{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:38:42Z","timestamp":1790761122910,"version":"4.1.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a debate on whether invertebrates possess an antiviral immunity similar to the interferon (IFN) system of vertebrates. The Vago gene from arthropods encodes a viral-activated secreted peptide that restricts virus infection through activating the JAK-STAT pathway and is considered to be a cytokine functionally similar to IFN. In this study, the first crustacean IFN regulatory factor (IRF)-like gene was identified in Pacific white shrimp, <jats:italic>Litopenaeus vannamei<\/jats:italic>. The <jats:italic>L. vannamei<\/jats:italic> IRF showed similar protein nature to mammalian IRFs and could be activated during virus infection. As a transcriptional regulatory factor, <jats:italic>L. vannamei<\/jats:italic> IRF could activate the IFN-stimulated response element (ISRE)-containing promoter to regulate the expression of mammalian type I IFNs and initiate an antiviral state in mammalian cells. More importantly, IRF could bind the 5\u2032-untranslated region of <jats:italic>L. vannamei<\/jats:italic> Vago4 gene and activate its transcription, suggesting that shrimp Vago may be induced in a similar manner to that of IFNs and supporting the opinion that Vago might function as an IFN-like molecule in invertebrates. These suggested that shrimp might possess an IRF-Vago-JAK\/STAT regulatory axis, which is similar to the IRF-IFN-JAK\/STAT axis of vertebrates, indicating that invertebrates might possess an IFN system-like antiviral mechanism.<\/jats:p>","DOI":"10.1038\/srep15078","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T09:25:21Z","timestamp":1444728321000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Activation of Vago by interferon regulatory factor (IRF) suggests an interferon system-like antiviral mechanism in shrimp"],"prefix":"10.1038","volume":"5","author":[{"given":"Chaozheng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Ping","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,13]]},"reference":[{"key":"BFsrep15078_CR1","first-page":"131","volume":"40","author":"G Premecz","year":"1993","unstructured":"Premecz, G., Markovits, A. & Foldes, I. Signal transducing mechanisms in interferon action (a brief review). Acta Microbiol Hung 40, 131\u201340 (1993).","journal-title":"Acta Microbiol Hung"},{"key":"BFsrep15078_CR2","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/00004424-198703000-00017","volume":"22","author":"GJ Stanton","year":"1987","unstructured":"Stanton, G. J., Weigent, D. A., Fleischmann, W. J., Dianzani, F. & Baron S. Interferon review. Invest Radiol 22, 259\u201373 (1987).","journal-title":"Invest Radiol"},{"key":"BFsrep15078_CR3","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.coviro.2011.11.001","volume":"1","author":"DE Levy","year":"2011","unstructured":"Levy, D. E., Marie, I. J. & Durbin, J. E. Induction and function of type I and III interferon in response to viral infection. Curr Opin Virol 1, 476\u201386 (2011).","journal-title":"Curr Opin Virol"},{"key":"BFsrep15078_CR4","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/1743-422X-10-224","volume":"10","author":"E Voigt","year":"2013","unstructured":"Voigt, E., Inankur, B., Baltes, A. & Yin, J. A quantitative infection assay for human type I, II and III interferon antiviral activities. Virol J 10, 224 (2013).","journal-title":"Virol J"},{"key":"BFsrep15078_CR5","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1089\/jir.2014.0066","volume":"34","author":"E Reid","year":"2014","unstructured":"Reid, E. & Charleston, B. Type I and III Interferon Production in Response to RNA Viruses. J Interferon Cytokine Res 34, 649\u201358 (2014).","journal-title":"J Interferon Cytokine Res"},{"key":"BFsrep15078_CR6","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1002\/hep.26959","volume":"59","author":"D