{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:55:57Z","timestamp":1775678157869,"version":"3.50.1"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Depression is one of the major side effects of interferon alpha (IFN-\u03b1) treatment, but the molecular mechanism underlying IFN-\u03b1-induced depression remains unclear. Several studies have shown that the serotonin receptors 5-HTR1b and 5-HTR4 play key roles in the anti-depression effects associated with p11 (S100A10). We investigated the effects of IFN-\u03b1 on the regulation of p11, 5-HTR1b and 5-HTR4 in mice and human neuroblastoma cells (SH-sy5y). We found that intraperitoneal injection with IFN-\u03b1 in Balb\/c mice resulted in an increased immobility in FST and TST and potently lowered the protein levels of p11, 5-HTR1b and 5-HTR4 in the hippocampus or cingulate gyrus. IFN-\u03b1 significantly down-regulated the protein levels of p11, 5-HTR1b and 5-HTR4 in SH-sy5y cells, in a time- and dose-dependent manner. Our study revealed that over-expression of p11 could prevent the IFN-\u03b1-induced down-regulation of 5-HTR1b and 5-HTR4. The results indicated that IFN-\u03b1 treatment resulted in p11 down-regulation, which subsequently decreased 5-HTR1b and 5-HTR4 <jats:italic>in vitro<\/jats:italic> or <jats:italic>in vivo<\/jats:italic>. Our findings suggested that p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-\u03b1-induced depression.<\/jats:p>","DOI":"10.1038\/srep17029","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T10:39:29Z","timestamp":1454063969000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Probable involvement of p11 with interferon alpha induced depression"],"prefix":"10.1038","volume":"6","author":[{"given":"Jiqiang","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaxia","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinming","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianzhang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haojiang","family":"Luan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,1,29]]},"reference":[{"key":"BFsrep17029_CR1","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s12072-010-9214-2","volume":"5","author":"S Shimomura","year":"2010","unstructured":"Shimomura, S. et al. Long-term interferon therapy after radiofrequency ablation is effective in treating patients with HCV-associated hepatocellular carcinoma. Hepa. Inter. 5, 559\u2013566, 10.1007\/s12072-010-9214-2 (2010).","journal-title":"Hepa. Inter."},{"key":"BFsrep17029_CR2","first-page":"166","volume":"6","author":"JC Ma","year":"2007","unstructured":"Ma, J. C. et al. Relationship between HBV genotypes and anti-viral therapeutic efficacy of interferon-alpha. Hepatobiliary & pancreatic diseases international : HBPD. INT. 6, 166\u2013171 (2007).","journal-title":"Hepatobiliary & pancreatic diseases international : HBPD. INT."},{"key":"BFsrep17029_CR3","first-page":"180","volume":"24","author":"J Vanaskova","year":"2011","unstructured":"Vanaskova, J., Grim, J., Kopecky, J., Kubala, E. & Filip, S. [High-dose interferon alpha in treatment of patients with malignant melanoma, monitoring of predictive and prognostic biomarkers. Klin Onkol. 24, 180\u2013186 (2011).","journal-title":"Klin Onkol."},{"key":"BFsrep17029_CR4","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s12253-014-9777-7","volume":"20","author":"P Kovacs","year":"2014","unstructured":"Kovacs, P., Panczel, G., Borbola, K., Juhasz, G. & Liszkay, G. Psychological Changes in Melanoma Patients During Ipilimumab Treatment Compared to Low-Dose Interferon Alpha Therapy-A Follow-Up Study of First Experiences. Pathol. Oncol. Res. 20, 939\u2013944 (2014).","journal-title":"Pathol. Oncol. Res."},{"key":"BFsrep17029_CR5","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.jhep.2012.07.037","volume":"57","author":"M Schaefer","year":"2012","unstructured":"Schaefer, M. et al. Hepatitis C infection, antiviral treatment and mental health: a European expert consensus statement. J. Hepatol. 57, 1379\u20131390 (2012).","journal-title":"J. Hepatol."