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In the present study, we investigated hematopoiesis in adult <jats:italic>Fancb<\/jats:italic> deficient (<jats:italic>Fancb<\/jats:italic><jats:sup><jats:italic>\u2212\/y<\/jats:italic><\/jats:sup>) mice and found that <jats:italic>Fancb<\/jats:italic><jats:sup><jats:italic>\u2212\/y<\/jats:italic><\/jats:sup> mice have decreased hematopoietic stem cell (HSC) quiescence accompanied by reduced progenitor activity <jats:italic>in vitro<\/jats:italic> and reduced repopulating capacity <jats:italic>in vivo<\/jats:italic>. Like other FA mouse models previously reported, the hematopoietic system of <jats:italic>Fancb<\/jats:italic><jats:sup><jats:italic>\u2212\/y<\/jats:italic><\/jats:sup> mice is hypersensitive to DNA cross-linking agent mitomycin C (MMC), which induces bone marrow failure in <jats:italic>Fancb<\/jats:italic><jats:sup><jats:italic>\u2212\/y<\/jats:italic><\/jats:sup> mice. Furthermore, <jats:italic>Fancb<\/jats:italic><jats:sup><jats:italic>\u2212\/y<\/jats:italic><\/jats:sup> BM exhibits slower recovery kinetics and less tolerance to myelotoxic stress induced by 5-fluorouracil than wild-type littermates. RNA-seq analysis reveals altered expression of genes involved in HSC function and cell cycle regulation in <jats:italic>Fancb<\/jats:italic><jats:sup><jats:italic>\u2212\/y<\/jats:italic><\/jats:sup> HSC and progenitor cells. Thus, this <jats:italic>Fancb<\/jats:italic><jats:sup><jats:italic>\u2212\/y<\/jats:italic><\/jats:sup> mouse model provides a novel approach for studying the critical role of the FA pathway not only in germ cell development but also in the maintenance of HSC function.<\/jats:p>","DOI":"10.1038\/srep18127","type":"journal-article","created":{"date-parts":[[2015,12,11]],"date-time":"2015-12-11T11:33:37Z","timestamp":1449833617000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Fancb deficiency impairs hematopoietic stem cell function"],"prefix":"10.1038","volume":"5","author":[{"given":"Wei","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya","family":"Amarachintha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Erden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amom Ruhikanta","family":"Meetei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Andreassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi H.","family":"Namekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qishen","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,11]]},"reference":[{"key":"BFsrep18127_CR1","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1182\/blood-2014-04-526293","volume":"124","author":"S Longerich","year":"2014","unstructured":"Longerich, S., Li, J., Xiong, Y., Sung, P. & Kupfer, G. 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