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Astrocyte activation may occur in presymptomatic Alzheimer\u2019s disease (AD) because reactive astrocytes surround \u03b2-amyloid (A\u03b2) plaques in autopsy brain tissue. Positron emission tomography was performed to investigate fibrillar A\u03b2, astrocytosis and cerebral glucose metabolism with the radiotracers <jats:sup>11<\/jats:sup>C-Pittsburgh compound-B (PIB), <jats:sup>11<\/jats:sup>C-deuterium-L-deprenyl (DED) and <jats:sup>18<\/jats:sup>F-fluorodeoxyglucose (FDG) respectively in presymptomatic and symptomatic ADAD participants (n\u2009=\u200921), patients with mild cognitive impairment (n\u2009=\u200911) and sporadic AD (n\u2009=\u20097). Multivariate analysis using the combined data from all radiotracers clearly separated the different groups along the first and second principal components according to increased PIB retention\/decreased FDG uptake (component 1) and increased DED binding (component 2). Presymptomatic ADAD mutation carriers showed significantly higher PIB retention than non-carriers in all brain regions except the hippocampus. DED binding was highest in presymptomatic ADAD mutation carriers. This suggests that non-fibrillar A\u03b2 or early stage plaque depostion might interact with inflammatory responses indicating astrocytosis as an early contributory driving force in AD pathology. 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