},{"key":"BFsrep17029_CR6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/JCP.0b013e31825d9982","volume":"32","author":"S Baraldi","year":"2012","unstructured":"Baraldi, S., Hepgul, N., Mondelli, V. & Pariante, C. M. Symptomatic treatment of interferon-alpha-induced depression in hepatitis C: a systematic review. J. Clin. Psychopharmacol. 32, 531\u2013543 (2012).","journal-title":"J. Clin. Psychopharmacol."},{"key":"BFsrep17029_CR7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2174\/092986711794088353","volume":"18","author":"M Catena-Dell\u2019Osso","year":"2011","unstructured":"Catena-Dell\u2019Osso, M. et al. Inflammatory and neurodegenerative pathways in depression: a new avenue for antidepressant development? Curr. Med. Chem. 18, 245\u2013255 (2011).","journal-title":"Curr. Med. Chem."},{"key":"BFsrep17029_CR8","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.bbi.2009.07.001","volume":"23","author":"AA Prather","year":"2009","unstructured":"Prather, A. A., Rabinovitz, M., Pollock, B. G. & Lotrich, F. E. Cytokine-induced depression during IFN-alpha treatment: the role of IL-6 and sleep quality. Brain. Behav. Immun. 23, 1109\u20131116 (2009).","journal-title":"Brain. Behav. Immun."},{"key":"BFsrep17029_CR9","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.jpsychires.2010.03.005","volume":"44","author":"H Himmerich","year":"2010","unstructured":"Himmerich, H. et al. Regulatory T cells increased while IL-1beta decreased during antidepressant therapy. J. Psychiatr. Res. 44, 1052\u20131057 (2010).","journal-title":"J. Psychiatr. Res."},{"key":"BFsrep17029_CR10","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.bbi.2011.02.015","volume":"25","author":"JC Felger","year":"2011","unstructured":"Felger, J. C. et al. Early activation of p38 mitogen activated protein kinase is associated with interferon-alpha-induced depression and fatigue. Brain. Behav. Immun. 25, 1094\u20131098 (2011).","journal-title":"Brain. Behav. Immun."},{"key":"BFsrep17029_CR11","first-page":"37","volume":"3","author":"J Illman","year":"2005","unstructured":"Illman, J. et al. Are inflammatory cytokines the common link between cancer-associated cachexia and depression? J. Support. Oncol. 3, 37\u201350 (2005).","journal-title":"J. Support. Oncol."},{"key":"BFsrep17029_CR12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/mp.2008.58","volume":"15","author":"CL Raison","year":"2010","unstructured":"Raison, C. L. et al. Interferon-alpha effects on diurnal hypothalamic-pituitary-adrenal axis activity: relationship with proinflammatory cytokines and behavior. Mol. Psychiatr. 15, 535\u2013547 (2010).","journal-title":"Mol. Psychiatr."},{"key":"BFsrep17029_CR13","first-page":"11","volume":"29","author":"MC Wichers","year":"2004","unstructured":"Wichers, M. C. & Maes, M. The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression. J. Psychiatry Neurosci. 29, 11\u201317 (2004).","journal-title":"J. Psychiatry Neurosci."},{"key":"BFsrep17029_CR14","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/mp.2011.67","volume":"17","author":"AK Smith","year":"2012","unstructured":"Smith, A. K. et al. Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-alpha-induced depression in patients with chronic hepatitis C. Mol. Psychiatr. 17, 781\u2013789 (2012).","journal-title":"Mol. Psychiatr."},{"key":"BFsrep17029_CR15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000108382","volume":"55","author":"M Bannink","year":"2007","unstructured":"Bannink, M. et al. Interferon-alpha influences tryptophan metabolism without inducing psychiatric side effects. Neuropsychobiology 55, 225\u2013231 (2007).","journal-title":"Neuropsychobiology"},{"key":"BFsrep17029_CR16","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.bbi.2011.06.001","volume":"25","author":"A Galvao-de Almeida","year":"2011","unstructured":"Galvao-de Almeida, A. et al. Lack of association of indoleamine 2,3-dioxygenase polymorphisms with interferon-alpha-related depression in hepatitis C. Brain. Behav. Immun. 