Olagnier","year":"2014","unstructured":"Olagnier, D. & Hiscott, J. Type I and type III interferon-induced immune response: it\u2019s a matter of kinetics and magnitude. Hepatology 59, 1225\u20138 (2014).","journal-title":"Hepatology"},{"key":"BFsrep15078_CR7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1089\/107999002753452665","volume":"22","author":"B Barnes","year":"2002","unstructured":"Barnes, B., Lubyova, B. & Pitha, P. M. On the role of IRF in host defense. J Interferon Cytokine Res 22, 59\u201371 (2002).","journal-title":"J Interferon Cytokine Res"},{"key":"BFsrep15078_CR8","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1101\/sqb.2013.78.020321","volume":"78","author":"H Ikushima","year":"2013","unstructured":"Ikushima, H., Negishi, H. & Taniguchi, T. The IRF family transcription factors at the interface of innate and adaptive immune responses. Cold Spring Harb Symp Quant Biol 78, 105\u201316 (2013).","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"BFsrep15078_CR9","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.4161\/onci.22475","volume":"1","author":"H Yanai","year":"2012","unstructured":"Yanai, H., Negishi, H. & Taniguchi, T. The IRF family of transcription factors: Inception, impact and implications in oncogenesis. Oncoimmunology 1, 1376\u20131386 (2012).","journal-title":"Oncoimmunology"},{"key":"BFsrep15078_CR10","doi-asserted-by":"publisher","first-page":"9785","DOI":"10.1074\/jbc.272.15.9785","volume":"272","author":"R Sharf","year":"1997","unstructured":"Sharf, R. et al. Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA. J Biol Chem 272, 9785\u201392 (1997).","journal-title":"J Biol Chem"},{"key":"BFsrep15078_CR11","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.cellsig.2009.12.005","volume":"22","author":"W Chen","year":"2010","unstructured":"Chen, W. & Royer, W. J. Structural insights into interferon regulatory factor activation. Cell Signal 22, 883\u20137 (2010).","journal-title":"Cell Signal"},{"key":"BFsrep15078_CR12","unstructured":"Ysebrant, D. L. L., Martinet, V. & Goriely, S. Interferon regulatory factor 3 in adaptive immune responses. Cell Mol Life Sci (2014)."},{"key":"BFsrep15078_CR13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1089\/107999002753452700","volume":"22","author":"L Zhang","year":"2002","unstructured":"Zhang, L. & Pagano, J. S. Structure and function of IRF-7. J Interferon Cytokine Res 22, 95\u2013101 (2002).","journal-title":"J Interferon Cytokine Res"},{"key":"BFsrep15078_CR14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.4161\/rna.27717","volume":"11","author":"D Luo","year":"2014","unstructured":"Luo, D. Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors. RNA Biol 11, 25\u201332 (2014).","journal-title":"RNA Biol"},{"key":"BFsrep15078_CR15","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.mib.2014.05.011","volume":"20C","author":"JS Yoo","year":"2014","unstructured":"Yoo, J. S., Kato, H. & Fujita, T. Sensing viral invasion by RIG-I like receptors. Curr Opin Microbiol 20C, 131\u2013138 (2014).","journal-title":"Curr Opin Microbiol"},{"key":"BFsrep15078_CR16","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nri3446","volume":"13","author":"LA O\u2019Neill","year":"2013","unstructured":"O\u2019Neill, L. A., Golenbock, D. & Bowie, A. G. The history of Toll-like receptors - redefining innate immunity. Nat Rev Immunol 13, 453\u201360 (2013).","journal-title":"Nat Rev Immunol"},{"key":"BFsrep15078_CR17","doi-asserted-by":"publisher","first-page":"13534","DOI":"10.1074\/jbc.M113.457218","volume":"288","author":"W Zhang","year":"2013","unstructured":"Zhang, W. et al. DNA-dependent activator of interferon-regulatory factors (DAI) promotes lupus nephritis by activating the calcium pathway. J Biol Chem 288, 13534\u201350 (2013).","journal-title":"J Biol Chem"},{"key":"BFsrep15078_CR18","doi-asserted-by":"publisher","first-page":"4417","DOI":"10.1128\/JVI.03282-12","volume":"87","author":"VV Singh","year":"2013","unstructured":"Singh, V. V. et al. Kaposi\u2019s sarcoma-associated herpesvirus latency in endothelial and B cells activates gamma interferon-inducible protein 16-mediated inflammasomes. J Virol 87, 4417\u201331 (2013).","journal-title":"J Virol"},{"key":"BFsrep15078_CR19","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/ni.1876","volume":"11","author":"P Yang","year":"2010","unstructured":"Yang, P. et al. