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In a <jats:italic>Drosophila<\/jats:italic> model of HD, expression of mutant Huntingtin (Htt) protein with expanded polyQ leads to formation of inclusion bodies (IBs), increase in cellular toxicity, progression of motor disabilities and reduced viability. Multiple cellular events such as oxidative stress, mitochondrial dysfunction, inflammation and transcriptional dysregulation are reported to contribute to pathology, however, till date there are no disease-modifying treatments with least side effects. Therefore, we investigated effect of the phytochemical curcumin on HD pathogenesis. Curcumin, a phytochemical and commonly used ingredient in Asian food has a wide spectrum of anti-oxidant, anti-inflammatory and anti-fibrilogenic properties. In this study, we provide evidence that curcumin significantly ameliorates disease symptoms in a <jats:italic>Drosophila<\/jats:italic> model of HD by suppressing cell death and can be a key to halting the progression of Huntington\u2019s disease with least side effects.<\/jats:p>","DOI":"10.1038\/srep18736","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T11:03:28Z","timestamp":1451991808000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Curcumin modulates cell death and is protective in Huntington\u2019s disease model"],"prefix":"10.1038","volume":"6","author":[{"given":"Anjalika","family":"Chongtham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namita","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,5]]},"reference":[{"issue":"6","key":"BFsrep18736_CR1","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"M MACDONALD","year":"1993","unstructured":"The Huntington\u2019s Disease Collaborative Research Group. 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