{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:27:42Z","timestamp":1789079262883,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T00:00:00Z","timestamp":1448841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T00:00:00Z","timestamp":1448841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The affinity of zeolite nanoparticles (diameter of 8\u201312\u2009nm) possessing high surface area and high pore volume towards human plasma proteins has been investigated. The protein composition (corona) of zeolite nanoparticles has been shown to be more dependent on the plasma protein concentrations and the type of zeolites than zeolite nanoparticles concentration. The number of proteins present in the corona of zeolite nanoparticles at 100% plasma (<jats:italic>in vivo<\/jats:italic> state) is less than with 10% plasma exposure. This could be due to a competition between the proteins to occupy the corona of the zeolite nanoparticles. Moreover, a high selective adsorption for apolipoprotein C-III (APOC-III) and fibrinogen on the zeolite nanoparticles at high plasma concentration (100%) was observed. While the zeolite nanoparticles exposed to low plasma concentration (10%) exhibited a high selective adsorption for immunoglobulin gamma (i.e. IGHG1, IGHG2 and IGHG4) proteins. The zeolite nanoparticles can potentially be used for selectively capture of APOC-III in order to reduce the activation of lipoprotein lipase inhibition during hypertriglyceridemia treatment. The zeolite nanoparticles can be adapted to hemophilic patients (hemophilia A (F-VIII deficient) and hemophilia B (F-IX deficient)) with a risk of bleeding and thus might be potentially used in combination with the existing therapy.<\/jats:p>","DOI":"10.1038\/srep17259","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T10:10:46Z","timestamp":1448878246000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Zeolite Nanoparticles for Selective Sorption of Plasma Proteins"],"prefix":"10.1038","volume":"5","author":[{"given":"M.","family":"Rahimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.-P.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Bakhtiari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vinciguerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Ali","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Awala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mintova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Daghighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bakhshandeh Rostami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Motazacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Peppelenbosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Rezaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,30]]},"reference":[{"key":"BFsrep17259_CR1","doi-asserted-by":"publisher","first-page":"6734","DOI":"10.1021\/cr300439k","volume":"113","author":"V Valtchev","year":"2013","unstructured":"Valtchev, V. & Tosheva, L. Porous Nanosized Particles: Preparation, Properties and Applications. Chem. Rev. 113, 6734\u20136760 (2013).","journal-title":"Chem. Rev."},{"key":"BFsrep17259_CR2","doi-asserted-by":"publisher","first-page":"6693","DOI":"10.1039\/c3nr01629c","volume":"5","author":"S Mintova","year":"2013","unstructured":"Mintova, S., Gilson, J.-P. & Valtchev, V. Advances in nanosized zeolites. Nanoscale 5, 6693\u20136703 (2013).","journal-title":"Nanoscale"},{"key":"BFsrep17259_CR3","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.jcis.2013.05.073","volume":"406","author":"J Wu","year":"2013","unstructured":"Wu, J. et al. Protein adsorption onto nanozeolite: effect of micropore openings. J. Colloid Interf. Sci. 406, 130\u2013138 (2013).","journal-title":"J. Colloid Interf. Sci."