{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:36:45Z","timestamp":1791221805215,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T00:00:00Z","timestamp":1444780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T00:00:00Z","timestamp":1444780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Long-term consumption of red meat has been considered a potential risk to gut health, but this is based on clinic investigations, excessive intake of fat, heme and some injurious compounds formed during cooking or additions to processed meat products. Whether intake of red meat protein affects gut bacteria and the health of the host remains unclear. In this work, we compared the composition of gut bacteria in the caecum, by sequencing the V4-V5 region of 16S ribosomal RNA gene, obtained from rats fed with proteins from red meat (beef and pork), white meat (chicken and fish) and other sources (casein and soy). The results showed significant differences in profiles of gut bacteria between the six diet groups. Rats fed with meat proteins had a similar overall structure of caecal bacterial communities separated from those fed non-meat proteins. The beneficial genus <jats:italic>Lactobacillus<\/jats:italic> was higher in the white meat than in the red meat or non-meat protein groups. Also, rats fed with meat proteins and casein had significantly lower levels of lipopolysaccharide-binding proteins, suggesting that the intake of meat proteins may maintain a more balanced composition of gut bacteria, thereby reducing the antigen load and inflammatory response in the host.<\/jats:p>","DOI":"10.1038\/srep15220","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T09:24:00Z","timestamp":1444814640000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":149,"title":["Meat, dairy and plant proteins alter bacterial composition of rat gut bacteria"],"prefix":"10.1038","volume":"5","author":[{"given":"Yingying","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xisha","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,14]]},"reference":[{"key":"BFsrep15220_CR1","doi-asserted-by":"crossref","unstructured":"Bastide, N. et al. A central role for heme iron in colon carcinogenesis associated with red meat intake. Cancer Res. dio: 10.1158\/0008-5472.CAN-14-2554 (2015).","DOI":"10.1158\/0008-5472.CAN-14-2554"},{"key":"BFsrep15220_CR2","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/j.jada.2011.05.002","volume":"111","author":"D Bujnowski","year":"2011","unstructured":"Bujnowski, D. et al. Longitudinal association between animal and vegetable protein intake and obesity among men in the United States: the Chicago Western Electric Study. J. Am. Diet. Assoc. 111, 1150\u20131155 e1 (2011).","journal-title":"J. Am. Diet. Assoc."},{"key":"BFsrep15220_CR3","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.meatsci.2011.04.009","volume":"89","author":"DE Corpet","year":"2011","unstructured":"Corpet, D. E. Red meat and colon cancer: Should we become vegetarians, or can we make meat safer? Meat Sci. 89, 310\u2013316 (2011).","journal-title":"Meat Sci."},{"key":"BFsrep15220_CR4","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1093\/jjco\/hyu061","volume":"44","author":"NM Pham","year":"2014","unstructured":"Pham, N. M. et al. Meat consumption and colorectal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn. J. Clin. Oncol. 44, 641\u2013650 (2014).","journal-title":"Jpn. J. Clin. Oncol."},{"key":"BFsrep15220_CR5","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.meatsci.2012.09.018","volume":"93","author":"P Pereira","year":"2013","unstructured":"Pereira, P. & Vicente, A. Meat nutritional composition and nutritive role in the human diet. Meat Sci. 93, 586\u2013592 (2013).","journal-title":"Meat Sci."},{"key":"BFsrep15220_CR6","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1001\/archinternmed.2012.4111","volume":"172","author":"A Pan","year":"2012","unstructured":"Pan, A. et al. Red meat consumption and mortality: results from 2 prospective cohort studies. Arch. Intern. Med. 172, 555\u2013563 (2012).","journal-title":"Arch. Intern. Med."