{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:43:24Z","timestamp":1790023404885,"version":"4.0.1"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T00:00:00Z","timestamp":1444780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T00:00:00Z","timestamp":1444780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Methamphetamine (METH) is a widely abused psychostimulant with the potential to cause neurotoxicity in the striatum and hippocampus. Several epigenetic changes have been described after administration of METH; however, there are no data regarding the effects of METH on the activity of transposable elements in the adult brain. The present study demonstrates that systemic administration of neurotoxic METH doses increases the activity of Long INterspersed Element (LINE-1) in two neurogenic niches in the adult rat brain in a promoter hypomethylation-independent manner. Our study also demonstrates that neurotoxic METH triggers persistent decreases in LINE-1 expression and increases the LINE-1 levels within genomic DNA in the striatum and dentate gyrus of the hippocampus and that METH triggers LINE-1 retrotransposition <jats:italic>in vitro.<\/jats:italic> We also present indirect evidence for the involvement of glutamate (GLU) in LINE-1 activation. The results suggest that LINE-1 activation might occur in neurogenic areas in human METH users and might contribute to METH abuse-induced hippocampus-dependent memory deficits and impaired performance on several cognitive tasks mediated by the striatum.<\/jats:p>","DOI":"10.1038\/srep14356","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T09:22:19Z","timestamp":1444814539000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Neurotoxic Methamphetamine Doses Increase LINE-1 Expression in the Neurogenic Zones of the Adult Rat Brain"],"prefix":"10.1038","volume":"5","author":[{"given":"Anna","family":"Moszczynska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Flack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alysson R.","family":"Muotri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan A.","family":"Killinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,14]]},"reference":[{"key":"BFsrep14356_CR1","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/npp.2011.276","volume":"37","author":"CL Hart","year":"2012","unstructured":"Hart, C. L., Marvin, C. B., Silver, R. & Smith, E. E. Is cognitive functioning impaired in methamphetamine users? A critical review. Neuropsychopharmacology 37, 586\u2013608 (2012).","journal-title":"Neuropsychopharmacology"},{"key":"BFsrep14356_CR2","first-page":"198","volume":"170","author":"JR Richards","year":"1999","unstructured":"Richards, J. R. et al. Methamphetamine abuse and emergency department utilization. West J Med 170, 198\u2013202 (1999).","journal-title":"West J Med"},{"key":"BFsrep14356_CR3","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1749-6632.2009.05141.x","volume":"1187","author":"BK Yamamoto","year":"2010","unstructured":"Yamamoto, B. K., Moszczynska, A. & Gudelsky, G. A. Amphetamine toxicities: classical and emerging mechanisms. Ann N Y Acad Sci 1187, 101\u201321 (2010).","journal-title":"Ann N Y Acad Sci"},{"key":"BFsrep14356_CR4","doi-asserted-by":"publisher","first-page":"241","DOI":"10.2152\/jmi.55.241","volume":"55","author":"I Tokunaga","year":"2008","unstructured":"Tokunaga, I., Ishigami, A., Kubo, S., Gotohda, T. & Kitamura, O. The peroxidative DNA damage and apoptosis in methamphetamine-treated rat brain. J Med Invest 55, 241\u20135 (2008).","journal-title":"J Med Invest"},{"key":"BFsrep14356_CR5","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1096\/fj.03-0295com","volume":"18","author":"S Jayanthi","year":"2004","unstructured":"Jayanthi, S., Deng, X., Noailles, P. A., Ladenheim, B. & Cadet, J. L. Methamphetamine induces neuronal apoptosis via cross-talks between endoplasmic reticulum and