},{"key":"BFsrep17259_CR4","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1163\/092050610X496242","volume":"22","author":"Y Zhang","year":"2011","unstructured":"Zhang, Y. et al. Zeolite\/polymer composite hollow microspheres containing antibiotics and the in vitro drug release. Journal of biomaterials science. Polymer edition 22, 809\u2013822 (2011).","journal-title":"Journal of biomaterials science. Polymer edition"},{"key":"BFsrep17259_CR5","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/jmri.1880050504","volume":"5","author":"SW Young","year":"1995","unstructured":"Young, S. W. et al. Gadolinium zeolite as an oral contrast agent for magnetic resonance imaging. Journal of magnetic resonance imaging: J. Magn. Reson. Imaging 5, 499\u2013508 (1995).","journal-title":"Journal of magnetic resonance imaging: J. Magn. Reson. Imaging"},{"key":"BFsrep17259_CR6","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.molstruc.2012.05.080","volume":"1028","author":"NS Flores-L\u00f3pez","year":"2012","unstructured":"Flores-L\u00f3pez, N. S. et al. Synthesis and properties of crystalline silver nanoparticles supported in natural zeolite chabazite. J. Mol. Struct. 1028, 110\u2013115 (2012).","journal-title":"J. Mol. Struct."},{"key":"BFsrep17259_CR7","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.micromeso.2012.04.024","volume":"167","author":"A Tavolaro","year":"2013","unstructured":"Tavolaro, A., Riccio, I. I. & Tavolaro, P. Hydrothermal synthesis of zeolite composite membranes and crystals as potential vectors for drug-delivering biomaterials. Micropor. Mesopor. Mater. 167, 62\u201370 (2013).","journal-title":"Micropor. Mesopor. Mater."},{"key":"BFsrep17259_CR8","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/chem.200500562","volume":"12","author":"T Yu","year":"2006","unstructured":"Yu, T. et al. Controlled nanozeolite-assembled electrode: remarkable enzyme-immobilization ability and high sensitivity as biosensor. Chemistry 12, 1137\u20131143 (2006).","journal-title":"Chemistry"},{"key":"BFsrep17259_CR9","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1021\/ac702218v","volume":"80","author":"J Ji","year":"2008","unstructured":"Ji, J. et al. Enhanced protein digestion through the confinement of nanozeolite-assembled microchip reactors. Anal. Chem. 80, 2457\u20132463 (2008).","journal-title":"Anal. Chem."},{"key":"BFsrep17259_CR10","doi-asserted-by":"publisher","first-page":"18040","DOI":"10.1021\/jp903989p","volume":"113","author":"Y-Y Hu","year":"2009","unstructured":"Hu, Y.-Y., Zhang, Y.-H., Ren, N. & Tang, Y. Crystal Plane- and Size-Dependent Protein Adsorption on Nanozeolite. J. Phys. Chem. C 113, 18040\u201318046 (2009).","journal-title":"J. Phys. Chem. C"},{"key":"BFsrep17259_CR11","unstructured":"Baerlocher, C., McCusker, L. & Olson, D. Atlas of zeolite framework types. Elsevier Science B.V., 2007)."},{"key":"BFsrep17259_CR12","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1039\/c3tx50023c","volume":"2","author":"S Laurent","year":"2013","unstructured":"Laurent, S. et al. Corona protein composition and cytotoxicity evaluation of ultra-small zeolites synthesized from template free precursor suspensions. Toxicol. Res. 2, 270\u2013279 (2013).","journal-title":"Toxicol. Res."},{"key":"BFsrep17259_CR13","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1055\/s-0037-1615958","volume":"85","author":"F Rezaee","year":"2001","unstructured":"Rezaee, F., Maas, a., Verheijen, J. H. & Koopman, J. Increased hepatic fibrinogen Bbeta-gene transcription is not enough to increase plasma fibrinogen levels. A transgenic mouse study. Thromb. Haemostasis 85, 1025\u20131030 (2001).","journal-title":"Thromb. Haemostasis"},{"key":"BFsrep17259_CR14","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1055\/s-0037-1613206","volume":"88","author":"F Rezaee","year":"2002","unstructured":"Rezaee, F. et al. Overexpression of fibrinogen in ApoE*3-Leiden transgenic mice does not influence the progression of diet-induced atherosclerosis. Thromb. Haemostasis 88, 329\u2013334 (2002).","journal-title":"Thromb. Haemostasis"},{"key":"BFsrep17259_CR15","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1055\/s-0037-1616079","volume":"86","author":"AA Gulledge","year":"2001","unstructured":"Gulledge, A. A., Rezaee, F., Verheijen, J. H. & Lord, S. T. A Novel Transgenic Mouse Model of Hyperfibrinogenemia. Thromb. Haemostasis 86, 511\u2013516 (2001).","journal-title":"Thromb. Haemostasis"},{"key":"BFsrep17259_CR16","doi-asserted-by":"publisher","first-page":"9414","DOI":"10.1021\/bi00103a004","volume":"30","author":"D Farrell","year":"1991","unstructured":"Farrell, D., Mulvihill, E. & Huang, S. Recombinant human fibrinogen and sulfation of the gamma\u2019 chain. Biochem. 