},{"key":"BFsrep15220_CR7","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/nature06244","volume":"449","author":"PJ Turnbaugh","year":"2007","unstructured":"Turnbaugh, P. J. et al. The human microbiome project. Nature 449, 804\u2013810 (2007).","journal-title":"Nature"},{"key":"BFsrep15220_CR8","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1126\/science.1104816","volume":"307","author":"F B\u00e4ckhed","year":"2005","unstructured":"B\u00e4ckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A. & Gordon, J. I. Host-bacterial mutualism in the human intestine. Science 307, 1915\u20131920 (2005).","journal-title":"Science"},{"key":"BFsrep15220_CR9","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","volume":"148","author":"JC Clemente","year":"2012","unstructured":"Clemente, J. C., Ursell, L. K., Parfrey, L. W. & Knight, R. The impact of the gut microbiota on human health: an integrative view. Cell 148, 1258\u20131270 (2012).","journal-title":"Cell"},{"key":"BFsrep15220_CR10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/jgh.12294","volume":"28","author":"BS Ramakrishna","year":"2013","unstructured":"Ramakrishna, B. S. Role of the gut microbiota in human nutrition and metabolism. J. Gastroenterol. Hepatol. 28, 9\u201317 (2013).","journal-title":"J. Gastroenterol. Hepatol."},{"key":"BFsrep15220_CR11","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.copbio.2010.12.004","volume":"22","author":"JE van Hylckama Vlieg","year":"2011","unstructured":"van Hylckama Vlieg, J. E., Veiga, P., Zhang, C., Derrien, M. & Zhao, L. Impact of microbial transformation of food on health\u2014from fermented foods to fermentation in the gastro-intestinal tract. Curr. Opin. Biotechnol. 22, 211\u2013219 (2011).","journal-title":"Curr. Opin. Biotechnol."},{"key":"BFsrep15220_CR12","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1017\/S1751731113000062","volume":"7","author":"VT Rist","year":"2013","unstructured":"Rist, V. T., Weiss, E., Eklund, M. & Mosenthin, R. Impact of dietary protein on microbiota composition and activity in the gastrointestinal tract of piglets in relation to gut health: a review. Animal. 7, 1067\u20131078 (2013).","journal-title":"Animal"},{"key":"BFsrep15220_CR13","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1038\/ismej.2012.27","volume":"6","author":"C Zhang","year":"2012","unstructured":"Zhang, C. et al. Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations. ISME J. 6, 1848\u20131857 (2012).","journal-title":"ISME J."},{"key":"BFsrep15220_CR14","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1111\/j.1348-0421.2002.tb02769.x","volume":"46","author":"H Hayashi","year":"2002","unstructured":"Hayashi, H., Sakamoto, M. & Benno, Y. Fecal microbial diversity in a strict vegetarian as determined by molecular analysis and cultivation. Microbiol. Immunol. 46, 819\u2013831 (2002).","journal-title":"Microbiol. Immunol."},{"key":"BFsrep15220_CR15","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1017\/S0007114511006362","volume":"108","author":"J Kabeerdoss","year":"2012","unstructured":"Kabeerdoss, J., Devi, R. S., Mary, R. R. & Ramakrishna, B. S. Faecal microbiota composition in vegetarians: comparison with omnivores in a cohort of young women in southern India. Brit. J. Nutr. 108, 953\u2013957 (2012).","journal-title":"Brit. J. Nutr."},{"key":"BFsrep15220_CR16","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1007\/s00394-013-0607-6","volume":"53","author":"BB Rmatijasic","year":"2014","unstructured":"Rmatijasic, B. B. et al. Association of dietary type with fecal microbiota in vegetarians and omnivores in Slovenia. Eur. J. Nutr. 53, 1051\u20131064 (2014).","journal-title":"Eur. J. Nutr."