mitochondria-dependent death cascades. FASEB J 18, 238\u201351 (2004).","journal-title":"FASEB J"},{"key":"BFsrep14356_CR6","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00414-006-0087-9","volume":"121","author":"O Kitamura","year":"2007","unstructured":"Kitamura, O., Tokunaga, I., Gotohda, T. & Kubo, S. Immunohistochemical investigation of dopaminergic terminal markers and caspase-3 activation in the striatum of human methamphetamine users. Int J Legal Med 121, 163\u20138 (2007).","journal-title":"Int J Legal Med"},{"key":"BFsrep14356_CR7","doi-asserted-by":"publisher","first-page":"e28946","DOI":"10.1371\/journal.pone.0028946","volume":"6","author":"G Beauvais","year":"2011","unstructured":"Beauvais, G., Atwell, K., Jayanthi, S., Ladenheim, B. & Cadet, J. L. Involvement of dopamine receptors in binge methamphetamine-induced activation of endoplasmic reticulum and mitochondrial stress pathways. PLoS One 6, e28946, 10.1371\/journal.pone.0028946 (2011).","journal-title":"PLoS One"},{"key":"BFsrep14356_CR8","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S0169-328X(01)00184-X","volume":"93","author":"X Deng","year":"2001","unstructured":"Deng, X., Wang, Y., Chou, J. & Cadet, J. L. Methamphetamine causes widespread apoptosis in the mouse brain: evidence from using an improved TUNEL histochemical method. Brain Res Mol Brain Res 93, 64\u20139 (2001).","journal-title":"Brain Res Mol Brain Res"},{"key":"BFsrep14356_CR9","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.biopsych.2008.04.010","volume":"64","author":"CD Mandyam","year":"2008","unstructured":"Mandyam, C. D. et al. Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis. Biol Psychiatry 64, 958\u201365 (2008).","journal-title":"Biol Psychiatry"},{"key":"BFsrep14356_CR10","doi-asserted-by":"publisher","first-page":"6028","DOI":"10.1523\/JNEUROSCI.0713-04.2004","volume":"24","author":"PM Thompson","year":"2004","unstructured":"Thompson, P. M. et al. Structural abnormalities in the brains of human subjects who use methamphetamine. J Neurosci 24, 6028\u201336 (2004).","journal-title":"J Neurosci"},{"key":"BFsrep14356_CR11","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s10571-010-9512-1","volume":"30","author":"N Hori","year":"2010","unstructured":"Hori, N. et al. Neurotoxic effects of methamphetamine on rat hippocampus pyramidal neurons. Cell Mol Neurobiol 30, 849\u201356 (2010).","journal-title":"Cell Mol Neurobiol"},{"key":"BFsrep14356_CR12","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s007020050012","volume":"107","author":"G Teuchert-Noodt","year":"2000","unstructured":"Teuchert-Noodt, G., Dawirs, R. R. & Hildebrandt, K. Adult treatment with methamphetamine transiently decreases dentate granule cell proliferation in the gerbil hippocampus. J Neural Transm 107, 133\u201343 (2000).","journal-title":"J Neural Transm"},{"key":"BFsrep14356_CR13","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1111\/j.1460-9568.2009.06759.x","volume":"29","author":"LJ Kochman","year":"2009","unstructured":"Kochman, L. J., Fornal, C. A. & Jacobs, B. L. Suppression of hippocampal cell proliferation by short-term stimulant drug administration in adult rats. Eur J Neurosci 29, 2157\u201365 (2009).","journal-title":"Eur J Neurosci"},{"key":"BFsrep14356_CR14","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.expneurol.2007.05.023","volume":"207","author":"R Kuczenski","year":"2007","unstructured":"Kuczenski, R. et al. Escalating dose-multiple binge methamphetamine exposure results in degeneration of the neocortex and limbic system in the rat. Exp Neurol 207, 42\u201351 (2007).","journal-title":"Exp Neurol"},{"key":"BFsrep14356_CR15","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1176\/appi.ajp.158.3.377","volume":"158","author":"ND Volkow","year":"2001","unstructured":"Volkow, N. D. et al. Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers. Am J Psychiatry 158, 377\u201382 (2001).","journal-title":"Am J Psychiatry"},{"key":"BFsrep14356_CR16","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1080\/15592294.2015.1055441","volume":"10","author":"A Godino","year":"2015","unstructured":"Godino, A., Jayanthi, S. & Cadet, J. L. Epigenetic landscape of amphetamine and methamphetamine addiction in rodents. Epigenetics 10, 574\u2013800 (2015).","journal-title":"Epigenetics"},{"key":"BFsrep14356_CR17","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.bbr.2007.03.027","volume":"181","author":"A Kalda","year":"2007","unstructured":"Kalda, A., Heidmets, L. T., Shen, H. Y., Zharkovsky, A. & Chen, J. F. Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice. Behav Brain Res 181, 76\u201384 (2007).","journal-title":"Behav Brain Res"},{"key":"BFsrep14356_CR18","doi-asserted-by":"publisher","first-page":"7344","DOI":"10.1523\/JNEUROSCI.1043-08.2008","volume":"28","author":"W Renthal","year":"2008","unstructured":"Renthal, W. et al. Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. J Neurosci 28, 7344\u20139 (2008).","journal-title":"J Neurosci"},{"key":"BFsrep14356_CR19","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1196\/annals.1316.013","volume":"1025","author":"Y Numachi","year":"2004","unstructured":"Numachi, Y. et al. Psychostimulant alters expression of DNA methyltransferase mRNA in the rat brain. Ann N Y Acad Sci 1025, 102\u20139 (2004).","journal-title":"Ann N Y Acad Sci"},{"key":"BFsrep14356_CR20","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/npp.2012.169","volume":"38","author":"JL Cadet","year":"2013","unstructured":"Cadet, J. L. & Jayanthi, S. Epigenetics of methamphetamine-induced changes in glutamate function. Neuropsychopharmacology 38, 248\u20139 (2013).","journal-title":"Neuropsychopharmacology"},{"key":"BFsrep14356_CR21","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1186\/1471-2164-14-545","volume":"14","author":"JL Cadet","year":"2013","unstructured":"Cadet, J. L. et al. Genome-wide profiling identifies a subset of methamphetamine (METH)-induced genes associated with METH-induced increased H4K5Ac binding in the rat striatum. BMC Genomics 14, 545 (2013).","journal-title":"BMC Genomics"},{"key":"BFsrep14356_CR22","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.biopsych.2013.09.034","volume":"76","author":"S Jayanthi","year":"2014","unstructured":"Jayanthi, S. et al. Methamphetamine downregulates striatal glutamate receptors via diverse epigenetic mechanisms. Biol Psychiatry 76, 47\u201356 (2014).","journal-title":"Biol Psychiatry"},{"key":"BFsrep14356_CR23","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1083\/jcb.201103006","volume":"194","author":"G Lippi","year":"2011","unstructured":"Lippi, G. et al. Targeting of the Arpc3 actin nucleation factor by miR-29a\/b regulates dendritic spine morphology. J Cell Biol 194, 889\u2013904 (2011).","journal-title":"J Cell Biol"},{"key":"BFsrep14356_CR24","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1128\/MCB.05896-11","volume":"32","author":"R Saba","year":"2012","unstructured":"Saba, R. et al. Dopamine-regulated microRNA MiR-181a controls GluA2 surface expression in hippocampal neurons. Mol Cell Biol 32, 619\u201332 (2012).","journal-title":"Mol Cell Biol"},{"key":"BFsrep14356_CR25","doi-asserted-by":"publisher","first-page":"17657","DOI":"10.1073\/pnas.1215810109","volume":"109","author":"RG Hunter","year":"2012","unstructured":"Hunter, R. G. et al. Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response. Proc Natl Acad Sci USA 109, 17657\u201362 (2012).","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFsrep14356_CR26","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.nbd.2013.05.009","volume":"58","author":"IN Krasnova","year":"2013","unstructured":"Krasnova, I. N. et al. CREB phosphorylation regulates striatal transcriptional responses in the self-administration model of methamphetamine addiction in the rat. Neurobiol Dis 58, 132\u201343 (2013).","journal-title":"Neurobiol Dis"},{"key":"BFsrep14356_CR27","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1007\/s12035-014-8776-8","volume":"51","author":"JL Cadet","year":"2014","unstructured":"Cadet, J. L., Brannock, C., Jayanthi, S. & Krasnova, I. N. Transcriptional and Epigenetic Substrates of Methamphetamine Addiction and Withdrawal: Evidence from a Long-Access Self-Administration Model in the Rat. Mol Neurobiol 51, 696\u2013717 (2014).","journal-title":"Mol Neurobiol"},{"key":"BFsrep14356_CR28","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuro.2014.10.008","volume":"45","author":"O Omonijo","year":"2014","unstructured":"Omonijo, O. et al. Differential effects of binge methamphetamine injections on the mRNA expression of histone deacetylases (HDACs) in the rat striatum. Neurotoxicology 45, 178\u201384 (2014).","journal-title":"Neurotoxicology"},{"key":"BFsrep14356_CR29","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.ejphar.2014.10.043","volume":"745","author":"W Jiang","year":"2014","unstructured":"Jiang, W., Li, J., Zhang, Z., Wang, H. & Wang, Z. Epigenetic upregulation of alpha-synuclein in the rats exposed to methamphetamine. Eur J Pharmacol 745, 243\u20138 (2014).","journal-title":"Eur J Pharmacol"},{"key":"BFsrep14356_CR30","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.1073\/pnas.1015483108","volume":"108","author":"I Maze","year":"2011","unstructured":"Maze, I. et al. Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens. Proc Natl Acad Sci USA 108, 3035\u201340 (2011).","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFsrep14356_CR31","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0378-1119(96)00856-6","volume":"189","author":"K Hata","year":"1997","unstructured":"Hata, K. & Sakaki, Y. Identification of critical CpG sites for repression of L1 transcription by DNA methylation. Gene 189, 227\u201334 (1997).","journal-title":"Gene"},{"key":"BFsrep14356_CR32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.mrfmmm.2009.02.011","volume":"665","author":"DE Montoya-Durango","year":"2009","unstructured":"Montoya-Durango, D. E. et al. Epigenetic control of mammalian LINE-1 retrotransposon by retinoblastoma proteins. Mutat Res 665, 20\u20138 (2009).","journal-title":"Mutat Res"},{"key":"BFsrep14356_CR33","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.2741\/e488","volume":"4","author":"CA Thomas","year":"2012","unstructured":"Thomas, C. A. & Muotri, A. R. LINE-1: creators of neuronal diversity. Front Biosci (Elite Ed) 4, 1663\u20138 (2012).","journal-title":"Front Biosci (Elite Ed)"},{"key":"BFsrep14356_CR34","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nrn3730","volume":"15","author":"JA Erwin","year":"2014","unstructured":"Erwin, J. A., Marchetto, M. C. & Gage, F. H. Mobile DNA elements in the generation of diversity and complexity in the brain. Nat Rev Neurosci 15, 497\u2013506 (2014).","journal-title":"Nat Rev Neurosci"},{"key":"BFsrep14356_CR35","doi-asserted-by":"publisher","first-page":"25476","DOI":"10.1074\/jbc.M114.559419","volume":"289","author":"N Okudaira","year":"2014","unstructured":"Okudaira, N., Ishizaka, Y. & Nishio, H. Retrotransposition of long interspersed element 1 induced by methamphetamine or cocaine. J Biol Chem 289, 25476\u201385 (2014).","journal-title":"J Biol Chem"},{"key":"BFsrep14356_CR36","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1038\/nature03663","volume":"435","author":"AR Muotri","year":"2005","unstructured":"Muotri, A. R. et al. