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During studying the Cu<jats:sup>2+<\/jats:sup>-chelating treatment of Cu<jats:sup>2+<\/jats:sup>-bound A\u03b2<jats:sub>42<\/jats:sub> aggregates, we found that UV light exposure pronouncedly enhances cytotoxicity of the chelator-treated and -untreated Cu<jats:sup>2+<\/jats:sup>-bound A\u03b2<jats:sub>42<\/jats:sub> aggregates. This stimulated us to thoroughly investigate (1) either the chelation treatment or UV light exposure leads to the increased cytotoxicity of the aggregates and (2) why the chelator-treated and -untreated Cu<jats:sup>2+<\/jats:sup>-bound A\u03b2<jats:sub>42<\/jats:sub> aggregates exhibit the increased cytotoxicity following UV light exposure if the latter is the case. The data indicated that the controlled UV exposure induced the dissociation of Cu<jats:sup>2+<\/jats:sup>-free and -bound A\u03b2<jats:sub>42<\/jats:sub> aggregates into SDS-stable soluble oligomers and the production of ROS including H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> in an UV light intensity- and time-dependent, but Cu<jats:sup>2+<\/jats:sup> chelation-independent manner. Although we can\u2019t fully understand the meaning of this finding at the current stage, the fact that the UV illuminated A\u03b2<jats:sub>42<\/jats:sub> aggregates can efficiently kill HeLa cells implies that the aggregates after UV light exposure could be used to decrease the viability of skin cancer cells through skin administration.<\/jats:p>","DOI":"10.1038\/srep13897","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T09:56:17Z","timestamp":1441792577000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ultraviolet light triggers the conversion of Cu2+-bound A\u03b242 aggregates into cytotoxic species in a copper chelation-independent manner"],"prefix":"10.1038","volume":"5","author":[{"given":"Xiongwei","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaojing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,9,9]]},"reference":[{"key":"BFsrep13897_CR1","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1002\/anie.201308001","volume":"53","author":"A Taniguchi","year":"2014","unstructured":"Taniguchi, A. et al. 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