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MicroRNA-155 (miR-155) could promote Th1 cells polarization. The present study aims to determine the role of miR-155 in immune response of OLP. The expression of miR-155 and the target mRNA was tested by Real-Time PCR. The serum levels of IL-2, 4, 10 and IFN-\u03b3 were examined with ELISA. Furthermore, <jats:italic>in vitro<\/jats:italic> study was built to observe the function of miR-155 in erosive-type OLP (EOLP). Finally, we determined the expression and correlation of miR-155 and SOCS1 in EOLP CD4<jats:sup>+<\/jats:sup> T cells. The results showed miR-155 was high related with the disease severities. Besides, serum IFN-\u03b3 was specifically increased in EOLP group, while IL-4 was decreased. <jats:italic>In vitro<\/jats:italic> studies showed miR-155 could reinforce IFN-\u03b3 signal transducer and the induction of IFN-\u03b3 could also promote miR-155 expression in EOLP CD4<jats:sup>+<\/jats:sup> T cells. In addition, miR-155 levels were negatively related with SOCS1 mRNA expression in EOLP CD4<jats:sup>+<\/jats:sup> T cells. Our study revealed a positive miR-155- IFN-\u03b3 feedback loop in EOLP CD4<jats:sup>+<\/jats:sup> T cell, which might contribute to the Th1-dominated immune response. Furthermore, miR-155 could be used for the evaluation and treatment of OLP.<\/jats:p>","DOI":"10.1038\/srep16935","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T10:41:25Z","timestamp":1448275285000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["MicroRNA-155-IFN-\u03b3 Feedback Loop in CD4+T Cells of Erosive type Oral Lichen Planus"],"prefix":"10.1038","volume":"5","author":[{"given":"Jing-Yu","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Zhi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Yi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan-Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge-Fei","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,11,23]]},"reference":[{"key":"BFsrep16935_CR1","unstructured":"Gale, N., Pilch, B. 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