},{"key":"BFsrep15220_CR17","doi-asserted-by":"publisher","first-page":"E1125","DOI":"10.1002\/ijc.27546","volume":"131","author":"NJ Ollberding","year":"2012","unstructured":"Ollberding, N. J., Wilkens, L. R., Henderson, B. E., Kolonel, L. N. & Le Marchand, L. Meat consumption, heterocyclic amines and colorectal cancer risk: the Multiethnic Cohort Study. Int. J. Cancer 131, E1125\u2013E1133 (2012).","journal-title":"Int. J. Cancer"},{"key":"BFsrep15220_CR18","doi-asserted-by":"crossref","unstructured":"Samraj, A. N. et al. A red meat-derived glycan promotes inflammation and cancer progression. PNAS. 10.1073\/pnas.1417508112 (2014).","DOI":"10.1073\/pnas.1417508112"},{"key":"BFsrep15220_CR19","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nrmicro1152","volume":"3","author":"JK Nicholson","year":"2005","unstructured":"Nicholson, J. K., Holmes, E. & Wilson, I. D. Gut microorganisms, mammalian metabolism and personalized health care. Nat. Rev. Microbiol. 3, 431\u2013438 (2005).","journal-title":"Nat. Rev. Microbiol."},{"key":"BFsrep15220_CR20","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1038\/ismej.2010.61","volume":"4","author":"ML Marco","year":"2010","unstructured":"Marco, M. L. et al. Convergence in probiotic Lactobacillus gut-adaptive responses in humans and mice. ISME J. 4, 1481\u20131484 (2010).","journal-title":"ISME J."},{"key":"BFsrep15220_CR21","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1017\/S0007114511006957","volume":"108","author":"T Arora","year":"2012","unstructured":"Arora, T. et al. Effect of Lactobacillus acidophilus NCDC 13 supplementation on the progression of obesity in diet-induced obese mice. Brit. J. Nutr. 108, 1382\u20131389 (2012).","journal-title":"Brit. J. Nutr."},{"key":"BFsrep15220_CR22","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/ismej.2009.112","volume":"4","author":"C Zhang","year":"2009","unstructured":"Zhang, C. et al. Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. ISME J. 4, 232\u2013241 (2009).","journal-title":"ISME J."},{"key":"BFsrep15220_CR23","first-page":"1","volume":"4","author":"C Zhang","year":"2013","unstructured":"Zhang, C. et al. Structural modulation of gut microbiota in life-long calorie-restricted mice. Nat. Commun. 4, 1\u201310 (2013).","journal-title":"Nat. Commun."},{"key":"BFsrep15220_CR24","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.2337\/db06-1491","volume":"56","author":"PD Cani","year":"2007","unstructured":"Cani, P. D. et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 56, 1761\u20131772 (2007).","journal-title":"Diabetes."},{"key":"BFsrep15220_CR25","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.2337\/db07-1403","volume":"57","author":"PD Cani","year":"2008","unstructured":"Cani, P. D. et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet\u2013induced obesity and diabetes in mice. Diabetes. 57, 1470\u20131481 (2008).","journal-title":"Diabetes."},{"key":"BFsrep15220_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.mam.2012.11.001","volume":"34","author":"J Shen","year":"2013","unstructured":"Shen, J., Obin, M. S. & Zhao, L. The gut microbiota, obesity and insulin resistance. Mol. Aspects. Med. 34, 39\u201358 (2013).","journal-title":"Mol. Aspects. Med."},{"key":"BFsrep15220_CR27","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/ismej.2012.153","volume":"7","author":"N Fei","year":"2012","unstructured":"Fei, N. & Zhao, L. An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice. ISME J. 7, 880\u2013884 (2012).","journal-title":"ISME J."},{"key":"BFsrep15220_CR28","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1042\/bst0310785","volume":"31","author":"J Weiss","year":"2003","unstructured":"Weiss, J. Bactericidal\/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP): structure, function and regulation in host defence against Gram-negative bacteria. Biochem. Soc. Trans. 31, 785\u2013790 (2003).","journal-title":"Biochem. Soc. Trans."},{"key":"BFsrep15220_CR29","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.2337\/dc10-0340","volume":"33","author":"L Sun","year":"2010","unstructured":"Sun, L. et al. A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese. Diabetes. Care. 33, 1925\u20131932 (2010).","journal-title":"Diabetes. Care."