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Enterovirus 71 (EV71) is one of primary pathogens that cause hand-foot-mouth disease. Here, we identify RelA(p65) as a novel binding partner for EV71 2C protein from yeast two-hybrid screen. By interaction with IPT domain of p65, 2C reduces the formation of heterodimer p65\/p50, the predominant form of NF-\u03baB. We also show that picornavirus 2C family proteins inhibit NF-\u03baB activation and associate with p65 and IKK\u03b2. Our findings provide a novel mechanism how EV71 antagonizes innate immunity.<\/jats:p>","DOI":"10.1038\/srep14302","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T09:23:27Z","timestamp":1443000207000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Enterovirus 71 2C Protein Inhibits NF-\u03baB Activation by Binding to RelA(p65)"],"prefix":"10.1038","volume":"5","author":[{"given":"Haiwei","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiqi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,9,23]]},"reference":[{"key":"BFsrep14302_CR1","doi-asserted-by":"publisher","first-page":"19780","DOI":"10.3402\/ehtj.v6i0.19780","volume":"6","author":"CC Yip","year":"2013","unstructured":"Yip, C. 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