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We recently demonstrated that vision is altered in <jats:italic>Drosophila<\/jats:italic> PD models and hypothesised that different types of genetic and idiopathic PD may affect dopaminergic visual signalling pathways differently. Here we asked whether visual responses in <jats:italic>Drosophila<\/jats:italic> could be used to identify PD mutations. To mimic a clinical setting a range of flies was used. Young flies from four control lines were compared to three early-onset PD mutations <jats:italic>(PINK1<\/jats:italic>, <jats:italic>DJ-1\u03b1<\/jats:italic> and <jats:italic>DJ-1\u03b2<\/jats:italic>) and to two other neurodegenerative mutations, one in the fly <jats:italic>LRRK2<\/jats:italic> orthologue (<jats:italic>dLRRK<\/jats:italic>) the other in <jats:italic>eggroll<\/jats:italic>, a model of general neurodegeneration in <jats:italic>Drosophila<\/jats:italic>. Stimuli were contrast reversing gratings spanning 64 spatiotemporal frequency combinations. We recorded the steady-state visually-evoked response amplitude across all combinations. We found that the pattern of neuronal responses differed between genotypes. Wild-type and early-onset PD flies formed separate clusters; the late-onset mutation is an outlier. Neuronal responses in early-onset PD flies were stronger than in wild-types. Multivariate pattern analysis grouped flies by PD\/non-PD genotype with an accuracy &gt;85%. We propose that machine learning algorithms may be useful in increasing the diagnostic specificity of human electrophysiological measurements in both animal models and PD patients.<\/jats:p>","DOI":"10.1038\/srep16933","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T10:49:58Z","timestamp":1448362198000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Classification of Parkinson\u2019s Disease Genotypes in Drosophila Using Spatiotemporal Profiling of Vision"],"prefix":"10.1038","volume":"5","author":[{"given":"Ryan J.H.","family":"West","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.H.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex R.","family":"Wade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,24]]},"reference":[{"key":"BFsrep16933_CR1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1176\/jnp.14.2.223","volume":"14","author":"J Parkinson","year":"2002","unstructured":"Parkinson, J. 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