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature 435, 903\u201310 (2005).","journal-title":"Nature"},{"key":"BFsrep14356_CR37","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1146\/annurev-cellbio-101011-155822","volume":"28","author":"CA Thomas","year":"2012","unstructured":"Thomas, C. A., Paquola, A. C. & Muotri, A. R. LINE-1 retrotransposition in the nervous system. Annu Rev Cell Dev Biol 28, 555\u201373 (2012).","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BFsrep14356_CR38","doi-asserted-by":"publisher","first-page":"9233","DOI":"10.1093\/nar\/16.19.9233","volume":"16","author":"I Nur","year":"1988","unstructured":"Nur, I., Pascale, E. & Furano, A. V. The left end of rat L1 (L1Rn, long interspersed repeated) DNA which is a CpG island can function as a promoter. Nucleic Acids Res 16, 9233\u201351 (1988).","journal-title":"Nucleic Acids Res"},{"key":"BFsrep14356_CR39","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.brainres.2007.09.028","volume":"1185","author":"S Vergo","year":"2007","unstructured":"Vergo, S., Johansen, J. L., Leist, M. & Lotharius, J. Vesicular monoamine transporter 2 regulates the sensitivity of rat dopaminergic neurons to disturbed cytosolic dopamine levels. Brain Res 1185, 18\u201332 (2007).","journal-title":"Brain Res"},{"key":"BFsrep14356_CR40","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1124\/mol.114.091728","volume":"85","author":"M Trivedi","year":"2014","unstructured":"Trivedi, M., Shah, J., Hodgson, N., Byun, H. M. & Deth, R. Morphine induces redox-based changes in global DNA methylation and retrotransposon transcription by inhibition of excitatory amino acid transporter type 3-mediated cysteine uptake. Mol Pharmacol 85, 747\u201357 (2014).","journal-title":"Mol Pharmacol"},{"key":"BFsrep14356_CR41","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1523\/JNEUROSCI.3136-11.2012","volume":"32","author":"I Ponomarev","year":"2012","unstructured":"Ponomarev, I., Wang, S., Zhang, L., Harris, R. A. & Mayfield, R. D. Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence. J Neurosci 32, 1884\u201397 (2012).","journal-title":"J Neurosci"},{"key":"BFsrep14356_CR42","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/0896-6273(89)90043-3","volume":"2","author":"TH Murphy","year":"1989","unstructured":"Murphy, T. H., Miyamoto, M., Sastre, A., Schnaar, R. L. & Coyle, J. T. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron 2, 1547\u201358 (1989).","journal-title":"Neuron"},{"key":"BFsrep14356_CR43","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1046\/j.1471-4159.2001.00549.x","volume":"79","author":"MR Gluck","year":"2001","unstructured":"Gluck, M. R. et al. Parallel increases in lipid and protein oxidative markers in several mouse brain regions after methamphetamine treatment. J Neurochem 79, 152\u201360 (2001).","journal-title":"J Neurochem"},{"key":"BFsrep14356_CR44","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0304-3940(98)00711-3","volume":"255","author":"A Moszczynska","year":"1998","unstructured":"Moszczynska, A., Turenne, S. & Kish, S. J. Rat striatal levels of the antioxidant glutathione are decreased following binge administration of methamphetamine. Neurosci Lett 255, 49\u201352 (1998).","journal-title":"Neurosci Lett"},{"key":"BFsrep14356_CR45","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1385\/NMM:2:1:71","volume":"2","author":"G Flora","year":"2002","unstructured":"Flora, G. et al. Methamphetamine-induced TNF-alpha gene expression and activation of AP-1 in discrete regions of mouse brain: potential role of reactive oxygen intermediates and lipid peroxidation. Neuromolecular Med 2, 71\u201385 (2002).","journal-title":"Neuromolecular Med"},{"key":"BFsrep14356_CR46","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1016\/j.neuropharm.2012.02.015","volume":"62","author":"S Baptista","year":"2012","unstructured":"Baptista, S. et al. Neuropeptide Y promotes neurogenesis and protection against methamphetamine-induced toxicity in mouse dentate gyrus-derived neurosphere cultures. Neuropharmacology 62, 2413\u201323 (2012).","journal-title":"Neuropharmacology"},{"key":"BFsrep14356_CR47","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.1111\/j.1460-9568.2012.08232.x","volume":"36","author":"J