{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:08:11Z","timestamp":1790730491069,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T00:00:00Z","timestamp":1452211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T00:00:00Z","timestamp":1452211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glaucoma is not only an eye disease but is also associated with degeneration of brain structures. We now investigated the pattern of visual and non-visual brain structural changes in 25 primary open angle glaucoma (POAG) patients and 25 age-gender-matched normal controls using T1-weighted imaging. MRI images were subjected to volume-based analysis (VBA) and surface-based analysis (SBA) in the whole brain as well as ROI-based analysis of the lateral geniculate nucleus (LGN), visual cortex (V1\/2), amygdala and hippocampus. While VBA showed no significant differences in the gray matter volumes of patients, SBA revealed significantly reduced cortical thickness in the right frontal pole and ROI-based analysis volume shrinkage in LGN bilaterally, right V1 and left amygdala. Structural abnormalities were correlated with clinical parameters in a subset of the patients revealing that the left LGN volume was negatively correlated with bilateral cup-to-disk ratio (CDR), the right LGN volume was positively correlated with the mean deviation of the right visual hemifield and the right V1 cortical thickness was negatively correlated with the right CDR in glaucoma. These results demonstrate that POAG affects both vision-related structures and non-visual cortical regions. Moreover, alterations of the brain visual structures reflect the clinical severity of glaucoma.<\/jats:p>","DOI":"10.1038\/srep18969","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T11:20:18Z","timestamp":1452252018000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Structural brain alterations in primary open angle glaucoma: a 3T MRI study"],"prefix":"10.1038","volume":"6","author":[{"given":"Jieqiong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard A.","family":"Sabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diya","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfang","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiguang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,8]]},"reference":[{"key":"BFsrep18969_CR1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0161-6420(02)01564-6","volume":"110","author":"V Guedes","year":"2003","unstructured":"Guedes, V. et al. Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes. Ophthalmology 110, 177\u2013189, doi: 10.1016\/S0161-6420(02)01564-6 (2003).","journal-title":"Ophthalmology"},{"key":"BFsrep18969_CR2","doi-asserted-by":"publisher","first-page":"e295","DOI":"10.1111\/j.1755-3768.2011.02346.x","volume":"90","author":"YQ Zhang","year":"2012","unstructured":"Zhang, Y. Q. et al. Anterior visual pathway assessment by magnetic resonance imaging in normal-pressure glaucoma. Acta ophthalmologica 90, e295\u2013302, doi: 10.1111\/j.1755-3768.2011.02346.x (2012).","journal-title":"Acta ophthalmologica"},{"key":"BFsrep18969_CR3","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1167\/iovs.12-9893","volume":"54","author":"WW Chen","year":"2013","unstructured":"Chen, W. W. et al. Structural brain abnormalities in patients with primary open-angle glaucoma: a study with 3T MR imaging. Investigative ophthalmology & visual science 54, 545\u2013554, doi: 10.1167\/iovs.12-9893 (2013).","journal-title":"Investigative ophthalmology & visual science"},{"key":"BFsrep18969_CR4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1001\/archopht.121.1.41","volume":"121","author":"DS Greenfield","year":"2003","unstructured":"Greenfield, D. S., Bagga, H. & Knighton, R. W. Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography. Arch Ophthalmol-Chic 121, 41\u201346 (2003).","journal-title":"Arch Ophthalmol-Chic"},{"key":"BFsrep18969_CR5","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ajo.2004.08.069","volume":"139","author":"FA Medeiros","year":"2005","unstructured":"Medeiros, F. A. et al. Evaluation of retinal nerve fiber layer, optic nerve head and macular thickness measurements for glaucoma detection using optical coherence tomography. Am J Ophthalmol 139, 44\u201355, doi: 10.1016\/j.ajo.2004.08.069 (2005).","journal-title":"Am J Ophthalmol"},{"key":"BFsrep18969_CR6","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1136\/bjo.2005.086769","volume":"90","author":"N Gupta","year":"2006","unstructured":"Gupta, N., Ang, L. C., de Tilly, L. N., Bidaisee, L. & Yucel, Y. H. Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus and visual cortex. Brit J Ophthalmol 90, 674\u2013678, doi: 10.1136\/bjo.2005.086769 (2006).","journal-title":"Brit J Ophthalmol"},{"key":"BFsrep18969_CR7","doi-asserted-by":"crossref","unstructured":"Hui, E. S., Fu, Q. L., So, K. F. & Wu, E. X. Diffusion tensor MR study of optic nerve degeneration in glaucoma. P Ann Int Ieee Embs, 4312\u20134315, doi: 10.1109\/Iembs.2007.4353290 (2007).","DOI":"10.1109\/IEMBS.2007.4353290"},{"key":"BFsrep18969_CR8","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1148\/radiol.2522081240","volume":"252","author":"FG Garaci","year":"2009","unstructured":"Garaci, F. G. et al. Optic Nerve and Optic Radiation Neurodegeneration in Patients with Glaucoma: In Vivo Analysis with 3-T Diffusion-Tensor MR Imaging. Radiology 252, 496\u2013501, doi: 10.1148\/radiol.2522081240 (2009).","journal-title":"Radiology"},{"key":"BFsrep18969_CR9","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.acra.2011.01.014","volume":"18","author":"T Engelhorn","year":"2011","unstructured":"Engelhorn, T. et al. Diffusion Tensor Imaging Detects Rarefaction of Optic Radiation in Glaucoma Patients. Academic radiology 18, 764\u2013769, doi: 10.1016\/j.acra.2011.01.014 (2011).","journal-title":"Academic radiology"},{"key":"BFsrep18969_CR10","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.preteyeres.2006.10.001","volume":"26","author":"RO Duncan","year":"2007","unstructured":"Duncan, R. O., Sample, P. A., Weinreb, R. N., Bowd, C. & Zangwill, L. M. Retinotopic organization of primary visual cortex in glaucoma: Comparing fMRI measurements of cortical function with visual field loss. Progress in retinal and eye research 26, 38\u201356, doi: 10.1016\/j.preteyeres.2006.10.001 (2007).","journal-title":"Progress in retinal and eye research"},{"key":"BFsrep18969_CR11","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/Icu.0b013e3280895aea","volume":"18","author":"N Gupta","year":"2007","unstructured":"Gupta, N. & Yucel, Y. H. Glaucoma as a neurodegenerative disease. Curr Opin Ophthalmol 18, 110\u2013114, doi: 10.1097\/Icu.0b013e3280895aea (2007).","journal-title":"Curr Opin Ophthalmol"},{"key":"BFsrep18969_CR12","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1097\/IJG.0b013e31829349bf","volume":"22","author":"JB Jonas","year":"2013","unstructured":"Jonas, J. B., Yang, D. & Wang, N. Intracranial pressure and glaucoma. Journal of glaucoma 22 Suppl 5, S13\u201314, doi: 10.1097\/IJG.0b013e31829349bf (2013).","journal-title":"Journal of glaucoma"},{"key":"BFsrep18969_CR13","doi-asserted-by":"publisher","first-page":"e84","DOI":"10.1111\/aos.12330","volume":"93","author":"Z Zhang","year":"2015","unstructured":"Zhang, Z. et al. Intracranial pressure fluctuations: a potential risk factor for glaucoma? Acta ophthalmologica 93, e84\u201385, doi: 10.1111\/aos.12330 (2015).","journal-title":"Acta ophthalmologica"},{"key":"BFsrep18969_CR14","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3129\/i08-059","volume":"43","author":"YH Yucel","year":"2008","unstructured":"Yucel, Y. H. & Gupta, N. Paying attention to the cerebrovascular system in glaucoma. Canadian journal of ophthalmology. Journal canadien d\u2019ophtalmologie 43, 342\u2013346, doi: 10.3129\/i08-059 (2008).","journal-title":"Canadian journal of ophthalmology. Journal canadien d\u2019ophtalmologie"},{"key":"BFsrep18969_CR15","doi-asserted-by":"publisher","first-page":"794","DOI":"10.3109\/02713683.2012.683506","volume":"37","author":"C Li","year":"2012","unstructured":"Li, C. et al. Voxel-based morphometry of the visual-related cortex in primary open angle glaucoma. Current eye research 37, 794\u2013802, doi: 10.3109\/02713683.2012.683506 (2012).","journal-title":"Current eye research"},{"key":"BFsrep18969_CR16","doi-asserted-by":"publisher","first-page":"5880","DOI":"10.1167\/iovs.13-11776","volume":"54","author":"AL Williams","year":"2013","unstructured":"Williams, A. L. et al. Evidence for widespread structural brain changes in glaucoma: a preliminary voxel-based MRI study. Investigative ophthalmology & visual science 54, 5880\u20135887, doi: 10.1167\/iovs.13-11776 (2013).","journal-title":"Investigative ophthalmology & visual science"},{"key":"BFsrep18969_CR17","doi-asserted-by":"publisher","first-page":"e73208","DOI":"10.1371\/journal.pone.0073208","volume":"8","author":"L Yu","year":"2013","unstructured":"Yu, L. et