25, 1491\u20131497 (2011).","journal-title":"Brain. Behav. Immun."},{"key":"BFsrep17029_CR17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.1117571","volume":"311","author":"P Svenningsson","year":"2006","unstructured":"Svenningsson, P. et al. Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 311, 77\u201380 (2006).","journal-title":"Science"},{"key":"BFsrep17029_CR18","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1523\/JNEUROSCI.5343-08.2009","volume":"29","author":"JL Warner-Schmidt","year":"2009","unstructured":"Warner-Schmidt, J. L. et al. Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation. J. Neurosci. 29, 1937\u20131946 (2009).","journal-title":"J. Neurosci."},{"key":"BFsrep17029_CR19","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1017\/S1461145711000940","volume":"15","author":"PA Melas","year":"2012","unstructured":"Melas, P. A. et al. Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression. Int. J. Neuropsychopharmacol. 15, 669\u2013679 (2012).","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"BFsrep17029_CR20","doi-asserted-by":"crossref","unstructured":"Chen, G., Twyman, R. & Manji, H. K. p11 and gene therapy for severe psychiatric disorders: a practical goal? Sci. Transl. Med. 2, 54ps51 (2010).","DOI":"10.1126\/scitranslmed.3001754"},{"key":"BFsrep17029_CR21","first-page":"131","volume":"33","author":"H Anisman","year":"2008","unstructured":"Anisman, H. et al. Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects. J. Psychiatry Neurosci. 33, 131\u2013141 (2008).","journal-title":"J. Psychiatry Neurosci."},{"key":"BFsrep17029_CR22","doi-asserted-by":"crossref","first-page":"54ra76","DOI":"10.1126\/scitranslmed.3001079","volume":"2","author":"B Alexander","year":"2010","unstructured":"Alexander, B. et al. Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. Sci. Transl. Med. 2, 54ra76 (2010).","journal-title":"Sci. Transl. Med."},{"key":"BFsrep17029_CR23","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.biopsych.2010.01.024","volume":"67","author":"M Egeland","year":"2010","unstructured":"Egeland, M., Warner-Schmidt, J., Greengard, P. & Svenningsson, P. Neurogenic effects of fluoxetine are attenuated in p11 (S100A10) knockout mice. Biol. Psychiatry 67, 1048\u20131056 (2010).","journal-title":"Biol. Psychiatry"},{"key":"BFsrep17029_CR24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainresbull.2006.04.004","volume":"70","author":"S Rutz","year":"2006","unstructured":"Rutz, S. et al. Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain Res. Bull. 70, 81\u201393 (2006).","journal-title":"Brain Res. Bull."},{"key":"BFsrep17029_CR25","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nn.3355","volume":"16","author":"X Cai","year":"2013","unstructured":"Cai, X. et al. Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression. Nat. Neurosci. 16, 464\u2013472 (2013).","journal-title":"Nat. Neurosci."},{"key":"BFsrep17029_CR26","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nn.3355","volume":"16","author":"E Tatarczynska","year":"2013","unstructured":"Tatarczynska, E., Klodzinska, A., Stachowicz, K. & Chojnacka-Wojcik, E. Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression. Nat. Neurosci. 16, 464\u2013472 (2013).","journal-title":"Nat. Neurosci."},{"key":"BFsrep17029_CR27","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.neuint.2010.01.003","volume":"56","author":"CL Licht","year":"2010","unstructured":"Licht, C. L. et al. Changes in 5-HT4 receptor and 5-HT transporter binding in olfactory bulbectomized and glucocorticoid receptor heterozygous mice. Neurochem. Int. 56, 603\u2013610 (2010).","journal-title":"Neurochem. Int."