{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T04:38:48Z","timestamp":1767155928169,"version":"build-2238731810"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T00:00:00Z","timestamp":1444608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T00:00:00Z","timestamp":1444608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Migraine headache is often timed with the menstrual cycle. Some studies have reported reduced risk of breast cancer in migraineurs but most of those did not distinguish menstrually-related from non-menstrually-related migraine. To examine the possible associations between breast cancer and migraine overall and between cancer subcategories and the two migraine subtypes, we used a cohort study of 50,884 women whose sister had breast cancer and a sister-matched case-control study including 1,418 young-onset (&lt;50 years) breast cancer cases. We analyzed the two studies individually and also in tandem via a hybrid Cox model, examining subcategories of breast cancer in relation to menstrually-related and non-menstrually-related migraine. History of migraine was not associated with breast cancer overall. Migraine showed an inverse association with ductal carcinoma\n                    <jats:italic>in situ<\/jats:italic>\n                    (HR\u2009=\u20090.77; 95% CI (0.62,0.96)). Also, women with non-menstrually-related migraine had increased risk (HR\u2009=\u20091.30, 95% CI (0.93,1.81)) while women with menstrually-related migraine had decreased risk (HR\u2009=\u20090.63, 95% CI (0.42,0.96)) of hormone-receptor-negative (ER\u2212\/PR\u2212) cancer, with a significant contrast in estimated effects (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.005). While replication of these subset-based findings will be needed, effect specificity could suggest that while migraine has little overall association with breast cancer, menstrual migraine may be associated with reduced risk of ER\u2212\/PR\u2212 breast cancer.\n                  <\/jats:p>","DOI":"10.1038\/srep14943","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T06:43:48Z","timestamp":1444632228000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Migraine and possible etiologic heterogeneity for hormone-receptor-negative breast cancer"],"prefix":"10.1038","volume":"5","author":[{"given":"Min","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A.","family":"DeRoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale P.","family":"Sandler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarice R.","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,10,12]]},"reference":[{"key":"BFsrep14943_CR1","first-page":"S17","volume":"44","author":"WF Stewart","year":"1994","unstructured":"Stewart, W. F., Shechter, A. & Rasmussen, B. K. Migraine prevalence. A review of population-based studies. Neurology 44, S17\u201323 (1994).","journal-title":"Neurology"},{"key":"BFsrep14943_CR2","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1111\/j.1468-2982.2008.01666.x","volume":"28","author":"WF Stewart","year":"2008","unstructured":"Stewart, W. F., Wood, C., Reed, M. L., Roy, J. & Lipton, R. B. Cumulative lifetime migraine incidence in women and men. Cephalalgia : an international journal of headache 28, 1170\u20131178 (2008).","journal-title":"Cephalalgia : an international journal of headache"},{"key":"BFsrep14943_CR3","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3109\/03014460.2012.700069","volume":"39","author":"A Reza","year":"2012","unstructured":"Reza, A., Sievert, L. L., Rahberg, N., Morrison, L. A. & Brown, D. E. Prevalence and determinants of headaches in Hawaii: the Hilo Women\u2019s Health Study. Annals of human biology 39, 305\u2013314 (2012).","journal-title":"Annals of human biology"},{"key":"BFsrep14943_CR4","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1783\/147118907779399684","volume":"33","author":"EA Macgregor","year":"2007","unstructured":"Macgregor, E. A. Menstrual migraine: a clinical review. The journal of family planning and reproductive health care \/ Faculty of Family Planning & Reproductive Health Care, Royal College of Obstetricians & Gynaecologists 33, 36\u201347 (2007).","journal-title":"The journal of family planning and reproductive health care \/ Faculty of Family Planning & Reproductive Health Care, Royal College of Obstetricians & Gynaecologists"},{"key":"BFsrep14943_CR5","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1212\/01.wnl.0000310638.54698.36","volume":"70","author":"T Pringsheim","year":"2008","unstructured":"Pringsheim, T., Davenport, W. J. & Dodick, D. Acute treatment and prevention of