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We demonstrate that obese mice, generated from a high fat diet (HFD) or by genetic mutations (i.e.,\n                    <jats:italic>ob\/ob<\/jats:italic>\n                    ;\n                    <jats:italic>db\/db<\/jats:italic>\n                    ), have greatly reduced ROL levels in multiple organs, including liver, lungs, pancreas and kidneys, even though their diets have adequate VA. However, obese mice exhibit elevated serum VA. Organs from obese mice show impaired VA transcriptional signaling, including reductions in retinoic acid receptor (RAR\u03b1, RAR\u03b22 and RAR\u03b3) mRNAs and lower intracellular ROL binding protein Crbp1 (RBP1) levels in VA-storing stellate cells. Reductions in organ VA signaling in obese mice correlate with increasing adiposity and fatty liver (steatosis), while with weight loss VA levels and signaling normalize. Consistent with our findings in obese mice, we show that increasing severity of fatty liver disease in humans correlates with reductions in hepatic VA, VA transcriptional signaling and Crbp1 levels in VA storing stellate cells. Thus, obesity causes a \u201csilent\u201d VA deficiency marked by reductions in VA levels and signaling in multiple organs, but not detected by serum VA.\n                  <\/jats:p>","DOI":"10.1038\/srep15893","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T05:05:03Z","timestamp":1446440703000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Obesity Leads to Tissue, but not Serum Vitamin A Deficiency"],"prefix":"10.1038","volume":"5","author":[{"given":"Steven E.","family":"Trasino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Han","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Jessurun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine J.","family":"Gudas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,2]]},"reference":[{"key":"BFsrep15893_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3390\/nu3010063","volume":"3","author":"DN D\u2019Ambrosio","year":"2011","unstructured":"D\u2019Ambrosio, D. 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