},{"key":"BFsrep17029_CR28","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/npp.2013.332","volume":"39","author":"I Mendez-David","year":"2014","unstructured":"Mendez-David, I. et al. Rapid anxiolytic effects of a 5-HT(4) receptor agonist are mediated by a neurogenesis-independent mechanism. Neuropsychopharmacol 39, 1366\u20131378 (2014).","journal-title":"Neuropsychopharmacol"},{"key":"BFsrep17029_CR29","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.2174\/138945009789735192","volume":"10","author":"BM Ruf","year":"2009","unstructured":"Ruf, B. M. & Bhagwagar, Z. The 5-HT1B receptor: a novel target for the pathophysiology of depression. Curr. Drug. Targets 10, 1118\u20131138 (2009).","journal-title":"Curr. Drug. Targets"},{"key":"BFsrep17029_CR30","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.2174\/13816128113196660734","volume":"20","author":"R Vidal","year":"2014","unstructured":"Vidal, R. et al. Serotonin 5-HT4 receptors: A new strategy for developing fast acting antidepressants? Curr. Pharm. Des. 20, 3751\u20133762 (2014).","journal-title":"Curr. Pharm. Des."},{"key":"BFsrep17029_CR31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1017\/S1461145710000830","volume":"14","author":"G Kenis","year":"2011","unstructured":"Kenis, G. et al. Depressive symptoms following interferon-alpha therapy: mediated by immune-induced reductions in brain-derived neurotrophic factor? Int. J. Neuropsychopharmacol. 14, 247\u2013253 (2011).","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"BFsrep17029_CR32","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.cgh.2013.04.035","volume":"12","author":"HY Jiang","year":"2014","unstructured":"Jiang, H. Y. et al. Specific Serotonin Reuptake Inhibitors Prevent Interferon-alpha-induced Depression in Patients with Hepatitis C: A Meta-analysis. Clin. Gastroenterol. Hepatol. 12, 1452\u20131460 (2014).","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"BFsrep17029_CR33","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jpsychires.2010.08.012","volume":"45","author":"L Zhang","year":"2011","unstructured":"Zhang, L. et al. P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide. J. Psychiatr. Res. 45, 435\u2013441 (2011).","journal-title":"J. Psychiatr. Res."},{"key":"BFsrep17029_CR34","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/mp.2012.130","volume":"18","author":"TM Eriksson","year":"2013","unstructured":"Eriksson, T. M. et al. Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Mol. Psychiatry 18, 1096\u20131105 (2013).","journal-title":"Mol. Psychiatry"},{"key":"BFsrep17029_CR35","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000201718","volume":"58","author":"AS Orsal","year":"2008","unstructured":"Orsal, A. S., Blois, S. M., Bermpohl, D., Schaefer, M. & Coquery, N. Administration of interferon-alpha in mice provokes peripheral and central modulation of immune cells, accompanied by behavioral effects. Neuropsychobiology 58, 211\u2013222 (2008).","journal-title":"Neuropsychobiology"},{"key":"BFsrep17029_CR36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4103\/0019-5545.86815","volume":"53","author":"NK Siddegowda","year":"2011","unstructured":"Siddegowda, N. K., Kumar Rao, N. S. & Andrade, C. Development of a murine animal model of depression for repeated dosing with human interferon alpha. Indian J. Psychiatry 53, 239\u2013243 (2011).","journal-title":"Indian J. Psychiatry"},{"key":"BFsrep17029_CR37","doi-asserted-by":"crossref","unstructured":"Hoyo-Becerra, C. et al. Rapid Regulation of Depression-Associated Genes in a New Mouse Model Mimicking Interferon-alpha-Related Depression in Hepatitis C Virus Infection. Mol. Neurobiol. 10.1007\/s12035-014-8861-z (2014).","DOI":"10.1007\/s12035-014-8861-z"},{"key":"BFsrep17029_CR38","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/j.1460-2075.1987.tb04795.x","volume":"6","author":"H Weber","year":"1987","unstructured":"Weber, H., Valenzuelal, D., Lujber, G., Gubler, M. & Weissmann, C. Single amino acid changes that render human IFN-a2 biologically. EMBO J. 6, 591\u2013598 (1987).","journal-title":"EMBO J."},{"key":"BFsrep17029_CR39","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1096\/fj.07-8585com","volume":"21","author":"J Kumaran","year":"2007","unstructured":"Kumaran, J., Wei, L., Kotra, L. P. & Fish, E. N. A structural basis for interferon-alpha-receptor interactions. FASEB J. 21, 3288\u20133296 (2007).","journal-title":"FASEB J."