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Evidence from early genetic epidemiological studies has indicated a major role for genetics in the development of osteoporosis and the variation in BMD. In this study, we focused on two key genes in the endochondral ossification pathway, <jats:italic>IBSP<\/jats:italic> and <jats:italic>PTHLH<\/jats:italic>. Over 9,000 postmenopausal Han Chinese women were recruited and 54 SNPs were genotyped. Two significant SNPs within <jats:italic>IBSP<\/jats:italic>, rs1054627 and rs17013181, were associated with BMD and postmenopausal osteoporosis by the two-stage strategy and rs17013181 was also significantly associated with serum IBSP levels. Moreover, one haplotype (rs12425376-rs10843047-rs42294) covering the 5\u2019 end of <jats:italic>PTHLH<\/jats:italic> was associated with postmenopausal osteoporosis. Our results provide evidence for the association of these two key endochondral ossification pathway genes with BMD and osteoporosis in postmenopausal Han Chinese women. Combined with previous findings, we provide evidence that a particular SNP in <jats:italic>IBSP<\/jats:italic> has an allele-specific effect on mRNA levels, which would, in turn, reflect serum IBSP levels.<\/jats:p>","DOI":"10.1038\/srep16783","type":"journal-article","created":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T10:51:54Z","timestamp":1447671114000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Endochondral ossification pathway genes and postmenopausal osteoporosis: Association and specific allele related serum bone sialoprotein levels in Han Chinese"],"prefix":"10.1038","volume":"5","author":[{"given":"Yunzhi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianxiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongke","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KunZheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,11,16]]},"reference":[{"key":"BFsrep16783_CR1","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.mcna.2015.01.010","volume":"99","author":"AL Golob","year":"2015","unstructured":"Golob, A. 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