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol 11, 487\u201394 (2010).","journal-title":"Nat Immunol"},{"key":"BFsrep15078_CR20","doi-asserted-by":"publisher","first-page":"3451","DOI":"10.1038\/sj.emboj.7601773","volume":"26","author":"F Ikeda","year":"2007","unstructured":"Ikeda, F. et al. Involvement of the ubiquitin-like domain of TBK1\/IKK-i kinases in regulation of IFN-inducible genes. EMBO J 26, 3451\u201362 (2007).","journal-title":"EMBO J"},{"key":"BFsrep15078_CR21","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1126\/science.1081315","volume":"300","author":"S Sharma","year":"2003","unstructured":"Sharma, S. et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 300, 1148\u201351 (2003).","journal-title":"Science"},{"key":"BFsrep15078_CR22","doi-asserted-by":"publisher","first-page":"17671","DOI":"10.1074\/jbc.M411389200","volume":"280","author":"A Caillaud","year":"2005","unstructured":"Caillaud, A., Hovanessian, A. G., Levy, D. E. & Marie, I. J. Regulatory serine residues mediate phosphorylation-dependent and phosphorylation-independent activation of interferon regulatory factor 7. J Biol Chem 280, 17671\u20137 (2005).","journal-title":"J Biol Chem"},{"key":"BFsrep15078_CR23","first-page":"17","volume":"52","author":"S Paz","year":"2006","unstructured":"Paz, S. et al. Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway. Cell Mol Biol (Noisy-le-grand) 52, 17\u201328 (2006).","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"BFsrep15078_CR24","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.dci.2012.06.003","volume":"38","author":"YB Zhang","year":"2012","unstructured":"Zhang, Y. B. & Gui, J. F. Molecular regulation of interferon antiviral response in fish. Dev Comp Immunol 38, 193\u2013202 (2012).","journal-title":"Dev Comp Immunol"},{"key":"BFsrep15078_CR25","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nri3581","volume":"14","author":"LB Ivashkiv","year":"2014","unstructured":"Ivashkiv, L. B. & Donlin, L. T. Regulation of type I interferon responses. Nat Rev Immunol 14, 36\u201349 (2014).","journal-title":"Nat Rev Immunol"},{"key":"BFsrep15078_CR26","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1016\/j.dci.2011.07.001","volume":"35","author":"J Zou","year":"2011","unstructured":"Zou, J. & Secombes, C. J. Teleost fish interferons and their role in immunity. Dev Comp Immunol 35, 1376\u201387 (2011).","journal-title":"Dev Comp Immunol"},{"key":"BFsrep15078_CR27","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.dci.2013.08.017","volume":"43","author":"B Collet","year":"2014","unstructured":"Collet, B. Innate immune responses of salmonid fish to viral infections. Dev Comp Immunol 43, 160\u201373 (2014).","journal-title":"Dev Comp Immunol"},{"key":"BFsrep15078_CR28","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1007\/s11427-015-4802-y","volume":"58","author":"Q Zhang","year":"2015","unstructured":"Zhang, Q. & Gui, J. F. Virus genomes and virus-host interactions in aquaculture animals. Sci China Life Sci 58, 156\u201369 (2015).","journal-title":"Sci China Life Sci"},{"key":"BFsrep15078_CR29","doi-asserted-by":"publisher","first-page":"7573","DOI":"10.4049\/jimmunol.1002401","volume":"185","author":"F Sun","year":"2010","unstructured":"Sun, F. et al. Characterization of fish IRF3 as an IFN-inducible protein reveals evolving regulation of IFN response in vertebrates. J Immunol 185, 7573\u201382 (2010).","journal-title":"J Immunol"},{"key":"BFsrep15078_CR30","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.4049\/jimmunol.1100642","volume":"187","author":"F Sun","year":"2011","unstructured":"Sun, F. et al. Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7. J Immunol 187, 2531\u20139 (2011).","journal-title":"J Immunol"},{"key":"BFsrep15078_CR31","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.4049\/jimmunol.1402415","volume":"194","author":"H Feng","year":"2015","unstructured":"Feng, H. et al. Zebrafish IRF1 regulates IFN antiviral response through binding to IFNvarphi1 and IFNvarphi3 promoters downstream of MyD88 signaling. J Immunol 194, 1225\u201338 (2015).","journal-title":"J Immunol"},{"key":"BFsrep15078_CR32","unstructured":"Wang, P. H., Weng, S. P. & He, J. G. Nucleic acid-induced antiviral immunity in invertebrates: An evolutionary perspective. Dev Comp Immunol (2014)."},{"key":"BFsrep15078_CR33","doi-asserted-by":"publisher","first-page":"10442","DOI":"10.1128\/JVI.78.19.10442-10448.2004","volume":"78","author":"J Robalino","year":"2004","unstructured":"Robalino, J. et al. Induction of antiviral immunity by double-stranded RNA in a marine invertebrate. J Virol 78, 10442\u20138 (2004).","journal-title":"J Virol"},{"key":"BFsrep15078_CR34","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.fsi.2013.04.051","volume":"35","author":"TJ Green","year":"2013","unstructured":"Green, T. J. & Montagnani, C. Poly I:C induces a protective antiviral immune response in the Pacific oyster (Crassostrea gigas) against subsequent challenge with Ostreid herpesvirus (OsHV-1 muvar). Fish Shellfish Immunol 35, 382\u20138 (2013).","journal-title":"Fish Shellfish Immunol"},{"key":"BFsrep15078_CR35","doi-asserted-by":"publisher","first-page":"13561","DOI":"10.1128\/JVI.79.21.13561-13571.2005","volume":"79","author":"J Robalino","year":"2005","unstructured":"Robalino, J. et al. Double-stranded RNA induces sequence-specific antiviral silencing in addition to nonspecific immunity in a marine shrimp: convergence of RNA interference and innate immunity in the invertebrate antiviral response? J Virol 79, 13561\u201371 (2005).","journal-title":"J Virol"},{"key":"BFsrep15078_CR36","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1016\/S0960-9822(01)00524-3","volume":"11","author":"S Brown","year":"2001","unstructured":"Brown, S., Hu, N. & Hombria, J. C. Identification of the first invertebrate interleukin JAK\/STAT receptor, the Drosophila gene domeless. Curr Biol 11, 1700\u20135 (2001).","journal-title":"Curr Biol"},{"key":"BFsrep15078_CR37","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.fsi.2010.01.022","volume":"28","author":"CH Cheng","year":"2010","unstructured":"Cheng, C. H. et al. Expression and characterization of the JAK kinase and STAT protein from brine shrimp, Artemia franciscana. Fish Shellfish Immunol 28, 774\u201382 (2010).","journal-title":"Fish Shellfish Immunol"},{"key":"BFsrep15078_CR38","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.fsi.2006.09.007","volume":"23","author":"M De Zoysa","year":"2007","unstructured":"De Zoysa, M. et al. First report of invertebrate Mx: cloning, characterization and expression analysis of Mx cDNA in disk abalone (Haliotis discus discus). Fish Shellfish Immunol 23, 86\u201396 (2007).","journal-title":"Fish Shellfish Immunol"},{"key":"BFsrep15078_CR39","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.fsi.2014.07.029","volume":"40","author":"Y Zhang","year":"2014","unstructured":"Zhang, Y. et al. The first invertebrate RIG-I-like receptor (RLR) homolog gene in the pacific oyster Crassostrea gigas. Fish Shellfish Immunol 40, 466\u201371 (2014).","journal-title":"Fish Shellfish Immunol"},{"key":"BFsrep15078_CR40","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1093\/molbev\/msp167","volume":"26","author":"J Nehyba","year":"2009","unstructured":"Nehyba, J., Hrdlickova, R. & Bose, H. R. Dynamic evolution of immune system regulators: the history of the interferon regulatory factor family. Mol Biol Evol 26, 2539\u201350 (2009).","journal-title":"Mol Biol