},{"key":"BFsrep17029_CR40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.neulet.2013.11.034","volume":"559","author":"SS Shrestha","year":"2014","unstructured":"Shrestha, S. S. et al. Antidepressant effects on serotonin 1A\/1B receptors in the rat brain using a gene x environment model. Neurosci. Lett. 559, 163\u2013168 (2014).","journal-title":"Neurosci. Lett."},{"key":"BFsrep17029_CR41","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1124\/jpet.113.203315","volume":"347","author":"S Shim","year":"2013","unstructured":"Shim, S., El Mansari, M. & Blier, P. Modulation of the antidepressant-like effects of sustained administration of carisbamate and lamotrigine on monoaminergic systems: electrophysiological studies in the rat brain. J. Pharm. Exp. Ther. 347, 487\u2013496 (2013).","journal-title":"J. Pharm. Exp. Ther."},{"key":"BFsrep17029_CR42","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1001\/archgenpsychiatry.2011.91","volume":"68","author":"JW Murrough","year":"2011","unstructured":"Murrough, J. W. et al. The effect of early trauma exposure on serotonin type 1B receptor expression revealed by reduced selective radioligand binding. Arch. Gen. Psychiatry 68, 892\u2013900 (2011).","journal-title":"Arch. Gen. Psychiatry"},{"key":"BFsrep17029_CR43","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1523\/JNEUROSCI.4874-09.2010","volume":"30","author":"BY Hayden","year":"2010","unstructured":"Hayden, B. Y. & Platt, M. L. Neurons in anterior cingulate cortex multiplex information about reward and action. J. Neurosci. 30, 3339\u20133346 (2010).","journal-title":"J. Neurosci."},{"key":"BFsrep17029_CR44","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.fct.2013.07.037","volume":"60","author":"G Luo","year":"2013","unstructured":"Luo, G., Wei, R., Niu, R., Wang, C. & Wang, J. Pubertal exposure to Bisphenol A increases anxiety-like behavior and decreases acetylcholinesterase activity of hippocampus in adult male mice. Food Chem. Toxicol. 60, 177\u2013180 (2013).","journal-title":"Food Chem. Toxicol."},{"key":"BFsrep17029_CR45","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1742-2094-8-94","volume":"8","author":"J Steiner","year":"2011","unstructured":"Steiner, J. et al. Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? J. Neuroinflammation 8, 94 (2011).","journal-title":"J. Neuroinflammation"},{"key":"BFsrep17029_CR46","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/387497a0","volume":"387","author":"L Xu","year":"1997","unstructured":"Xu, L., Anwyl, R. & Rowan, M. J. Behavioural stress facilitates the induction of long-term depression in the hippocampus. Nature 387, 497\u2013500 (1997).","journal-title":"Nature"},{"key":"BFsrep17029_CR47","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1002\/hbm.22123","volume":"34","author":"ME Haahr","year":"2012","unstructured":"Haahr, M. E. et al. The 5-HT(4) receptor levels in hippocampus correlates inversely with memory test performance in humans. Hum. Brain Mapp. 34, 3066\u20133074 (2012).","journal-title":"Hum. Brain Mapp."},{"key":"BFsrep17029_CR48","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.neuropharm.2011.01.046","volume":"61","author":"M Egeland","year":"2011","unstructured":"Egeland, M., Warner-Schmidt, J., Greengard, P. & Svenningsson, P. Co-expression of serotonin 5-HT(1B) and 5-HT(4) receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum. Neuropharmacol. 61, 442\u2013450 (2011).","journal-title":"Neuropharmacol."},{"key":"BFsrep17029_CR49","first-page":"1821","volume":"13","author":"R Dittadi","year":"1993","unstructured":"Dittadi, R. et al. Comparison between western blotting, immunohistochemical and ELISA assay for p185neu quantitation in breast cancer specimens. Anticancer Res. 13, 1821\u20131824 (1993).","journal-title":"Anticancer Res."},{"key":"BFsrep17029_CR50","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrn3564","volume":"14","author":"P Svenningsson","year":"2013","unstructured":"Svenningsson, P., Kim, Y., Warner-Schmidt, J., Oh, Y. S. & Greengard, P. p11 and its role in depression and therapeutic responses to antidepressants. Nat. Rev. Neurosci. 