30, 9414\u20139420 (1991).","journal-title":"Biochem."},{"key":"BFsrep17259_CR17","doi-asserted-by":"publisher","first-page":"5069","DOI":"10.1073\/pnas.77.9.5069","volume":"77","author":"C Wolfenstein-Todel","year":"1980","unstructured":"Wolfenstein-Todel, C. & Mosesson, M. W. Human plasma fibrinogen heterogeneity: evidence for an extended carboxyl-terminal sequence in a normal gamma chain variant (gamma\u2019). P. Natl. Acad. Sci. USA 77, 5069\u20135073 (1980).","journal-title":"P. Natl. Acad. Sci. USA"},{"key":"BFsrep17259_CR18","doi-asserted-by":"publisher","first-page":"30083","DOI":"10.1074\/jbc.271.47.30083","volume":"271","author":"C Redman","year":"1996","unstructured":"Redman, C. Fibrinogen Assembly and Secretion. ROLE OF INTRACHAIN DISULFIDE LOOPS. J. Biol. Chem. 271, 30083\u201330088 (1996).","journal-title":"J. Biol. Chem."},{"key":"BFsrep17259_CR19","doi-asserted-by":"publisher","first-page":"e17154","DOI":"10.1371\/journal.pone.0017154","volume":"6","author":"K Meijer","year":"2011","unstructured":"Meijer, K. et al. Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages. PloS one 6, e17154 (2011).","journal-title":"PloS one"},{"key":"BFsrep17259_CR20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0022-2275(20)41536-6","volume":"33","author":"JP Segrest","year":"1992","unstructured":"Segrest, J. P. et al. The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function. J. Lipid Res. 33, 141\u2013166 (1992).","journal-title":"J. Lipid Res."},{"key":"BFsrep17259_CR21","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1021\/bi0267184","volume":"42","author":"J Zdunek","year":"2003","unstructured":"Zdunek, J. et al. Global structure and dynamics of human apolipoprotein CII in complex with micelles: evidence for increased mobility of the helix involved in the activation of lipoprotein lipase. Biochem. 42, 1872\u20131889 (2003).","journal-title":"Biochem."},{"key":"BFsrep17259_CR22","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1093\/protein\/15.6.513","volume":"15","author":"L Lins","year":"2002","unstructured":"Lins, L. et al. Lipid-interacting properties of the N-terminal domain of human apolipoprotein C-III. Protein Eng. 15, 513\u2013520 (2002).","journal-title":"Protein Eng."},{"key":"BFsrep17259_CR23","doi-asserted-by":"publisher","first-page":"5645","DOI":"10.1073\/pnas.76.11.5645","volume":"76","author":"WL Vaz","year":"1979","unstructured":"Vaz, W. L., Jacobson, K., Wu, E. S. & Derzko, Z. Lateral mobility of an amphipathic apolipoprotein, ApoC-III, bound to phosphatidylcholine bilayers with and without cholesterol. Proceedings of the National Academy of Sciences of the United States of America 76, 5645\u20135649 (1979).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"BFsrep17259_CR24","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1073\/pnas.71.4.1534","volume":"71","author":"G Assmann","year":"1974","unstructured":"Assmann, G. & Brewer, H. B. A molecular model of high density lipoproteins. P. Natl. Acad. Sci. USA 71, 1534\u20131538 (1974).","journal-title":"P. Natl. Acad. Sci. USA"},{"key":"BFsrep17259_CR25","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1021\/ja107583h","volume":"133","author":"MP Monopoli","year":"2011","unstructured":"Monopoli, M. P. et al. Physical-chemical aspects of protein corona: relevance to in vitro and in vivo biological impacts of nanoparticles. J. Am. Chem. Soc. 133, 2525\u20132534 (2011).","journal-title":"J. Am. Chem. Soc."},{"key":"BFsrep17259_CR26","doi-asserted-by":"publisher","first-page":"5761","DOI":"10.1021\/ja910675v","volume":"132","author":"D Walczyk","year":"2010","unstructured":"Walczyk, D., Bombelli, F. B., Monopoli, M. P., Lynch, I. & Dawson, K. A. What the cell \u201csees\u201d in bionanoscience. J. Am. Chem. Soc. 132, 5761\u20135768 (2010).","journal-title":"J. Am. Chem. Soc."