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Treating this disease by targeted or mass administration with a single chemical, praziquantel, carries the risk that drug resistance will develop in this pathogen. Therefore, there is an imperative to search for new drug targets in <jats:italic>S. haematobium<\/jats:italic> and other schistosomes. In this regard, protein kinases have potential, given their essential roles in biological processes and as targets for drugs already approved by the US Food and Drug Administration (FDA) for use in humans. In this context, we defined here the kinome of <jats:italic>S. haematobium<\/jats:italic> using a refined bioinformatic pipeline. We classified, curated and annotated predicted kinases and assessed the developmental transcription profiles of kinase genes. Then, we prioritised a panel of kinases as potential drug targets and inferred chemicals that bind to them using an integrated bioinformatic pipeline. Most kinases of <jats:italic>S. haematobium<\/jats:italic> are very similar to those of its congener, <jats:italic>S. mansoni<\/jats:italic>, offering the prospect of designing chemicals that kill both species. Overall, this study provides a global insight into the kinome of <jats:italic>S. haematobium<\/jats:italic> and should assist the repurposing or discovery of drugs against schistosomiasis.<\/jats:p>","DOI":"10.1038\/srep17759","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T10:02:18Z","timestamp":1449223338000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Defining the Schistosoma haematobium kinome enables the prediction of essential kinases as anti-schistosome drug targets"],"prefix":"10.1038","volume":"5","author":[{"given":"Andreas J.","family":"Stroehlein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil D.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron R.","family":"Jex","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Sternberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Boag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin B.","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,4]]},"reference":[{"key":"BFsrep17759_CR1","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","volume":"383","author":"DG Colley","year":"2014","unstructured":"Colley, D. 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