14, 673\u2013680 (2013).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFsrep17029_CR51","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neuint.2013.11.004","volume":"73","author":"S Montanez","year":"2014","unstructured":"Montanez, S., Munn, J. L., Owens, W. A., Horton, R. E. & Daws, L. C. 5-HT1B receptor modulation of the serotonin transporter in vivo: studies using KO mice. Neurochem. Int. 73, 127\u2013131 (2014).","journal-title":"Neurochem. Int."},{"key":"BFsrep17029_CR52","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2174\/1568007043482615","volume":"3","author":"J Bockaert","year":"2004","unstructured":"Bockaert, J., Claeysen, S., Compan, V. & Dumuis, A. 5-HT4 receptors. Curr. drug targets CNS and neurol. disord. 3, 39\u201351 (2004).","journal-title":"Curr. drug targets CNS and neurol. disord."},{"key":"BFsrep17029_CR53","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/pr.2012.165","volume":"73","author":"T Aizawa-Yashiro","year":"2013","unstructured":"Aizawa-Yashiro, T. et al. Glomerular expression of fractalkine is induced by polyinosinic-polycytidylic acid in human mesangial cells: possible involvement of fractalkine after viral infection. Pediatr. Res. 73, 180\u2013186 (2013).","journal-title":"Pediatr. Res."},{"key":"BFsrep17029_CR54","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.3748\/wjg.v11.i29.4574","volume":"11","author":"YM Tang","year":"2005","unstructured":"Tang, Y. M. et al. Kinetics of phytohemaglutinin-induced IFN-gamma and TNF-alpha expression in peripheral blood mononuclear cells from patients with chronic hepatitis B after liver transplantation. WJG. 11, 4574\u20134578 (2005).","journal-title":"WJG."},{"key":"BFsrep17029_CR55","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3747\/co.v16i3.447","volume":"16","author":"A Hauschild","year":"2009","unstructured":"Hauschild, A. Adjuvant interferon alfa for melanoma: new evidence-based treatment recommendations? Curr. Oncol. 16, 3\u20136 (2009).","journal-title":"Curr. Oncol."},{"key":"BFsrep17029_CR56","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1210\/en.2012-1538","volume":"153","author":"S Tung","year":"2012","unstructured":"Tung, S., Hardy, A. B., Wheeler, M. B. & Belsham, D. D. Serotonin (5-HT) activation of immortalized hypothalamic neuronal cells through the 5-HT1B serotonin receptor. Endocrinology 153, 4862\u20134873 (2012).","journal-title":"Endocrinology"},{"key":"BFsrep17029_CR57","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1046\/j.1471-4159.2001.00550.x","volume":"79","author":"A Adell","year":"2001","unstructured":"Adell, A., Celada, P. & Artigas, F. The role of 5-HT1B receptors in the regulation of serotonin cell firing and release in the rat brain. J. Neurochem. 79, 172\u2013182 (2001).","journal-title":"J. Neurochem."},{"key":"BFsrep17029_CR58","doi-asserted-by":"crossref","first-page":"G1376","DOI":"10.1152\/ajpgi.00078.2008","volume":"294","author":"J Ren","year":"2008","unstructured":"Ren, J., Zhou, X. & Galligan, J. J. 5-HT4 receptor activation facilitates recovery from synaptic rundown and increases transmitter release from single varicosities of myenteric neurons. Am. J. Physiol. Gastrointest. liver physiol. 294, G1376\u20131383 (2008).","journal-title":"Am. J. Physiol. Gastrointest. liver physiol."},{"key":"BFsrep17029_CR59","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1460-9568.2006.04943.x","volume":"24","author":"G Conductier","year":"2006","unstructured":"Conductier, G. et al. Adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse. Eur. J. Neurosci. 24, 1053\u201362 (2006).","journal-title":"Eur. J. Neurosci."},{"key":"BFsrep17029_CR60","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000086605","volume":"52","author":"K Yoshida","year":"2005","unstructured":"Yoshida, K. et al. Promoter polymorphisms of the interferon-alpha receptor gene and development of Interferon-induced depressive symptoms in patients with chronic hepatitis C: preliminary findings. Neuropsychobiology. 