menstrually related migraine headache: evidence-based review. Neurology 70, 1555\u20131563 (2008).","journal-title":"Neurology"},{"key":"BFsrep14943_CR6","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1212\/01.wnl.0000249114.52802.55","volume":"67","author":"EA MacGregor","year":"2006","unstructured":"MacGregor, E. A., Frith, A., Ellis, J., Aspinall, L. & Hackshaw, A. Prevention of menstrual attacks of migraine: a double-blind placebo-controlled crossover study. Neurology 67, 2159\u20132163 (2006).","journal-title":"Neurology"},{"key":"BFsrep14943_CR7","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s10549-013-2721-9","volume":"142","author":"ET Warner","year":"2013","unstructured":"Warner, E. T. et al. Reproductive factors and risk of premenopausal breast cancer by age at diagnosis: are there differences before and after age 40? Breast cancer research and treatment 142, 165\u2013175 (2013).","journal-title":"Breast cancer research and treatment"},{"key":"BFsrep14943_CR8","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1093\/oxfordjournals.aje.a117079","volume":"139","author":"B Rosner","year":"1994","unstructured":"Rosner, B., Colditz, G. A. & Willett, W. C. Reproductive risk factors in a prospective study of breast cancer: the Nurses\u2019 Health Study. Am J Epidemiol 139, 819\u2013835 (1994).","journal-title":"Am J Epidemiol"},{"key":"BFsrep14943_CR9","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S0140-6736(03)14596-5","volume":"362","author":"V Beral","year":"2003","unstructured":"Beral, V. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 362, 419\u2013427 (2003).","journal-title":"Lancet"},{"key":"BFsrep14943_CR10","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1001\/jama.288.3.321","volume":"288","author":"JE Rossouw","year":"2002","unstructured":"Rossouw, J. E. et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women\u2019s Health Initiative randomized controlled trial. JAMA 288, 321\u2013333 (2002).","journal-title":"JAMA"},{"key":"BFsrep14943_CR11","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1158\/1055-9965.EPI-09-0532","volume":"19","author":"L Baglietto","year":"2010","unstructured":"Baglietto, L. et al. Circulating steroid hormone levels and risk of breast cancer for postmenopausal women. Cancer Epidemiol Biomarkers Prev 19, 492\u2013502 (2010).","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BFsrep14943_CR12","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1158\/1055-9965.EPI-08-0808","volume":"18","author":"S Sieri","year":"2009","unstructured":"Sieri, S. et al. Sex hormone levels, breast cancer risk and cancer receptor status in postmenopausal women: the ORDET cohort. Cancer Epidemiol Biomarkers Prev 18, 169\u2013176 (2009).","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BFsrep14943_CR13","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1093\/jnci\/94.8.606","volume":"94","author":"T Key","year":"2002","unstructured":"Key, T. et al. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 94, 606\u2013616 (2002).","journal-title":"J Natl Cancer Inst"},{"key":"BFsrep14943_CR14","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s10549-012-2391-z","volume":"137","author":"X Zhang","year":"2013","unstructured":"Zhang, X., Tworoger, S. S., Eliassen, A. H. & Hankinson, S. E. Postmenopausal plasma sex hormone levels and breast cancer risk over 20 years of follow-up. Breast cancer research and treatment 137, 883\u2013892 (2013).","journal-title":"Breast cancer research and treatment"},{"key":"BFsrep14943_CR15","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1158\/1078-0432.CCR-06-1109","volume":"13","author":"LA Carey","year":"2007","unstructured":"Carey, L. A. et al. The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res 13, 2329\u20132334 (2007).","journal-title":"Clin Cancer Res"},{"key":"BFsrep14943_CR16","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1200\/JCO.2009.25.0423","volume":"28","author":"CI Li","year":"2010","unstructured":"Li, C. I. et al. Migraine history and breast cancer risk among postmenopausal women. