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Graphitic carbon nitride coupled with bismuth sulfide are used as the sensing matrix for the immobilization of BSA-DXM on the electrode surface, while cadmium sulfide functionalized titanium dioxide (TiO<jats:sub>2<\/jats:sub>@CdS) is used as the photoelectric active labels of anti-DXM. Due to the perfect matching of energy levels between TiO<jats:sub>2<\/jats:sub> and CdS, the <jats:italic>in situ<\/jats:italic> prepared composite labels show excellent photocurrent response under visible lights. The competitive binding of DXM in sample solutions and BSA-DXM on the electrode surface reduces the specific attachment of labels to the electrode, resulting in a decrease of the photocurrent intensity. Greatly enhanced sensitivity is achieved after the optimization of the detection conditions. Under the optimal detection condition, the well-designed immunosensor for DXM exhibits a low detection limit of 2\u2009pg\u2219mL<jats:sup>\u22121<\/jats:sup>. 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