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The <jats:italic>SCNN1A<\/jats:italic> gene, which encodes the \u03b1-ENaC, might predispose infants to RDS. To explore whether the single-nucleotide polymorphisms (SNPs) of <jats:italic>SCNN1A<\/jats:italic> are associated with RDS, we conducted a case-control study to investigate the RDS-associated loci in Han Chinese infants. Seven target SNPs were selected from the <jats:italic>SCNN1A<\/jats:italic> gene and were genotyped using the improved multiplex ligase detection reaction (iMLDR). In the total sample, only rs4149570 was associated with NRDS; this association was further confirmed in logistic regression analysis after adjusting for birth weight, gestational age and sex. In the subgroup of infants whose gestational age was 37 weeks and older, in addition to rs4149570, rs7956915 also showed a significant association with RDS. Interestingly, these associations were only observed in term infants. No significant association was observed between the target SNPs and the risk of RDS in preterm infants. We report for the first time that the rs4149570 and rs7956915 polymorphisms of <jats:italic>SCNN1A<\/jats:italic> might play important roles in the susceptibility to RDS, particularly in term infants.<\/jats:p>","DOI":"10.1038\/srep17317","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T09:27:22Z","timestamp":1448616442000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Association of SCNN1A Single Nucleotide Polymorphisms with neonatal respiratory distress syndrome"],"prefix":"10.1038","volume":"5","author":[{"given":"Wang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Renjun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Zhangxue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wanwei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma","family":"Juan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,11,27]]},"reference":[{"key":"BFsrep17317_CR1","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1164\/ajrccm.164.7.2012126","volume":"164","author":"DC1 Angus","year":"2001","unstructured":"Angus, D. 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