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The selective detection of H<jats:sub>2<\/jats:sub>S in living systems is essential for studying its functions. Fluorescence detection methods have become useful tools to explore the physiological roles of H<jats:sub>2<\/jats:sub>S because of their real-time and non-destructive characteristics. Herein we report a near-infrared fluorescent probe, NIR-HS, capable of tracking H<jats:sub>2<\/jats:sub>S in living organisms. With high sensitivity, good selectivity and low cytotoxicity, NIR-HS was able to recognize both the exogenous and endogenous H<jats:sub>2<\/jats:sub>S in living cells. More importantly, it realized the visualization of endogenous H<jats:sub>2<\/jats:sub>S generated in cells overexpressing cystathionine \u03b2-synthase (CBS), one of the enzymes responsible for producing endogenous H<jats:sub>2<\/jats:sub>S. The probe was also successfully applied to detect both the exogenous and endogenous H<jats:sub>2<\/jats:sub>S in living mice. The superior sensing properties of the probe render it a valuable research tool in the H<jats:sub>2<\/jats:sub>S-related medical research.<\/jats:p>","DOI":"10.1038\/srep18868","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T11:28:24Z","timestamp":1452252504000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["A highly selective and sensitive near-infrared fluorescent probe for imaging of hydrogen sulphide in living cells and mice"],"prefix":"10.1038","volume":"6","author":[{"given":"Ling","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi Emily","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanguo","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,8]]},"reference":[{"key":"BFsrep18868_CR1","doi-asserted-by":"publisher","first-page":"21903","DOI":"10.1074\/jbc.R110.128363","volume":"285","author":"O Kabil","year":"2010","unstructured":"Kabil, O. & Banerjee, R. 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