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Recently, the striatin-interacting phosphatase and kinase (STRIPAK) complex was revealed to be involved in diverse cellular processes. However, there is little evidence that STRIPAK components regulate microtubule dynamics, especially <jats:italic>in vivo<\/jats:italic>. Here, we show that one of the core STRIPAK components, Strip, is required for microtubule organization during neuronal morphogenesis. Knockdown of Strip causes a decrease in the level of acetylated \u03b1-tubulin in <jats:italic>Drosophila<\/jats:italic> S2 cells, suggesting that Strip influences the stability of microtubules. We also found that Strip physically and genetically interacts with tubulin folding cofactor D (TBCD), an essential regulator of \u03b1- and \u03b2-tubulin heterodimers. Furthermore, we demonstrate the genetic interaction between <jats:italic>strip<\/jats:italic> and <jats:italic>Down syndrome cell adhesion molecule<\/jats:italic> (<jats:italic>Dscam<\/jats:italic>), a cell surface molecule that is known to work with TBCD. Thus, we propose that Strip regulates neuronal morphogenesis by affecting microtubule stability.<\/jats:p>","DOI":"10.1038\/srep17769","type":"journal-article","created":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T11:08:51Z","timestamp":1449572931000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["A STRIPAK component Strip regulates neuronal morphogenesis by affecting microtubule stability"],"prefix":"10.1038","volume":"5","author":[{"given":"Chisako","family":"Sakuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misako","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Umehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Chihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,8]]},"reference":[{"key":"BFsrep17769_CR1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/0955-0674(94)90119-8","volume":"6","author":"N Hirokawa","year":"1994","unstructured":"Hirokawa, N. 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