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 28, 1005\u20131010 (2010).","journal-title":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology"},{"key":"BFsrep14943_CR17","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1158\/1055-9965.EPI-09-0291","volume":"18","author":"CI Li","year":"2009","unstructured":"Li, C. I. et al. Relationship between migraine history and breast cancer risk among premenopausal and postmenopausal women. Cancer Epidemiol Biomarkers Prev 18, 2030\u20132034 (2009).","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BFsrep14943_CR18","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.1158\/1055-9965.EPI-08-0527","volume":"17","author":"RW Mathes","year":"2008","unstructured":"Mathes, R. W. et al. Migraine in postmenopausal women and the risk of invasive breast cancer. Cancer Epidemiol Biomarkers Prev 17, 3116\u20133122 (2008).","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BFsrep14943_CR19","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s10552-012-0092-x","volume":"24","author":"AC Winter","year":"2013","unstructured":"Winter, A. C. et al. Migraine and subsequent risk of breast cancer: a prospective cohort study. Cancer Causes Control 24, 81\u201389 (2013).","journal-title":"Cancer Causes Control"},{"key":"BFsrep14943_CR20","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1093\/aje\/kwm097","volume":"166","author":"CR Weinberg","year":"2007","unstructured":"Weinberg, C. R., Shore, D. L., Umbach, D. M. & Sandler, D. P. Using risk-based sampling to enrich cohorts for endpoints, genes and exposures. Am J Epidemiol 166, 447\u2013455 (2007).","journal-title":"Am J Epidemiol"},{"key":"BFsrep14943_CR21","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1093\/jnci\/djs255","volume":"104","author":"C Fei","year":"2012","unstructured":"Fei, C., Deroo, L. A., Sandler, D. P. & Weinberg, C. R. Fertility drugs and young-onset breast cancer: results from the Two Sister Study. J Natl Cancer Inst 104, 1021\u20131027 (2012).","journal-title":"J Natl Cancer Inst"},{"key":"BFsrep14943_CR22","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1097\/00001648-199901000-00008","volume":"10","author":"S Greenland","year":"1999","unstructured":"Greenland, S., Pearl, J. & Robins, J. M. Causal diagrams for epidemiologic research. Epidemiology 10, 37\u201348 (1999).","journal-title":"Epidemiology"},{"key":"BFsrep14943_CR23","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/sim.4780130206","volume":"13","author":"WW Piegorsch","year":"1994","unstructured":"Piegorsch, W. W., Weinberg, C. R. & Taylor, J. A. Non-hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies. Stat Med 13, 153\u2013162 (1994).","journal-title":"Stat Med"},{"key":"BFsrep14943_CR24","first-page":"173","volume":"3","author":"CB Begg","year":"1994","unstructured":"Begg, C. B. & Zhang, Z. F. Statistical analysis of molecular epidemiology studies employing case-series. Cancer Epidemiol Biomarkers Prev 3, 173\u2013175 (1994).","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BFsrep14943_CR25","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1001\/jama.295.15.1824","volume":"295","author":"JL Brandes","year":"2006","unstructured":"Brandes, J. L. The influence of estrogen on migraine: a systematic review. JAMA 295, 1824\u20131830 (2006).","journal-title":"JAMA"},{"key":"BFsrep14943_CR26","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1007\/s10552-014-0479-y","volume":"25","author":"SJ Lowry","year":"2014","unstructured":"Lowry, S. J., Malone, K. E., Cushing-Haugen, K. L. & Li, C. I. The risk of breast cancer associated with specific patterns of migraine history. Cancer causes & control : CCC 25, 1707\u20131715 (2014).","journal-title":"Cancer causes & control : CCC"},{"key":"BFsrep14943_CR27","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1093\/jnci\/dju381","volume":"107","author":"AC Winter","year":"2015","unstructured":"Winter, A. C. et al. Migraine and breast cancer risk: a prospective cohort study and meta-analysis. J Natl Cancer Inst 107, 381 (2015).","journal-title":"J Natl Cancer Inst"},{"key":"BFsrep14943_CR28","unstructured":"The International Classification of Headache Disorders: 2nd edition. Cephalalgia : an international journal of headache 24 Suppl 1, 9\u2013160 (2004)."}],"updated-by":[{"DOI":"10.1038\/srep17238","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T00:00:00Z","timestamp":1452124800000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep14943.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep14943","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep14943.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T10:49:24Z","timestamp":1672915764000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep14943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,12]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12,7]]}},"alternative-id":["BFsrep14943"],"URL":"https:\/\/doi.org\/10.1038\/srep14943","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,12]]},"assertion":[{"value":"11 March 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2016","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14943"}}