},{"key":"BFsrep17259_CR27","doi-asserted-by":"publisher","first-page":"215","DOI":"10.2217\/nnm.14.69","volume":"10","author":"M Mahmoudi","year":"2015","unstructured":"Mahmoudi, M. et al. Crucial role of the protein corona for the specific targeting of nanoparticles. Nanomedicine 10, 215\u2013226 (2015).","journal-title":"Nanomedicine"},{"key":"BFsrep17259_CR28","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.colsurfb.2014.09.009","volume":"123","author":"S Behzadi","year":"2014","unstructured":"Behzadi, S. et al. Protein corona change the drug release profile of nanocarriers: The \u201coverlooked\u201d factor at the nanobio interface. Colloids Surf. B Biointerfaces 123, 143\u2013149 (2014).","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"BFsrep17259_CR29","doi-asserted-by":"publisher","first-page":"5020","DOI":"10.1038\/srep05020","volume":"4","author":"U Sakulkhu","year":"2014","unstructured":"Sakulkhu, U., Mahmoudi, M., Maurizi, L., Salaklang, J. & Hofmann, H. Protein Corona Composition of Superparamagnetic Iron Oxide Nanoparticleswith Various Physico-Chemical Properties and Coatings. Sci. Rep. 4, 5020 (2014).","journal-title":"Sci. Rep."},{"key":"BFsrep17259_CR30","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1039\/C4BM00131A","volume":"4","author":"MJ Hajipour","year":"2014","unstructured":"Hajipour, M. J., Laurent, S., Aghaie, A., Rezaee, F. & Mahmoudi, M. Personalized protein coronas: a \u201ckey\u201d factor at the nanobiointerface. Biomater. Sci. 4, 1210\u20131221 (2014).","journal-title":"Biomater. Sci."},{"key":"BFsrep17259_CR31","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1021\/bi802205g","volume":"48","author":"JM Kollman","year":"2009","unstructured":"Kollman, J. M., Pandi, L., Sawaya, M. R., Riley, M. & Doolittle, R. F. Crystal structure of human fibrinogen. Biochem. 48, 3877\u20133886 (2009).","journal-title":"Biochem."},{"key":"BFsrep17259_CR32","doi-asserted-by":"publisher","first-page":"5491","DOI":"10.1021\/bi4007995","volume":"52","author":"JJ Marsh","year":"2013","unstructured":"Marsh, J. J. et al. Structural insights into fibrinogen dynamics using amide hydrogen\/deuterium exchange mass spectrometry. Biochem. 52, 5491\u20135502 (2013).","journal-title":"Biochem."},{"key":"BFsrep17259_CR33","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.jcis.2012.07.010","volume":"385","author":"Z Adamczyk","year":"2012","unstructured":"Adamczyk, Z. et al. Fibrinogen conformations and charge in electrolyte solutions derived from DLS and dynamic viscosity measurements. J. Colloid Interf. Sci. 385, 244\u2013257 (2012).","journal-title":"J. Colloid Interf. Sci."},{"key":"BFsrep17259_CR34","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.jcis.2013.01.007","volume":"395","author":"S Lousinian","year":"2013","unstructured":"Lousinian, S., Missopolinou, D. & Panayiotou, C. Fibrinogen adsorption on zinc oxide nanoparticles: a Micro-Differential Scanning Calorimetry analysis. J. Colloid Interf. Sci. 395, 294\u2013299 (2013).","journal-title":"J. Colloid Interf. Sci."},{"key":"BFsrep17259_CR35","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1126\/science.1214798","volume":"335","author":"E-P Ng","year":"2012","unstructured":"Ng, E.-P., Chateigner, D., Bein, T., Valtchev, V. & Mintova, S. Capturing ultrasmall EMT zeolite from template-free systems. Science 335, 70\u201373 (2012).","journal-title":"Science"},{"key":"BFsrep17259_CR36","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/nchem.1310","volume":"4","author":"J P\u00e9rez-Ram\u00edrez","year":"2012","unstructured":"P\u00e9rez-Ram\u00edrez, J. Zeolite nanosystems: Imagination has no limits. Nat. Chem. 4, 250\u2013251 (2012).","journal-title":"Nat. Chem."