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This study investigated persistence and transmission dynamics of ON1 by grouping 406 randomly selected RSV-positive specimens submitted to Public Health Ontario from August 2011 to August 2012; RSV-A-positive specimens were genotyped. We identified 370 RSV-A (181 NA1, 135 NA2, 51 ON1 3 GA5) and 36 RSV-B positive specimens. We aligned time-stamped second hypervariable region (330\u2009bp) of G-gene sequence data (global, n\u2009=\u2009483; and Ontario, n\u2009=\u200960) to evaluate transmission dynamics. Global data suggests that the most recent common ancestor of ON1 emerged during the 2008\u20132009 season. Mean evolutionary rate of the global ON1 was 4.10\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>substitutions\/site\/year (95% BCI 3.1\u20135.0\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>), not significantly different to that of Ontario ON1. The estimated mean reproductive number (<jats:italic>R<\/jats:italic><jats:sub><jats:italic>0<\/jats:italic><\/jats:sub>\u2009=\u2009\u223c\u20091.01) from global and Ontario sequences showed no significant difference and implies stability among global RSV-A ON1. This study suggests that local epidemics exhibit similar underlying evolutionary and epidemiological dynamics to that of the persistent global RSV-A ON1 population. These findings underscore the importance of continual molecular surveillance of RSV in order to gain a better understanding of epidemics.<\/jats:p>","DOI":"10.1038\/srep14268","type":"journal-article","created":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T08:56:12Z","timestamp":1443603372000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Genetic diversity and evolutionary insights of respiratory syncytial virus A ON1 genotype: global and local transmission dynamics"],"prefix":"10.1038","volume":"5","author":[{"given":"Venkata R.","family":"Duvvuri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Granados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Rosenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Bahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Eshaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan B.","family":"Gubbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,9,30]]},"reference":[{"key":"BFsrep14268_CR1","doi-asserted-by":"publisher","first-page":"e51439","DOI":"10.1371\/journal.pone.0051439","volume":"7","author":"L Tan","year":"2012","unstructured":"Tan, L. et al. 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