},{"key":"BFsrep15220_CR30","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.micinf.2005.10.006","volume":"8","author":"J Zweigner","year":"2006","unstructured":"Zweigner, J., Schumann, R. R. & Weber, J. R. The role of lipopolysaccharide-binding protein in modulating the innate immune response. Microbes. Infect. 8, 946\u2013952 (2006).","journal-title":"Microbes. Infect."},{"key":"BFsrep15220_CR31","doi-asserted-by":"publisher","first-page":"S133","DOI":"10.1093\/clinids\/12.Supplement_2.S133","volume":"12","author":"A Lindberg","year":"1990","unstructured":"Lindberg, A. et al. Structure-activity relationships in lipopolysaccharides of Bacteroides fragilis. Clin. Infect. Dis. 12, S133\u2013S141 (1990).","journal-title":"Clin. Infect. Dis."},{"key":"BFsrep15220_CR32","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/nature05414","volume":"444","author":"PJ Turnbaugh","year":"2006","unstructured":"Turnbaugh, P. J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027\u20131031 (2006).","journal-title":"Nature"},{"key":"BFsrep15220_CR33","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","volume":"3","author":"PJ Turnbaugh","year":"2008","unstructured":"Turnbaugh, P. J., B\u00e4ckhed, F., Fulton, L. & Gordon, J. I. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe. 3, 213\u2013223 (2008).","journal-title":"Cell Host Microbe."},{"key":"BFsrep15220_CR34","doi-asserted-by":"publisher","first-page":"4153","DOI":"10.1113\/jphysiol.2009.174136","volume":"587","author":"PJ Turnbaugh","year":"2009","unstructured":"Turnbaugh, P. J. & Gordon, J. I. The core gut microbiome, energy balance and obesity. J. Physiol. 587, 4153\u20134158 (2009).","journal-title":"J. Physiol."},{"key":"BFsrep15220_CR35","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/nature07540","volume":"457","author":"PJ Turnbaugh","year":"2009","unstructured":"Turnbaugh, P. J. et al. A core gut microbiome in obese and lean twins. Nature 457, 480\u2013484 (2009).","journal-title":"Nature"},{"key":"BFsrep15220_CR36","doi-asserted-by":"publisher","first-page":"398","DOI":"10.3945\/ajcn.2009.28713","volume":"92","author":"A-C Vergnaud","year":"2010","unstructured":"Vergnaud, A.-C. et al. Meat consumption and prospective weight change in participants of the EPIC-PANACEA study. Am. J. Clin. Nutr. 92, 398\u2013407 (2010).","journal-title":"Am. J. Clin. Nutr."},{"key":"BFsrep15220_CR37","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/ijo.2009.45","volume":"33","author":"Y Wang","year":"2009","unstructured":"Wang, Y. & Beydoun, M. A. Meat consumption is associated with obesity and central obesity among US adults. Int. J. Obes. 33, 621\u2013628, 10.1038\/ijo.2009.45 (2009).","journal-title":"Int. J. Obes."},{"key":"BFsrep15220_CR38","doi-asserted-by":"publisher","first-page":"B16","DOI":"10.1016\/j.numecd.2010.12.008","volume":"21","author":"JA Gilbert","year":"2011","unstructured":"Gilbert, J. A., Bendsen, N. T., Tremblay, A. & Astrup, A. Effect of proteins from different sources on body composition. Nutr. Metab. Cardiovase. Dis. 21 Suppl 2, B16\u201331 (2011).","journal-title":"Nutr. Metab. Cardiovase. Dis"},{"key":"BFsrep15220_CR39","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3945\/an.112.002071","volume":"3","author":"M Journel","year":"2012","unstructured":"Journel, M., Chaumontet, C., Darcel, N., Fromentin, G. & Tome, D. Brain responses to high-protein diets. Adv. Nutr. 3, 322\u2013329 (2012).","journal-title":"Adv. Nutr"},{"key":"BFsrep15220_CR40","unstructured":"Fund, W. C. R. & Research, A. I. f. C. Food, nutrition, physical activity and the prevention of cancer: a global perspective. (Amer Inst for Cancer Research, 2007)."},{"key":"BFsrep15220_CR41","doi-asserted-by":"publisher","first-page":"e90849","DOI":"10.1371\/journal.pone.0090849","volume":"9","author":"Q Zhu","year":"2014","unstructured":"Zhu, Q. et al.Analysis of the intestinal lumen microbiota in an animal model of colorectal cancer. PloS One. 9, e90849, 10.1371\/journal.pone.0090849 (2014).","journal-title":"PloS One."},{"key":"BFsrep15220_CR42","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1177\/1756283X13482996","volume":"6","author":"CM Guinane","year":"2013","unstructured":"Guinane, C. M. & Cotter, P. D. Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ. Therap. Adv. Gastroenterol. 6, 295\u2013308 (2013).","journal-title":"Therap. Adv. Gastroenterol"},{"key":"BFsrep15220_CR43","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","volume":"123","author":"PG Reeves","year":"1993","unstructured":"Reeves, P. G., Nielsen, F. H. & Fahey Jr, G. C. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J.Nutr. 123, 1939\u20131951 (1993).","journal-title":"J.Nutr."},{"key":"BFsrep15220_CR44","doi-asserted-by":"publisher","first-page":"3557","DOI":"10.1128\/AEM.67.8.3557-3563.2001","volume":"67","author":"A Schmalenberger","year":"2001","unstructured":"Schmalenberger, A., Schwieger, F. & Tebbe, C. C. Effect of primers hybridizing to different evolutionarily conserved regions of the small-subunit rRNA gene in PCR-based microbial community analyses and genetic profiling. Appl. Environ. Microbiol. 67, 3557\u20133563 (2001).","journal-title":"Appl. Environ. Microbiol."},{"key":"BFsrep15220_CR45","doi-asserted-by":"publisher","first-page":"5261","DOI":"10.1128\/AEM.00062-07","volume":"73","author":"Q Wang","year":"2007","unstructured":"Wang, Q., Garrity, G. M., Tiedje, J. M. & Cole, J. R. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl. Environ. Microbiol. 73, 5261\u20135267 (2007).","journal-title":"Appl. Environ. Microbiol."},{"key":"BFsrep15220_CR46","doi-asserted-by":"publisher","first-page":"D590","DOI":"10.1093\/nar\/gks1219","volume":"41","author":"C Quast","year":"2013","unstructured":"Quast, C. et al. The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Nucleic. Acids. Res. 41, D590\u2013D596 (2013).","journal-title":"Nucleic. Acids. Res."},{"key":"BFsrep15220_CR47","doi-asserted-by":"publisher","first-page":"7537","DOI":"10.1128\/AEM.01541-09","volume":"75","author":"PD Schloss","year":"2009","unstructured":"Schloss, P. D. et al. Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Appl. Environ. Microbiol. 75, 7537\u20137541 (2009).","journal-title":"Appl. Environ. Microbiol."},{"key":"BFsrep15220_CR48","doi-asserted-by":"publisher","first-page":"e27310","DOI":"10.1371\/journal.pone.0027310","volume":"6","author":"PD Schloss","year":"2011","unstructured":"Schloss, P. D., Gevers, D. & Westcott, S. L. Reducing the effects of PCR amplification and sequencing artifacts on 16S rRNA-based studies. PloS One. 6, e27310 (2011).","journal-title":"PloS One."},{"key":"BFsrep15220_CR49","doi-asserted-by":"publisher","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","volume":"12","author":"N Segata","year":"2011","unstructured":"Segata, N. et al. Metagenomic biomarker discovery and explanation. Genome. Biol. 12, R60 (2011).","journal-title":"Genome. Biol."},{"key":"BFsrep15220_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1465-6906-12-S1-P17","volume":"12","author":"JN Paulson","year":"2011","unstructured":"Paulson, J. N., Pop, M. & Bravo, H. C. Metastats: an improved statistical method for analysis of metagenomic data. Genome. Biol. 12, 1\u201327 (2011).","journal-title":"Genome. Biol."}],"updated-by":[{"DOI":"10.1038\/srep16546","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T00:00:00Z","timestamp":1447718400000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep15220.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep15220","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep15220.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T15:21:22Z","timestamp":1672932082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep15220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,14]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12,7]]}},"alternative-id":["BFsrep15220"],"URL":"https:\/\/doi.org\/10.1038\/srep15220","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,14]]},"assertion":[{"value":"30 March 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2015","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has been fixed in the paper.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15220"}}