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We hypothesized that rats preconditioned with an obesogenic diet would have better outcomes after surgical induction of short bowel syndrome compared to rats on regular chow. Rats were fed a high-fat diet or regular rat chow for six months and then underwent 50% proximal, 50% distal, or sham enterectomy. Food intake, weight and body composition were monitored before and for 4 weeks after surgery. The high-fat diet consistently produced obesity (&gt;25% body fat). All procedures induced weight loss, but there was no discernable difference between resection <jats:italic>vs<\/jats:italic>. sham resection. Rats on the high-fat diet had a greater post-resection loss of body fat compared to rats on chow (36 <jats:italic>vs<\/jats:italic>. 26\u2009g, respectively). There was a nonsignificant trend of less lean mass loss in the former compared to the latter rats (16 <jats:italic>vs<\/jats:italic>. 33\u2009g, respectively). Enterectomy moderated serum ghrelin, GIP, PPY, insulin and leptin. Intestinal adaptation was not different between obese <jats:italic>vs.<\/jats:italic> non-obese rats. Rats preconditioned with the high-fat diet may have had better retention of lean body mass after a surgical procedure compared to rats on chow. The effect of 50% enterectomy was less than expected.<\/jats:p>","DOI":"10.1038\/srep17331","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T10:22:54Z","timestamp":1448619774000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of proximal versus distal 50% enterectomy on nutritional parameters in rats preconditioned with a high-fat diet or regular chow"],"prefix":"10.1038","volume":"5","author":[{"given":"Ujwal R.","family":"Yanala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger D.","family":"Reidelberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon S.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie K.","family":"Shostrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,27]]},"reference":[{"key":"BFsrep17331_CR1","unstructured":"Thompson, J. 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