{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:49:25Z","timestamp":1780087765217,"version":"3.54.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Benign prostatic hyperplasia (BPH) is one of the most common diseases in middle-aged and elderly men. In the present study, we aimed to compare the efficacy and safety of thulium laser resection of the prostate (TMLRP) with either transurethral plasmakinetic resection of the prostate (TUPKP) or transurethral resection of the prostate (TURP). A literature search was performed, eventually, 14 studies involving 1587 patients were included. Forest plots were produced by using Revman 5.2.0 software. Our meta-analysis showed that operation time, decrease in hemoglobin level, length of hospital stay, catheterization time and development of urethral stricture significantly differed, whereas the transitory urge incontinence rate, urinary tract infection rate and recatheterization rate did not significantly differ between TMLRP and either TURP or TUPKP. The blood transfusion rate was significantly different between TMLRP and TURP, but not between TMLRP and TUPKP. In addition, the retrograde ejaculation rate between TMLRP and TURP did not significantly differ. At 1, 3, 6 and 12 months of postoperative follow-up, the maximum flow rate, post-void residual, quality of life and International Prostate Symptom Score did not significantly differ among the procedures. Thus, the findings of this study indicate that TMLRP may be a safe and feasible alternative.<\/jats:p>","DOI":"10.1038\/srep14542","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T08:43:18Z","timestamp":1444207398000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparison between thulium laser resection of prostate and transurethral plasmakinetic resection of prostate or transurethral resection of prostate"],"prefix":"10.1038","volume":"5","author":[{"given":"Hong","family":"DeCao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"LiangLiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"JunLei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"YingHu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"JiuYuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,7]]},"reference":[{"key":"BFsrep14542_CR1","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.eururo.2013.03.004","volume":"64","author":"M Oelke","year":"2013","unstructured":"Oelke, M. et al. EAU Guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. Euro Urol 64, 118\u2013140 (2013).","journal-title":"Euro Urol"},{"key":"BFsrep14542_CR2","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.eururo.2008.10.034","volume":"55","author":"R Szlauer","year":"2009","unstructured":"Szlauer, R., G\u00f6tschl, R., Razmaria, A., Paras, L. & Schmeller, N. T. Endoscopic vaporesection of the prostate using the continuous-wave 2-\u03bcm thulium laser: outcome and demonstration of the surgical technique. Euro Urol 55, 368\u2013375 (2009).","journal-title":"Euro Urol"},{"key":"BFsrep14542_CR3","first-page":"1251","volume":"46","author":"EC Hwang","year":"2005","unstructured":"Hwang, E. C. et al. A short-term comparative study on efficacy and safety of standard transurethral resection and high power (80W) potassium-titanyl-phosphate laser vaportzation of the prostate. Korean J Urol 46, 1251\u20131255 (2005).","journal-title":"Korean J Urol"},{"key":"BFsrep14542_CR4","doi-asserted-by":"crossref","unstructured":"Netsch, C., Engbert, A., Bach, T. & Gross, A. Long-term outcome following Thulium VapoEnucleation of the prostate. World J Urol., 10.1007\/s00345-014-1260-2 (2014); [Epub ahead of print].","DOI":"10.1007\/s00345-014-1260-2"},{"key":"BFsrep14542_CR5","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.eururo.2012.11.048","volume":"63","author":"A Gross","year":"2013","unstructured":"Gross, A., Netsch, C., Knipper, S., H\u00f6lzel, J. & Bach, T. Complications and early postoperative outcome in 1080 Patients after thulium vapoenucleation of the prostate: results at a single institution. Euro Urol 63, 859\u2013867 (2013).","journal-title":"Euro Urol"},{"key":"BFsrep14542_CR6","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.eururo.2005.12.042","volume":"50","author":"J Rassweiler","year":"2006","unstructured":"Rassweiler, J., Teber, D., Kuntz, R. & Hofmann, R. Complications of transurethral resection of the prostate (TURP) \u2014 incidence, management and prevention. Eur Urol 50, 969\u2013980 (2006).","journal-title":"Eur Urol"},{"key":"BFsrep14542_CR7","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.juro.2008.03.058","volume":"180","author":"O Reich","year":"2008","unstructured":"Reich, O. et al. Urology Section of the Bavarian Working Group for Quality Assurance. Morbidity, mortality and early outcome of transurethral resection of the prostate: a prospective multicenter evaluation of 10,654 patients. J Urol 180, 246\u2013249 (2008).","journal-title":"J Urol"},{"key":"BFsrep14542_CR8","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1186\/1471-2482-12-S1-S22","volume":"12","author":"F Iacono","year":"2012","unstructured":"Iacono, F. et al. Efficacy and safety profile of a novel technique, ThuLEP (Thulium laser enucleation of the prostate) for the treatment of benign prostate hypertrophy. Our experience on 