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In this study, the results indicated that ZMS showed antifungal activity against <jats:italic>Peronophythora litchii<\/jats:italic> and other fungal pathogens. The activity of ZMS against the oomycete pathogen <jats:italic>P. litchi<\/jats:italic>, which causes the devastating litchi downy blight, was further investigated under <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> conditions. ZMS displayed potent inhibitory activity against the mycelial growth and sporangia germination of <jats:italic>P. litchii<\/jats:italic>. At a concentration of 2\u2009\u03bcg\/mL, about 99% of the sporangia germination was inhibited. Scanning electron microscopy and transmission electron microscopy analyses showed that treatment with ZMS could cause substantial damages to the oomycete endomembrane system. Furthermore, treatment of litchi fruits with ZMS solution significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) reduced the fruits decay and peel browning caused by <jats:italic>P. litchii<\/jats:italic> infection during storage at 28\u2009\u00b0C. Taken together, our results provide useful clues on the antifungal mechanisms of ZMS and highlight the promising potentials of ZMS as a fungicide, which in particular, may be useful for prevention and control of litchi fruits decay and browning caused by <jats:italic>P. litchii<\/jats:italic> infection during storage and transportation.<\/jats:p>","DOI":"10.1038\/srep15719","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T10:56:27Z","timestamp":1445856987000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Control of litchi downy blight by zeamines produced by Dickeya zeae"],"prefix":"10.1038","volume":"5","author":[{"given":"Lisheng","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huishan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zide","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian-Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,26]]},"reference":[{"key":"BFsrep15719_CR1","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1080\/00275514.1978.12020238","volume":"70","author":"C Chen","year":"1978","unstructured":"Chen, C. & Leu, L. 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