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Nkx2.5 is expressed in the early heart (E7.5) and later in the tongue epithelium. Mice homozygous for deletion of NM II-A (A<jats:sup>Nkx<\/jats:sup>\/A<jats:sup>Nkx<\/jats:sup>) are born at the expected ratio with normal hearts, but consistently develop an invasive squamous cell carcinoma (SCC) of the tongue (32\/32 A<jats:sup>Nkx<\/jats:sup>\/A<jats:sup>Nkx<\/jats:sup>) as early as E17.5. To assess reproducibility a second, independent line of Myh9 floxed mice derived from a different embryonic stem cell clone was tested. This second line also develops SCC indistinguishable from the first (15\/15). In A<jats:sup>Nkx<\/jats:sup>\/A<jats:sup>Nkx<\/jats:sup> mouse tongue epithelium, genetic deletion of NM II-A does not affect stabilization of TP53, unlike a previous report for SCC. We attribute the consistent, early formation of SCC with high penetrance to the role of NM II in maintaining mitotic stability during karyokinesis.<\/jats:p>","DOI":"10.1038\/srep14068","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T08:49:53Z","timestamp":1442306993000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinoma"],"prefix":"10.1038","volume":"5","author":[{"given":"Mary","family":"Anne Conti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D.","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren R.","family":"Brinster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaleeka","family":"Cornelius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carter","family":"Van Waes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Adelstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,9,15]]},"reference":[{"key":"BFsrep14068_CR1","doi-asserted-by":"publisher","first-page":"41263","DOI":"10.1074\/jbc.C400352200","volume":"279","author":"MA Conti","year":"2004","unstructured":"Conti, M. 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