},{"key":"BFsrep17259_CR37","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.colsurfa.2005.05.001","volume":"264","author":"A Drechsler","year":"2005","unstructured":"Drechsler, A. & Grundke, K. The influence of electrolyte ions on the interaction forces between polystyrene surfaces. Colloid. Surface A 264, 157\u2013165 (2005).","journal-title":"Colloid. Surface A"},{"key":"BFsrep17259_CR38","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1002\/pmic.200500191","volume":"6","author":"F Rezaee","year":"2006","unstructured":"Rezaee, F., Casetta, B., Levels, J. H. M., Speijer, D. & Meijers, J. C. M. Proteomic analysis of high-density lipoprotein. Proteomics 6, 721\u2013730 (2006).","journal-title":"Proteomics"},{"key":"BFsrep17259_CR39","doi-asserted-by":"publisher","first-page":"6052","DOI":"10.1021\/pr100403q","volume":"9","author":"KCS Queiroz","year":"2010","unstructured":"Queiroz, K. C. S. et al. Human plasma very low density lipoprotein carries Indian hedgehog. J. Proteome Res. 9, 6052\u20136059 (2010).","journal-title":"J. Proteome Res."},{"key":"BFsrep17259_CR40","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1038\/srep02173","volume":"3","author":"S Sharifi","year":"2013","unstructured":"Sharifi, S. et al. Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes. Sci. Rep. 3, 2173 (2013).","journal-title":"Sci. Rep."},{"key":"BFsrep17259_CR41","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/MEG.0b013e3280101f7d","volume":"19","author":"S Klammt","year":"2007","unstructured":"Klammt, S. et al. Albumin-binding function is reduced in patients with decompensated cirrhosis and correlates inversely with severity of liver disease assessed by model for end-stage liver disease. Eur. J. Gastroenterol. Hepatol. 19, 257\u2013263 (2007).","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"BFsrep17259_CR42","doi-asserted-by":"publisher","first-page":"17416","DOI":"10.1074\/jbc.M800756200","volume":"283","author":"CS Gangabadage","year":"2008","unstructured":"Gangabadage, C. S. et al. Structure and dynamics of human apolipoprotein CIII. J. Biol. Chem. 283, 17416\u201317427 (2008).","journal-title":"J. Biol. Chem."},{"key":"BFsrep17259_CR43","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/nmat4173","volume":"14","author":"H Awala","year":"2015","unstructured":"Awala, H. et al. Template-free nanosized faujasite-type zeolites. Nat. Mater. 14, 447\u2013551 (2015).","journal-title":"Nat. Mater."},{"key":"BFsrep17259_CR44","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1021\/ac901816z","volume":"82","author":"X Shan","year":"2010","unstructured":"Shan, X. et al. Measuring surface charge density and particle height using surface plasmon resonance technique. Anal. Chem. 82, 234\u2013240 (2010).","journal-title":"Anal. Chem."},{"key":"BFsrep17259_CR45","doi-asserted-by":"publisher","first-page":"010587","DOI":"10.1074\/mcp.M111.016345","volume":"11","author":"J Zhang","year":"2012","unstructured":"Zhang, J. et al. PEAKS DB: de novo sequencing assisted database search for sensitive and accurate peptide identification. Mol. Cel. Proteomics 11, M111. 010587 (2012).","journal-title":"Mol. Cel. Proteomics"},{"key":"BFsrep17259_CR46","unstructured":"DeLano, W. L. The PyMOL Molecular Graphics System. Schr\u00f6dinger LLC www.pymolorg (Version 1.7.4.):http:\/\/www.pymol.org (2002)."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep17259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep17259","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep17259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T19:50:53Z","timestamp":1672948253000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep17259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,30]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12,22]]}},"alternative-id":["BFsrep17259"],"URL":"https:\/\/doi.org\/10.1038\/srep17259","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,30]]},"assertion":[{"value":"23 July 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The financial support from the Region of Lower Normandy, the Zeoxy project is acknowledged for financial support. The financial support from Erasmus Medical Center, Rotterdam, The Netherlands.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17259"}}