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Herein, we observed that the promoter region of the gene encoding mucin-like protocadherin (\n                    <jats:italic>MUPCDH<\/jats:italic>\n                    ) was hypermethylated in the renal tissue of patients with ADPKD compared to non-ADPKD controls. Inversely,\n                    <jats:italic>MUPCDH<\/jats:italic>\n                    was significantly repressed in ADPKD, especially in cyst-lining cells. Our results indicate that aberrant methylation of\n                    <jats:italic>MUPCDH<\/jats:italic>\n                    promoter CpG islands may be negatively correlated with reduced expression level of\n                    <jats:italic>MUPCDH<\/jats:italic>\n                    and that this contributes to abnormal cell proliferation in ADPKD. It suggests that methylation status of\n                    <jats:italic>MUPCDH<\/jats:italic>\n                    promoter can be used as a novel epigenetic biomarker and a therapeutic target in ADPKD.\n                  <\/jats:p>","DOI":"10.1038\/srep15238","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T05:24:12Z","timestamp":1444800252000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Epigenetic silencing of the MUPCDH gene as a possible prognostic biomarker for cyst growth in ADPKD"],"prefix":"10.1038","volume":"5","author":[{"given":"Yu Mi","family":"Woo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Ah","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Hwan","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Kyung","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayne Cho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon-Su","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,14]]},"reference":[{"key":"BFsrep15238_CR1","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1093\/hmg\/ddp165","volume":"18","author":"X Song","year":"2009","unstructured":"Song, X. et al. 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