52, 55\u201361 (2005).","journal-title":"Neuropsychobiology."},{"key":"BFsrep17029_CR61","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jns.2013.01.013","volume":"326","author":"O Ates","year":"2013","unstructured":"Ates, O., Karakus, N., Sezer, S. & Bozkurt, N. Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population. J. Neurol. Sci. 326, 64\u201367 (2013).","journal-title":"J. Neurol. Sci."},{"key":"BFsrep17029_CR62","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/sj.mp.4001133","volume":"7","author":"T Ohtsuki","year":"2002","unstructured":"Ohtsuki, T. et al. Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative Bipolar Pedigrees. Mol. Psychiatry. 7, 954\u2013961 (2002).","journal-title":"Mol. Psychiatry."},{"key":"BFsrep17029_CR63","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.jpsychires.2009.03.010","volume":"43","author":"TP Su","year":"2009","unstructured":"Su, T. P. et al. Levels of the potential biomarker p11 in peripheral blood cells distinguish patients with PTSD from those with other major psychiatric disorders. J. Psychiatr. Res. 43, 1078\u20131085 (2009).","journal-title":"J. Psychiatr. Res."},{"key":"BFsrep17029_CR64","first-page":"109","volume":"60","author":"H Zhang","year":"2010","unstructured":"Zhang, H., Wang, W., Jiang, Z., Shang, J. & Zhang, L. Differential involvement of 5-HT(1A) and 5-HT(1B\/1D) receptors in human interferon-alpha-induced immobility in the mouse forced swimming test. Arzneimittelforschung 60, 109\u2013115 (2010).","journal-title":"Arzneimittelforschung"},{"key":"BFsrep17029_CR65","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1099\/vir.0.83517-0","volume":"89","author":"VR Cicinnati","year":"2008","unstructured":"Cicinnati, V. R. et al. Altered chemotactic response of myeloid and plasmacytoid dendritic cells from patients with chronic hepatitis C: role of alpha interferon. J. Gen. Virol. 89, 1243\u20131253 (2008).","journal-title":"J. Gen. Virol."},{"key":"BFsrep17029_CR66","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1586\/epr.11.40","volume":"8","author":"BC Orsburn","year":"2011","unstructured":"Orsburn, B. C., Stockwin, L. H. & Newton, D. L. Challenges in plasma membrane phosphoproteomics. Expert Rev. Proteomics 8, 483\u2013494 (2011).","journal-title":"Expert Rev. Proteomics"},{"key":"BFsrep17029_CR67","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1089\/ten.tea.2013.0305","volume":"20","author":"IT Hoffecker","year":"2014","unstructured":"Hoffecker, I. T. & Iwata, H. Manipulation of Cell Sorting Within Mesenchymal Stromal Cell-Islet Cell Multicellular Spheroids. Tissue Eng. Part A 20, 11\u201312 (2014).","journal-title":"Tissue Eng. Part A"},{"key":"BFsrep17029_CR68","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/nprot.2006.4","volume":"1","author":"H Schagger","year":"2006","unstructured":"Schagger, H. Tricine-SDS-PAGE. Nat. Protoc. 1, 16\u201322 (2006).","journal-title":"Nat. Protoc."},{"key":"BFsrep17029_CR69","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/nar\/gku1185","volume":"43","author":"A Lardenois","year":"2015","unstructured":"Lardenois, A. et al. The conserved histone deacetylase Rpd3 and its DNA binding subunit Ume6 control dynamic transcript architecture during mitotic growth and meiotic development. Nucleic Acids Res. 43, 115\u2013128 (2015).","journal-title":"Nucleic Acids Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep17029","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep17029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep17029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T23:17:29Z","timestamp":1672874249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep17029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,29]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,5,10]]}},"alternative-id":["BFsrep17029"],"URL":"https:\/\/doi.org\/10.1038\/srep17029","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,29]]},"assertion":[{"value":"20 March 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17029"}}