Evol"},{"key":"BFsrep15078_CR41","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/j.fsi.2013.02.003","volume":"34","author":"XD Huang","year":"2013","unstructured":"Huang, X. D. et al. Molecular characterization of interferon regulatory factor 2 (IRF-2) homolog in pearl oyster Pinctada fucata. Fish Shellfish Immunol 34, 1279\u201386 (2013).","journal-title":"Fish Shellfish Immunol"},{"key":"BFsrep15078_CR42","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.ydbio.2007.05.022","volume":"308","author":"K Azumi","year":"2007","unstructured":"Azumi, K. et al. Gene expression profile during the life cycle of the urochordate Ciona intestinalis. Dev Biol 308, 572\u201382 (2007).","journal-title":"Dev Biol"},{"key":"BFsrep15078_CR43","doi-asserted-by":"publisher","first-page":"18915","DOI":"10.1073\/pnas.1205231109","volume":"109","author":"PN Paradkar","year":"2012","unstructured":"Paradkar, P. N., Trinidad, L., Voysey, R., Duchemin, J. B. & Walker, P. J. Secreted Vago restricts West Nile virus infection in Culex mosquito cells by activating the Jak-STAT pathway. Proc Natl Acad Sci USA 109, 18915\u201320 (2012).","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFsrep15078_CR44","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1038\/ni.1664","volume":"9","author":"S Deddouche","year":"2008","unstructured":"Deddouche, S. et al. The DExD\/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila. Nat Immunol 9, 1425\u201332 (2008).","journal-title":"Nat Immunol"},{"key":"BFsrep15078_CR45","doi-asserted-by":"publisher","first-page":"e2823","DOI":"10.1371\/journal.pntd.0002823","volume":"8","author":"PN Paradkar","year":"2014","unstructured":"Paradkar, P. N., Duchemin, J. B., Voysey, R. & Walker, P. J. Dicer-2-dependent activation of Culex Vago occurs via the TRAF-Rel2 signaling pathway. PLoS Negl Trop Dis 8, e2823 (2014).","journal-title":"PLoS Negl Trop Dis"},{"key":"BFsrep15078_CR46","doi-asserted-by":"crossref","first-page":"21404","DOI":"10.1016\/S0021-9258(18)54652-4","volume":"266","author":"M Nakayama","year":"1991","unstructured":"Nakayama, M., Nagata, K., Kato, A. & Ishihama, A. Interferon-inducible mouse Mx1 protein that confers resistance to influenza virus is GTPase. J Biol Chem 266, 21404\u20138 (1991).","journal-title":"J Biol Chem"},{"key":"BFsrep15078_CR47","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.virusres.2009.04.016","volume":"144","author":"Y Luo","year":"2009","unstructured":"Luo, Y. et al. Tiger frog virus can infect zebrafish cells for studying up- or down-regulated genes by proteomics approach. Virus Res 144, 171\u20139 (2009).","journal-title":"Virus Res"},{"key":"BFsrep15078_CR48","doi-asserted-by":"publisher","first-page":"6416","DOI":"10.1128\/JVI.01500-10","volume":"85","author":"CJ Guo","year":"2011","unstructured":"Guo, C. J. et al. Entry of tiger frog virus (an Iridovirus) into HepG2 cells via a pH-dependent, atypical, caveola-mediated endocytosis pathway. J Virol 85, 6416\u201326 (2011).","journal-title":"J Virol"},{"key":"BFsrep15078_CR49","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.dci.2011.01.010","volume":"35","author":"YH Chen","year":"2011","unstructured":"Chen, Y. H. et al. Identification and functional characterization of Dicer2 and five single VWC domain proteins of Litopenaeus vannamei. Dev Comp Immunol 35, 661\u201371 (2011).","journal-title":"Dev Comp Immunol"},{"key":"BFsrep15078_CR50","doi-asserted-by":"publisher","first-page":"7576","DOI":"10.1074\/jbc.M608618200","volume":"282","author":"K Onoguchi","year":"2007","unstructured":"Onoguchi, K. et al. Viral infections activate types I and III interferon genes through a common mechanism. J Biol Chem 282, 7576\u201381 (2007).","journal-title":"J Biol Chem"},{"key":"BFsrep15078_CR51","doi-asserted-by":"publisher","first-page":"3434","DOI":"10.4049\/jimmunol.179.6.3434","volume":"179","author":"PI