{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T05:14:40Z","timestamp":1771737280147,"version":"3.50.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The human genome with all its ethnic variations contributes to differences in human development, aging, disease, repair and response to medical treatments and is an exciting area of research and clinical study. The availability of well-characterized ethnically diverse stem cell lines is limited and has not kept pace with other advances in stem cell research. Here we derived xenofree ethnically diverse-human induced pluripotent stem cell (ED-iPSC) lines from fibroblasts obtained from individuals of African American, Hispanic-Latino, Asian and Caucasian ethnic origin and have characterized the lines under a uniform platform for comparative analysis. Derived ED-iPSC lines are low passage number and evaluated <jats:italic>in vivo<\/jats:italic> by teratoma formation and <jats:italic>in vitro<\/jats:italic> by high throughput microarray analysis of EB formation and early differentiation for tri-lineage commitment to endoderm, ectoderm and mesoderm. These new xenofree ED-iPSC lines represent a well-characterized valuable resource with potential for use in future research in drug discovery or clinical investigations.<\/jats:p>","DOI":"10.1038\/srep15234","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T08:59:10Z","timestamp":1445331550000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Derivation of Ethnically Diverse Human Induced Pluripotent Stem Cell Lines"],"prefix":"10.1038","volume":"5","author":[{"given":"Eun Ah","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin L.","family":"Tomov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven T.","family":"Suhr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiesi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary T.","family":"Olmsted","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet L.","family":"Paluh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Cibelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,10,20]]},"reference":[{"key":"BFsrep15234_CR1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/nrg3563","volume":"15","author":"V Tabar","year":"2014","unstructured":"Tabar, V. & Studer, L. Pluripotent stem cells in regenerative medicine: challenges and recent progress. Nat. Rev. Genet. 15, 82\u201392 (2014).","journal-title":"Nat. Rev. Genet."},{"key":"BFsrep15234_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/labinvest.2014.104","volume":"95","author":"KE Santostefano","year":"2015","unstructured":"Santostefano, K. E., Hamazaki, T., Biel, N. M., Jin, S., Umezawa, A. & Terada, N. Pathobiology in Focus: A practical guide to induced pluripotent stem cell research using patient samples. Laboratory Investigation. 95, 4\u201313 (2015).","journal-title":"Laboratory Investigation."},{"key":"BFsrep15234_CR3","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/nrg2951","volume":"12","author":"H Zhu","year":"2011","unstructured":"Zhu, H., Lensch, M. W., Cahan, P. & Daley, G. Q. Investigating monogenic and complex diseases with pluripotent stem cells. Nat. Rev. Genet. 12, 266\u2013275 (2011).","journal-title":"Nat. Rev. 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Stem Cells Dev. 19(8), 1221\u20139 (2010).","journal-title":"Stem Cells Dev."},{"key":"BFsrep15234_CR11","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1056\/NEJMc0910371","volume":"362","author":"JT Mosher","year":"2010","unstructured":"Mosher, J. T. et al. Lack of population diversity in commonly used human embryonic stem cell lines. New England Journal of Medicine. 362(2), 183\u2013185 (2010).","journal-title":"New England Journal of Medicine."},{"key":"BFsrep15234_CR12","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.gpb.2013.08.002","volume":"11","author":"J Wang","year":"2013","unstructured":"Wang, J., et al. Generation of induced pluripotent stem cells with high efficiency from human umbilical cord blood mononuclear cells. 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