencies of IL-23R rs10889677 between gout patients and controls (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u200981.386, P\u2009&lt;\u20090.001). However, there were no significant differences in distributions of the other polymorphisms between the groups. Our results revealed that the rs10889677 variant in <jats:italic>IL-23R<\/jats:italic> may be involved in the development of gout in Chinese Han male individuals. However, further studies in other ethnic groups are needed to confirm these results.<\/jats:p>","DOI":"10.1038\/srep13887","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T09:08:29Z","timestamp":1443085709000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Associations between interleukin and interleukin receptor gene polymorphisms and risk of gout"],"prefix":"10.1038","volume":"5","author":[{"given":"Shiguo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changgui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,9,24]]},"reference":[{"key":"BFsrep13887_CR1","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1136\/annrheumdis-2013-204647","volume":"73","author":"E Smith","year":"2014","unstructured":"Smith, E. et al. 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