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However, to date, no research has focused on the effect of humidex on hand, foot and mouth disease (HFMD). The current study was designed to address this research need. Case-based HFMD surveillance data and daily meteorological data collected between 2010 and 2012 was obtained from the China CDC and the National Meteorological Information Center, respectively. Distributed lag nonlinear models were applied to assess the impact of humidex on HFMD among children under 15 years oldin Guangdong and its variability across social-economic status and age groups. We found that relative risk (<jats:italic>RR)<\/jats:italic> largely increased with humidex. Lag-specific and cumulative humidex-<jats:italic>RR<\/jats:italic> curves for children from the Pearl-River Delta Region as well as older children were more likely to show two-peak distribution patterns. One <jats:italic>RR<\/jats:italic> peak occurred at a humidex of between 15 and 20 and the other occurred between 30 and 35. This study provides a comprehensive picture of the impact of humidex on HFMD incidence in Guangdong Province. Results from the present study should be important in the development of area-and-age-targeted control programs.<\/jats:p>","DOI":"10.1038\/srep18965","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T11:20:14Z","timestamp":1452252014000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Assessing the impact of humidex on HFMD in Guangdong Province and its variability across social-economic status and age groups"],"prefix":"10.1038","volume":"6","author":[{"given":"Wangjian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuantao","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,8]]},"reference":[{"key":"BFsrep18965_CR1","unstructured":"China CDC. 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