Goncalves","year":"2012","unstructured":"Goncalves, J., Ribeiro, C. F., Malva, J. O. & Silva, A. P. Protective role of neuropeptide Y Y(2) receptors in cell death and microglial response following methamphetamine injury. Eur J Neurosci 36, 3173\u201383 (2012).","journal-title":"Eur J Neurosci"},{"key":"BFsrep14356_CR48","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0006-8993(92)90713-J","volume":"581","author":"JF Nash","year":"1992","unstructured":"Nash, J. F. & Yamamoto, B. K. Methamphetamine neurotoxicity and striatal glutamate release: comparison to 3,4-methylenedioxymethamphetamine. Brain Res 581, 237\u201343 (1992).","journal-title":"Brain Res"},{"key":"BFsrep14356_CR49","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.brainres.2006.12.002","volume":"1135","author":"J Raudensky","year":"2007","unstructured":"Raudensky, J. & Yamamoto, B. K. Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function. Brain Res 1135, 129\u201335 (2007).","journal-title":"Brain Res"},{"key":"BFsrep14356_CR50","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s00441-011-1289-0","volume":"346","author":"G Giorgi","year":"2011","unstructured":"Giorgi, G., Marcantonio, P. & Del Re, B. LINE-1 retrotransposition in human neuroblastoma cells is affected by oxidative stress. Cell Tissue Res 346, 383\u201391 (2011).","journal-title":"Cell Tissue Res"},{"key":"BFsrep14356_CR51","doi-asserted-by":"publisher","first-page":"e74629","DOI":"10.1371\/journal.pone.0074629","volume":"8","author":"N Terasaki","year":"2013","unstructured":"Terasaki, N. et al. In vitro screening for compounds that enhance human L1 mobilization. PLoS One 8, e74629, 10.1371\/journal.pone.0074629 (2013).","journal-title":"PLoS One"},{"key":"BFsrep14356_CR52","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.bbr.2013.02.034","volume":"247","author":"AO Abdel-Zaher","year":"2013","unstructured":"Abdel-Zaher, A. O., Mostafa, M. G., Farghaly, H. S., Hamdy, M. M. & Abdel-Hady, R. H. Role of oxidative stress and inducible nitric oxide synthase in morphine-induced tolerance and dependence in mice. Effect of alpha-lipoic acid. Behav Brain Res 247, 17\u201326 (2013).","journal-title":"Behav Brain Res"},{"key":"BFsrep14356_CR53","doi-asserted-by":"publisher","first-page":"79","DOI":"10.2174\/157015911795017281","volume":"9","author":"IK Tulloch","year":"2011","unstructured":"Tulloch, I. K., Afanador, L., Zhu, J. & Angulo, J. A. Methamphetamine induces striatal cell death followed by the generation of new cells and a second round of cell death in mice. Curr Neuropharmacol 9, 79\u201383 (2011).","journal-title":"Curr Neuropharmacol"},{"key":"BFsrep14356_CR54","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S1044-7431(03)00159-3","volume":"24","author":"K Jin","year":"2003","unstructured":"Jin, K. et al. Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum. Mol Cell Neurosci 24, 171\u201389 (2003).","journal-title":"Mol Cell Neurosci"},{"key":"BFsrep14356_CR55","doi-asserted-by":"publisher","first-page":"25018","DOI":"10.1074\/jbc.M110.111450","volume":"285","author":"A Vaarmann","year":"2010","unstructured":"Vaarmann, A., Gandhi, S. & Abramov, A. Y. Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase. J Biol Chem 285, 25018\u201323 (2010).","journal-title":"J Biol Chem"},{"key":"BFsrep14356_CR56","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1146\/annurev.cellbio.042308.113256","volume":"25","author":"H Suh","year":"2009","unstructured":"Suh, H., Deng, W. & Gage, F. H. Signaling in adult neurogenesis. Annu Rev Cell Dev Biol 25, 253\u201375 (2009).","journal-title":"Annu Rev Cell Dev Biol"},{"key":"BFsrep14356_CR57","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.jmb.2006.01.089","volume":"357","author":"SL Gasior","year":"2006","unstructured":"Gasior, S. L., Wakeman, T. P., Xu, B. & Deininger, P. L. The human LINE-1 retrotransposon