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After optimization of blood glucose in the first 3 days by CSII during hospitalization, patients with poorly controlled T2DM were randomized to receive CSII combined with injections of exenatide or placebo for another 3 days. A total of 51 patients (30 in exenatide and 21 in placebo groups) with mean A1C 11% were studied. There was no difference in mean glucose but a significant higher standard deviation of plasma glucose (SDPG) was found in the exenatide group (50.51\u2009\u00b1\u20092.43\u2009vs. 41.49\u2009\u00b1\u20093.00\u2009mg\/dl, <jats:italic>p<\/jats:italic>\u2009=\u20090.027). The improvement of incremental area under the curve (AUC) of glucose and insulinogenic index (Insulin<jats:sub>0\u2013peak<\/jats:sub>\/ Glucose<jats:sub>0\u2013peak<\/jats:sub>) in 75\u2009g oral glucose tolerance test was prominent in the exenatide group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The adiponectin level was significantly increased with exenatide added on (0.39\u2009\u00b1\u20090.32\u2009vs. \u22121.62\u2009\u00b1\u20090.97\u2009\u03bcg\/mL, in exenatide and placebo groups, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.045). In conclusion, the add-on of GLP-1 analogue to CSII increased glucose variability and the \u03b2 - cell response in patients with poorly controlled T2DM.<\/jats:p>","DOI":"10.1038\/srep16968","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T10:12:45Z","timestamp":1448532765000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Glucose Variability and \u03b2- Cell Response by GLP-1 Analogue added-on CSII for Patients with Poorly Controlled Type 2 Diabetes"],"prefix":"10.1038","volume":"5","author":[{"given":"Chia-Hung","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Hwu","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui-Hung","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jir-Shiong","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Yao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,26]]},"reference":[{"key":"BFsrep16968_CR1","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1053\/j.gastro.2007.03.054","volume":"132","author":"LL Baggio","year":"2007","unstructured":"Baggio, L. 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