148 patients. BMC Surg 12, 1471\u20131472 (2012).","journal-title":"BMC Surg"},{"key":"BFsrep14542_CR9","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1159\/000336874","volume":"88","author":"S Hauser","year":"2012","unstructured":"Hauser, S. et al. Thulium laser (Revolix) vapoenucleation of the prostate is a safe procedure in patients with an increased risk of hemorrhage. Urol Int 88, 390\u2013394 (2012).","journal-title":"Urol Int"},{"key":"BFsrep14542_CR10","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1089\/end.2007.0421","volume":"22","author":"G Wendt-Nordahl","year":"2008","unstructured":"Wendt-Nordahl, G. et al. Systematic evaluation of a recently introduced 2-microm continuous-wave thulium laser for vaporesection of the prostate. J Endourol 22, 1041\u20131045 (2008).","journal-title":"J Endourol"},{"key":"BFsrep14542_CR11","doi-asserted-by":"publisher","first-page":"41","DOI":"10.4111\/kju.2014.55.1.41","volume":"55","author":"JW Kim","year":"2014","unstructured":"Kim, J. W. et al. An analytical comparison of short-term effectiveness and safety between thulium: YAG laser vaporesection of the prostate and bipolar transurethral resection of the prostate in patients with benign prostatic hyperplasia. Korean J Urol 55, 41\u201346 (2014).","journal-title":"Korean J Urol"},{"key":"BFsrep14542_CR12","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.urology.2012.08.069","volume":"81","author":"Z Yang","year":"2013","unstructured":"Yang, Z., Wang, X. & Liu, T. Thulium laser enucleation versus plasmakinetic resection of the prostate: a randomized prospective trial with 18-month follow-up. Urology 81, 396\u2013401 (2013).","journal-title":"Urology"},{"key":"BFsrep14542_CR13","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1007\/s00345-013-1210-4","volume":"32","author":"H Wei","year":"2014","unstructured":"Wei, H. et al. Thulium laser resection versus plasmakinetic resection of prostates larger than 80 ml. Word J Urol 32, 1077\u20131085 (2014).","journal-title":"Word J Urol"},{"key":"BFsrep14542_CR14","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1111\/j.1464-410X.2012.11610.x","volume":"111","author":"B Peng","year":"2013","unstructured":"Peng, B. et al. A comparative study of thulium laser resection of the prostate and bipolar transurethral plasmakinetic prostatectomy for treating benign prostatic hyperplasia. BJU Int 111, 633\u2013637 (2013).","journal-title":"BJU Int"},{"key":"BFsrep14542_CR15","first-page":"102","volume":"20","author":"CL Liu","year":"2011","unstructured":"Liu, C. L. et al. Thulium laser vaporesection of prostate versus transurethral plasmakinetic resection of prostate for BPH patients. Chin J Laser Med Surg 20, 102\u2013105 (2011).","journal-title":"Chin J Laser Med Surg"},{"key":"BFsrep14542_CR16","first-page":"44","volume":"13","author":"Q Wang","year":"2008","unstructured":"Wang, Q. et al. A comparative study on the results of transurethral thulium laser resection of prostate, transurethral plasmakinetic resection of prostate and transurethral electroresection of prostate for BPH. Xiandai Miniao Waike Zazhi 13, 44\u201347 (2008).","journal-title":"Xiandai Miniao Waike Zazhi"},{"key":"BFsrep14542_CR17","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/j.1442-2042.2012.03183.x","volume":"20","author":"H Yan","year":"2013","unstructured":"Yan, H. et al. Thulium laser vaporesection versus standard transurethral resection of the prostate: a randomized trial with transpulmonary thermodilution hemodynamic monitoring. Int J Urol 20, 507\u2013512 (2013).","journal-title":"Int J Urol"},{"key":"BFsrep14542_CR18","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s00345-013-1103-6","volume":"32","author":"D Cui","year":"2014","unstructured":"Cui, D. et al. A randomized trial comparing thulium laser resection to standard transurethral resection of the prostate for symptomatic benign prostatic hyperplasia: four-year follow-up results. World J Urol 32, 683\u2013689 (2014).","journal-title":"World J Urol"},{"key":"BFsrep14542_CR19","doi-asserted-by":"publisher","first-page":"130","DOI":"10.5173\/ceju.2012.03.art6","volume":"65","author":"PP \u015awiniarski","year":"2012","unstructured":"\u015awiniarski, P. P. et al. Thulium laser enucleation of the prostate (TmLEP) vs. transurethral resection of the prostate (TURP): evaluation of early results. Cent European J Urol 65, 130\u2013134 (2012).","journal-title":"Cent European J Urol"},{"key":"BFsrep14542_CR20","first-page":"131","volume":"50","author":"JK Shao","year":"2012","unstructured":"Shao, J. K., Wang, Y. B., L\u00fc, Y. A. & Li, X. D. Comparision of 2 \u03bcm continuous-wave laser enucleation of the prostate and transurethral resection of the prostate for benign prostatic hyperplasia. Chin J Surg 50, 131\u2013134 (2012).","journal-title":"Chin J Surg"},{"key":"BFsrep14542_CR21","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.urology.2009.07.1266","volume":"75","author":"WJ Fu","year":"2010","unstructured":"Fu, W. J. et al. Comparison of 2-\u03bcm continuous wave laser vaporesection of the prostate and transurethral resection of the prostate: a prospective nonrandomized trial with 1-year follow-up. Urology 75, 194\u2013199 (2010).","journal-title":"Urology"},{"key":"BFsrep14542_CR22","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.eururo.2007.05.019","volume":"53","author":"SJ Xia","year":"2008","unstructured":"Xia, S. J. et al. Thulium laser versus standard transurethral resection of the prostate: a randomized prospective trial. Eur Urol 53, 382\u2013389 (2008).","journal-title":"Eur Urol"},{"key":"BFsrep14542_CR23","first-page":"792","volume":"23","author":"Z Jia","year":"2009","unstructured":"Jia, Z. Control study on thulium laser orange-decorticating type of prostatectomy with transurethraI prostatic electric resection to treat patients with benign prostatic hyperplasia. Chin Nurs Res 23, 792\u2013793 (2009).","journal-title":"Chin Nurs Res"},{"key":"BFsrep14542_CR24","first-page":"38","volume":"28","author":"J Zhuo","year":"2007","unstructured":"Zhuo, J. et al. A comparative study of thulium laser resection of the prostate-tangerine technique and transurethral resection of the prostate for the treatment of benign prostatic hyperplasia. Chin J Urol 28, 38\u201341 (2007).","journal-title":"Chin J Urol"},{"key":"BFsrep14542_CR25","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/j.juro.2012.10.117","volume":"189","author":"L Zhu","year":"2013","unstructured":"Zhu, L. et al. Electrosurgical enucleation versus bipolar transurethral resection for prostates larger than 70 ml: a prospective, randomized trial with 5-year followup. J Urol 189, 1427\u20131431 (2013).","journal-title":"J Urol"},{"key":"BFsrep14542_CR26","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.urology.2011.08.052","volume":"79","author":"G Zhu","year":"2012","unstructured":"Zhu, G., Xie, C., Wang, X. & Tang, X. Bipolar plasmakinetic transurethral resection of prostate in 132 consecutive patients with large gland: three-year follow-up results. Urology 79, 397\u2013402 (2012).","journal-title":"Urology"},{"key":"BFsrep14542_CR27","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1100\/tsw.2007.241","volume":"7","author":"DS Finley","year":"2007","unstructured":"Finley, D. S., Beck, S., & Szabo, R. J. Bipolar saline TURP for large prostate glands. Sci World J 7, 1558\u20131562 (2007).","journal-title":"Sci World J"},{"key":"BFsrep14542_CR28","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s00345-008-0370-0","volume":"27","author":"T Bach","year":"2009","unstructured":"Bach, T., Wendt-Nordahl, G., Michel, M. S., Herrmann, T. R. & Gross, A. J. Feasibility and efficacy of Thulium:YAG laser enucleation (VapoEnucleation) of the prostate. World J Urol 27, 541\u2013545 (2009).","journal-title":"World J Urol"},{"key":"BFsrep14542_CR29","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1089\/end.2007.0421","volume":"22","author":"G Wendt-Nordahl","year":"2008","unstructured":"Wendt-Nordahl, G. et al. Systematic evaluation of a recently introduced 2-microm continuous-wave thulium laser for vaporesection of the prostate. J Endourol 22, 1041\u20131045 (2008).","journal-title":"J Endourol"},{"key":"BFsrep14542_CR30","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.eururo.2011.11.041","volume":"61","author":"A Bachmann","year":"2012","unstructured":"Bachmann, A. et al. 180-W XPS GreenLight laser therapy for benign prostate hyperplasia: early safety, efficacy and perioperative outcome after 201 procedures. Eur Urol 61, 600\u2013607 (2012).","journal-title":"Eur Urol"},{"key":"BFsrep14542_CR31","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1089\/end.2005.19.25","volume":"19","author":"NM Fried","year":"2005","unstructured":"Fried, N. M. & Murray, K. E. High-power thulium fiber laser ablation of urinary tissues at 1.94 microm. J Endourol 19, 25\u201331 (2005).","journal-title":"J Endourol"},{"key":"BFsrep14542_CR32","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1089\/end.2013.0404","volume":"28","author":"K Tang","year":"2014","unstructured":"Tang, K. et al. Early outcomes of Thulium laser versus transurethral resection of the prostate for managing benign prostatic hyperplasia: a systematic review and meta-analysis of comparative studies. J Endourol 28, 65\u201372 (2014).","journal-title":"J Endourol"},{"key":"BFsrep14542_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","volume":"17","author":"AR Jadad","year":"1996","unstructured":"Jadad, A. R. et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17, 1\u201312 (1996).","journal-title":"Control Clin Trials"},{"key":"BFsrep14542_CR34","unstructured":"Wells, G. A. et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analysis. Ottawa Health Research Institute Web site. http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.htm. Accessed: June 15, 2012."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep14542","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep14542.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep14542.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:44:20Z","timestamp":1672962260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep14542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,7]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,11,26]]}},"alternative-id":["BFsrep14542"],"URL":"https:\/\/doi.org\/10.1038\/srep14542","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,7]]},"assertion":[{"value":"21 October 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14542"}}