creates DNA double-strand breaks. J Mol Biol 357, 1383\u201393 (2006).","journal-title":"J Mol Biol"},{"key":"BFsrep14356_CR58","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.gene.2008.04.013","volume":"419","author":"NA Wallace","year":"2008","unstructured":"Wallace, N. A., Belancio, V. P. & Deininger, P. L. L1 mobile element expression causes multiple types of toxicity. Gene 419, 75\u201381 (2008).","journal-title":"Gene"},{"key":"BFsrep14356_CR59","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1111\/1440-1681.12404","volume":"42","author":"Z Johnson","year":"2015","unstructured":"Johnson, Z., Venters, J., Guarraci, F. A. & Zewail-Foote, M. Methamphetamine induces DNA damage in specific regions of the female rat brain. Clin Exp Pharmacol Physiol 42, 570\u20135 (2015).","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"BFsrep14356_CR60","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1089\/rej.2010.1109","volume":"14","author":"AR Bento","year":"2011","unstructured":"Bento, A. R., Baptista, S., Malva, J. O., Silva, A. P. & Agasse, F. Methamphetamine exerts toxic effects on subventricular zone stem\/progenitor cells and inhibits neuronal differentiation. Rejuvenation Res 14, 205\u201314 (2011).","journal-title":"Rejuvenation Res"},{"key":"BFsrep14356_CR61","doi-asserted-by":"publisher","first-page":"37285","DOI":"10.1155\/JBB\/2006\/37285","volume":"2006","author":"EA Farkash","year":"2006","unstructured":"Farkash, E. A. & Luning Prak, E. T. DNA damage and L1 retrotransposition. J Biomed Biotechnol 2006, 37285 (2006).","journal-title":"J Biomed Biotechnol"},{"key":"BFsrep14356_CR62","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1177\/0960327112438287","volume":"31","author":"X Zhang","year":"2012","unstructured":"Zhang, X., Tobwala, S. & Ercal, N. N-acetylcysteine amide protects against methamphetamine-induced tissue damage in CD-1 mice. Hum Exp Toxicol 31, 931\u201344 (2012).","journal-title":"Hum Exp Toxicol"},{"key":"BFsrep14356_CR63","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1756-6606-4-28","volume":"4","author":"A Venkatesan","year":"2011","unstructured":"Venkatesan, A. et al. Impairment of adult hippocampal neural progenitor proliferation by methamphetamine: role for nitrotyrosination. Mol Brain 4, 28 (2011).","journal-title":"Mol Brain"},{"key":"BFsrep14356_CR64","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/nature08248","volume":"460","author":"NG Coufal","year":"2009","unstructured":"Coufal, N. G. et al. L1 retrotransposition in human neural progenitor cells. Nature 460, 1127\u201331 (2009).","journal-title":"Nature"},{"key":"BFsrep14356_CR65","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1093\/nar\/gki223","volume":"33","author":"HS Soifer","year":"2005","unstructured":"Soifer, H. S., Zaragoza, A., Peyvan, M., Behlke, M. A. & Rossi, J. J. A potential role for RNA interference in controlling the activity of the human LINE-1 retrotransposon. Nucleic Acids Res 33, 846\u201356 (2005).","journal-title":"Nucleic Acids Res"},{"key":"BFsrep14356_CR66","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/nature12686","volume":"503","author":"MC Marchetto","year":"2013","unstructured":"Marchetto, M. C. et al. Differential L1 regulation in pluripotent stem cells of humans and apes. Nature 503, 525\u20139 (2013).","journal-title":"Nature"},{"key":"BFsrep14356_CR67","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.4161\/rna.22402","volume":"9","author":"DK Singh","year":"2012","unstructured":"Singh, D. K. & Rath, P. C. Long interspersed nuclear elements (LINEs) show tissue-specific, mosaic genome and methylation-unrestricted, widespread expression of noncoding RNAs in somatic tissues of the rat. RNA Biol 9, 1380\u201396 (2012).","journal-title":"RNA Biol"},{"key":"BFsrep14356_CR68","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/nature10008","volume":"473","author":"G Ficz","year":"2011","unstructured":"Ficz, G. et al. Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature 473, 398\u2013402 (2011).","journal-title":"Nature"},{"key":"BFsrep14356_CR69","doi-asserted-by":"publisher","first-page":"201","DOI":"10.4161\/epi.7.2.19015","volume":"7","author":"J Yamazaki","year":"2012","unstructured":"Yamazaki, J. et al. Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia. Epigenetics 7, 201\u20137 (2012).","journal-title":"Epigenetics"},{"key":"BFsrep14356_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2009.12.083","volume":"1318","author":"G Beauvais","year":"2010","unstructured":"Beauvais, G., Jayanthi, S., McCoy, M. T., Ladenheim, B. & Cadet, J. L. Differential effects of methamphetamine and SCH23390 on the expression of members of IEG families of transcription factors in the rat striatum. Brain Res 1318, 1\u201310 (2010).","journal-title":"Brain Res"},{"key":"BFsrep14356_CR71","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1007\/s12035-014-8776-8","volume":"51","author":"JL Cadet","year":"2015","unstructured":"Cadet, J. L., Brannock, C., Jayanthi, S. & Krasnova, I. N. Transcriptional and epigenetic substrates of methamphetamine addiction and withdrawal: evidence from a long-access self-administration model in the rat. Mol Neurobiol 51, 696\u2013717 (2015).","journal-title":"Mol Neurobiol"},{"key":"BFsrep14356_CR72","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1006\/exnr.2002.8048","volume":"179","author":"G Flora","year":"2003","unstructured":"Flora, G. et al. Methamphetamine potentiates HIV-1 Tat protein-mediated activation of redox-sensitive pathways in discrete regions of the brain. Exp Neurol 179, 60\u201370 (2003).","journal-title":"Exp Neurol"},{"key":"BFsrep14356_CR73","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1152\/physiolgenomics.00251.2005","volume":"25","author":"E Lucchinetti","year":"2006","unstructured":"Lucchinetti, E. et al. Inhibition of LINE-1 expression in the heart decreases ischemic damage by activation of Akt\/PKB signaling. Physiol Genomics 25, 314\u201324 (2006).","journal-title":"Physiol Genomics"},{"key":"BFsrep14356_CR74","doi-asserted-by":"publisher","first-page":"6469","DOI":"10.1128\/MCB.00332-07","volume":"27","author":"JL Goodier","year":"2007","unstructured":"Goodier, J. L., Zhang, L., Vetter, M. R. & Kazazian, H. H., Jr. LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex. Mol Cell Biol 27, 6469\u201383 (2007).","journal-title":"Mol Cell Biol"},{"key":"BFsrep14356_CR75","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","volume":"8","author":"C Kilkenny","year":"2010","unstructured":"Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M. & Altman, D. G. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol 8, e1000412, 10.1371\/journal.pbio.1000412 (2010).","journal-title":"PLoS Biol"},{"key":"BFsrep14356_CR76","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.3791\/1543","volume":"33","author":"H Hagihara","year":"2009","unstructured":"Hagihara, H., Toyama, K., Yamasaki, N. & Miyakawa, T. Dissection of hippocampal dentate gyrus from adult mouse. J Vis Exp 33, pii: 1543, 10.3791\/1543 (2009).","journal-title":"J Vis Exp"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep14356","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep14356.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep14356.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:23:25Z","timestamp":1672964605000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep14356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,14]]},"references-count":76,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,11,26]]}},"alternative-id":["BFsrep14356"],"URL":"https:\/\/doi.org\/10.1038\/srep14356","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,14]]},"assertion":[{"value":"4 March 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14356"}}