Osterlund","year":"2007","unstructured":"Osterlund, P. I., Pietila, T. E., Veckman, V., Kotenko, S. V. & Julkunen, I. IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes. J Immunol 179, 3434\u201342 (2007).","journal-title":"J Immunol"},{"key":"BFsrep15078_CR52","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1089\/jir.2010.0117","volume":"30","author":"K Onomoto","year":"2010","unstructured":"Onomoto, K., Onoguchi, K., Takahasi, K. & Fujita, T. Type I interferon production induced by RIG-I-like receptors. J Interferon Cytokine Res 30, 875\u201381 (2010).","journal-title":"J Interferon Cytokine Res"},{"key":"BFsrep15078_CR53","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.antiviral.2013.05.016","volume":"99","author":"PH Wang","year":"2013","unstructured":"Wang, P. H. et al. Nucleic acid-induced antiviral immunity in shrimp. Antiviral Res 99, 270\u201380 (2013).","journal-title":"Antiviral Res"},{"key":"BFsrep15078_CR54","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.dci.2013.10.005","volume":"43","author":"R Sun","year":"2014","unstructured":"Sun, R. et al. The immune responses triggered by CpG ODNs in shrimp Litopenaeus vannamei are associated with LvTolls. Dev Comp Immunol 43, 15\u201322 (2014).","journal-title":"Dev Comp Immunol"},{"key":"BFsrep15078_CR55","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.dci.2013.08.012","volume":"42","author":"C Li","year":"2014","unstructured":"Li, C. et al. Presence of Tube isoforms in Litopenaeus vannamei suggests various regulatory patterns of signal transduction in invertebrate NF-kappaB pathway. Dev Comp Immunol 42, 174\u201385 (2014).","journal-title":"Dev Comp Immunol"},{"key":"BFsrep15078_CR56","doi-asserted-by":"publisher","first-page":"e47442","DOI":"10.1371\/journal.pone.0047442","volume":"7","author":"C Li","year":"2012","unstructured":"Li, C. et al. Analysis of Litopenaeus vannamei transcriptome using the next-generation DNA sequencing technique. PLoS One 7, e47442 (2012).","journal-title":"PLoS One"},{"key":"BFsrep15078_CR57","doi-asserted-by":"publisher","first-page":"e49711","DOI":"10.1371\/journal.pone.0049711","volume":"7","author":"C Li","year":"2012","unstructured":"Li, C. et al. Identification, characterization and function analysis of the Cactus gene from Litopenaeus vannamei. PLoS One 7, e49711 (2012).","journal-title":"PLoS One"},{"key":"BFsrep15078_CR58","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.fsi.2010.04.020","volume":"29","author":"Z Li","year":"2010","unstructured":"Li, Z. et al. Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish Shellfish Immunol 29, 399\u2013406 (2010).","journal-title":"Fish Shellfish Immunol"},{"key":"BFsrep15078_CR59","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.dci.2014.01.012","volume":"44","author":"C Li","year":"2014","unstructured":"Li, C. et al. Pellino protein from pacific white shrimp Litopenaeus vannamei positively regulates NF-kappaB activation. Dev Comp Immunol 44, 341\u201350 (2014).","journal-title":"Dev Comp Immunol"},{"key":"BFsrep15078_CR60","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/eji.201242806","volume":"43","author":"T Huang","year":"2013","unstructured":"Huang, T. & Zhang, X. Host defense against DNA virus infection in shrimp is mediated by the siRNA pathway. Eur J Immunol 43, 137\u201346 (2013).","journal-title":"Eur J Immunol"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep15078.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep15078","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep15078.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T15:39:08Z","timestamp":1672933148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep15078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,13]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12,7]]}},"alternative-id":["BFsrep15078"],"URL":"https:\/\/doi.org\/10.1038\/srep15078","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,13]]},"assertion":[{"value":"26 June 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15078"}}