{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T19:08:31Z","timestamp":1781118511585,"version":"3.54.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T00:00:00Z","timestamp":1452124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T00:00:00Z","timestamp":1452124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic aberrations in tumor driver genes provide specific molecular targets for therapeutic intervention, which can greatly improve therapeutic outcomes. Here, we analyzed the mutational frequency of <jats:italic>EGFR<\/jats:italic> and <jats:italic>KRAS<\/jats:italic> gene, as well as <jats:italic>EML4-ALK<\/jats:italic> rearrangement and summarized the clinicopathological characters of Chinese lung cancer patients. We detected the mutation spectrum of 1033 primary lung cancer patients. The analyzed clinicopathological parameters included gender, age at diagnosis, smoking status, pathological TNM stage, tumor morphology and location, visceral pleural invasion and histological type. A total of 618 patients had mutations in <jats:italic>EGFR<\/jats:italic> or <jats:italic>KRAS<\/jats:italic> gene as well as rearrangement of <jats:italic>EML4-ALK<\/jats:italic>. Exon 19 deletions and L858R in the <jats:italic>EGFR<\/jats:italic> gene were the most frequent mutations. Left-side lung cancer was more common in female patients carrying the <jats:italic>KRAS<\/jats:italic> mutation. Rearrangement of <jats:italic>EML4-ALK<\/jats:italic> was more common in non-tobacco-using male patients, who also exhibited a higher likelihood of visceral pleura invasion. Elderly females who never smoked and possessed 1\u201320\u2009mm stage I adenocarcinomas in the right side exhibited a higher frequency of <jats:italic>EGFR<\/jats:italic> mutations. Elderly male smokers with right lung tumors were viable candidates for <jats:italic>KRAS<\/jats:italic> mutation screening.<\/jats:p>","DOI":"10.1038\/srep18566","type":"journal-article","created":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T10:26:19Z","timestamp":1452162379000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Elderly male smokers with right lung tumors are viable candidates for KRAS mutation screening"],"prefix":"10.1038","volume":"6","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gening","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,7]]},"reference":[{"key":"BFsrep18566_CR1","unstructured":"Jie, H., Ping, Z. & Wanqing, C. 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