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However, <jats:italic>IFNG-AS1<\/jats:italic> contributing to Th1 cells\u2019 response in Hashimoto\u2019s thyroiditis (HT) patients has not been reported. Twenty-eight HT patients and 20 healthy controls were enrolled in the study. The proportion of circulating Th1 cells and the level of T-bet, <jats:italic>IFNG<\/jats:italic> mRNA were increased in HT patients, the expression of <jats:italic>IFNG-AS1<\/jats:italic> was upregulated and positively correlated with the proportion of circulating Th1 cells or T-bet and <jats:italic>IFNG<\/jats:italic> expression, or serum level of anti-thyroglobulin antibody\/thyroperoxidase antibody in HT patients. <jats:italic>IFNG-AS1<\/jats:italic> regulated the expression of <jats:italic>IFNG<\/jats:italic> at both transcriptional and translational level in human CD4<jats:sup>+<\/jats:sup> T cells. Furthermore, strong positive correlations between the increased transcript level of <jats:italic>IFNG-AS1<\/jats:italic> and the increased transcript level of T-bet or <jats:italic>IFNG<\/jats:italic> were revealed in thyroid tissues from HT patients. Our results indicate that enhanced expression of lncRNA-<jats:italic>IFNG-AS1<\/jats:italic> contributes to Th1 cell response in HT patients and may be involved in the pathogenesis of HT.<\/jats:p>","DOI":"10.1038\/srep17702","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T10:18:18Z","timestamp":1449224298000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["The Long Noncoding RNA IFNG-AS1 Promotes T Helper Type 1 Cells Response in Patients with Hashimoto\u2019s Thyroiditis"],"prefix":"10.1038","volume":"5","author":[{"given":"Huiyong","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Rui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoming","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,4]]},"reference":[{"key":"BFsrep17702_CR1","first-page":"1769","volume":"73","author":"A Bindra","year":"2006","unstructured":"Bindra, A. & Braunstein, G. 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