al. Reduced cortical thickness in primary open-angle glaucoma and its relationship to the retinal nerve fiber layer thickness. PloS one 8, e73208, doi: 10.1371\/journal.pone.0073208 (2013).","journal-title":"PloS one"},{"key":"BFsrep18969_CR18","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","volume":"26","author":"J Ashburner","year":"2005","unstructured":"Ashburner, J. & Friston, K. J. Unified segmentation. Neuroimage 26, 839\u2013851, doi: 10.1016\/j.neuroimage.2005.02.018 (2005).","journal-title":"Neuroimage"},{"key":"BFsrep18969_CR19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","volume":"38","author":"J Ashburner","year":"2007","unstructured":"Ashburner, J. A fast diffeomorphic image registration algorithm. Neuroimage 38, 95\u2013113, doi: 10.1016\/j.neuroimage.2007.07.007 (2007).","journal-title":"Neuroimage"},{"key":"BFsrep18969_CR20","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.neuroimage.2004.03.032","volume":"22","author":"F Segonne","year":"2004","unstructured":"Segonne, F. et al. A hybrid approach to the skull stripping problem in MRI. Neuroimage 22, 1060\u20131075, doi: 10.1016\/j.neuroimage.2004.03.032 (2004).","journal-title":"Neuroimage"},{"key":"BFsrep18969_CR21","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/nimg.1998.0395","volume":"9","author":"AM Dale","year":"1999","unstructured":"Dale, A. M., Fischl, B. & Sereno, M. I. Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage 9, 179\u2013194, doi: 10.1006\/nimg.1998.0395 (1999).","journal-title":"Neuroimage"},{"key":"BFsrep18969_CR22","doi-asserted-by":"publisher","first-page":"11050","DOI":"10.1073\/pnas.200033797","volume":"97","author":"B Fischl","year":"2000","unstructured":"Fischl, B. & Dale, A. M. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proceedings of the National Academy of Sciences of the United States of America 97, 11050\u201311055, doi: 10.1073\/pnas.200033797 (2000).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"BFsrep18969_CR23","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1176\/appi.neuropsych.12020030","volume":"25","author":"A Agorastos","year":"2013","unstructured":"Agorastos, A. et al. Depression, anxiety and disturbed sleep in glaucoma. The Journal of neuropsychiatry and clinical neurosciences 25, 205\u2013213, doi: 10.1176\/appi.neuropsych.12020030 (2013).","journal-title":"The Journal of neuropsychiatry and clinical neurosciences"},{"key":"BFsrep18969_CR24","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jpsychores.2013.03.005","volume":"75","author":"C Zhou","year":"2013","unstructured":"Zhou, C., Qian, S., Wu, P. & Qiu, C. Anxiety and depression in Chinese patients with glaucoma: sociodemographic, clinical and self-reported correlates. Journal of psychosomatic research 75, 75\u201382, doi: 10.1016\/j.jpsychores.2013.03.005 (2013).","journal-title":"Journal of psychosomatic research"},{"key":"BFsrep18969_CR25","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1097\/Ijg.0b013e3182071b7e","volume":"21","author":"BP Yochim","year":"2012","unstructured":"Yochim, B. P., Mueller, A. E., Kane, K. D. & Kahook, M. Y. Prevalence of Cognitive Impairment, Depression and Anxiety Symptoms Among Older Adults With Glaucoma. Journal of glaucoma 21, 250\u2013254, doi: 10.1097\/Ijg.0b013e3182071b7e (2012).","journal-title":"Journal of glaucoma"},{"key":"BFsrep18969_CR26","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1093\/cercor\/bhm225","volume":"18","author":"B Fischl","year":"2008","unstructured":"Fischl, B. et al. Cortical folding patterns and predicting cytoarchitecture. Cereb Cortex 18, 1973\u20131980, doi: 10.1093\/cercor\/bhm225 (2008).","journal-title":"Cereb Cortex"},{"key":"BFsrep18969_CR27","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","volume":"33","author":"B Fischl","year":"2002","unstructured":"Fischl, B. et al. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33, 341\u2013355 (2002).","journal-title":"Neuron"},{"key":"BFsrep18969_CR28","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jneumeth.2015.08.006","volume":"255","author":"J Wang","year":"2015","unstructured":"Wang, J. et al. Automatic segmentation of the lateral geniculate nucleus: Application to control and glaucoma patients. Journal of neuroscience methods 255, 104\u2013114, doi: 10.1016\/j.jneumeth.2015.08.006 (2015).","journal-title":"Journal of neuroscience methods"},{"key":"BFsrep18969_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00235642","volume":"63","author":"SM Sherman","year":"1986","unstructured":"Sherman, S. M. & Koch, C. The Control of Retinogeniculate Transmission in the Mammalian Lateral Geniculate-Nucleus. Experimental Brain Research 63, 1\u201320 (1986).","journal-title":"Experimental Brain Research"},{"key":"BFsrep18969_CR30","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1152\/jn.1993.70.3.909","volume":"70","author":"BC Motter","year":"1993","unstructured":"Motter, B. C. Focal Attention Produces Spatially Selective Processing in Visual Cortical Areas V1, V2 and V4 in the Presence of Competing Stimuli. Journal of neurophysiology 70, 909\u2013919 (1993).","journal-title":"Journal of neurophysiology"},{"key":"BFsrep18969_CR31","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1152\/jn.1997.77.1.24","volume":"77","author":"SJ Luck","year":"1997","unstructured":"Luck, S. J., Chelazzi, L., Hillyard, S. A. & Desimone, R. Neural mechanisms of spatial selective attention in areas V1, V2 and V4 of macaque visual cortex. Journal of neurophysiology 77, 24\u201342 (1997).","journal-title":"Journal of neurophysiology"},{"key":"BFsrep18969_CR32","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nn1008","volume":"6","author":"ER Sowell","year":"2003","unstructured":"Sowell, E. R. et al. Mapping cortical change across the human life span. Nature neuroscience 6, 309\u2013315, doi: 10.1038\/nn1008 (2003).","journal-title":"Nature neuroscience"},{"key":"BFsrep18969_CR33","doi-asserted-by":"publisher","first-page":"3586","DOI":"10.1523\/JNEUROSCI.5309-07.2008","volume":"28","author":"P Shaw","year":"2008","unstructured":"Shaw, P. et al. Neurodevelopmental trajectories of the human cerebral cortex. J Neurosci 28, 3586\u20133594, doi: 10.1523\/JNEUROSCI.5309-07.2008 (2008).","journal-title":"J Neurosci"},{"key":"BFsrep18969_CR34","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s11517-013-1131-9","volume":"52","author":"JQ Wang","year":"2014","unstructured":"Wang, J. Q. et al. Age estimation using cortical surface pattern combining thickness with curvatures. Med Biol Eng Comput 52, 331\u2013341, doi: 10.1007\/s11517-013-1131-9 (2014).","journal-title":"Med Biol Eng Comput"},{"key":"BFsrep18969_CR35","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/j.1469-8749.2008.02026.x","volume":"50","author":"I Dumontheil","year":"2008","unstructured":"Dumontheil, I., Burgess, P. W. & Blakemore, S. J. Development of rostral prefrontal cortex and cognitive and behavioural disorders. Dev Med Child Neurol 50, 168\u2013181, doi: 10.1111\/j.1469-8749.2008.02026.x (2008).","journal-title":"Dev Med Child Neurol"},{"key":"BFsrep18969_CR36","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.neuroimage.2004.02.029","volume":"22","author":"GD Waiter","year":"2004","unstructured":"Waiter, G. D. et al. A voxel-based investigation of brain structure in male adolescents with autistic spectrum disorder. Neuroimage 22, 619\u2013625, doi: 10.1016\/j.neuroimage.2004.02.029 (2004).","journal-title":"Neuroimage"},{"key":"BFsrep18969_CR37","doi-asserted-by":"publisher","first-page":"s1140","DOI":"10.2741\/1172","volume":"8","author":"SJ McKinnon","year":"2003","unstructured":"McKinnon, S. J. Glaucoma: ocular Alzheimer\u2019s disease? Frontiers in bioscience : a journal and virtual library 8, s1140\u20131156 (2003).","journal-title":"Frontiers in bioscience : a journal and virtual library"},{"key":"BFsrep18969_CR38","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.tics.2011.02.001","volume":"15","author":"S Tsujimoto","year":"2011","unstructured":"Tsujimoto, S., Genovesio, A. & Wise, S. P. Frontal pole cortex: encoding ends at the end of the endbrain. Trends Cogn Sci 15, 169\u2013176, doi: 10.1016\/j.tics.2011.02.001 (2011).","journal-title":"Trends Cogn Sci"},{"key":"BFsrep18969_CR39","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.tics.2011.04.005","volume":"15","author":"E Koechlin","year":"2011","unstructured":"Koechlin, E. Frontal pole function: what is specifically human? Trends Cogn Sci 15, 241\u2013241, doi: 10.1016\/j.tics.2011.04.005 (2011).","journal-title":"Trends Cogn Sci"},{"key":"BFsrep18969_CR40","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0002-9394(01)01196-5","volume":"133","author":"AU Bayer","year":"2002","unstructured":"Bayer, A. U., Keller, O. N., Ferrari, F. & Maag, K. P. Association of glaucoma with neurodegenerative diseases with apoptotic cell death: Alzheimer\u2019s disease and Parkinson\u2019s disease. Am J Ophthalmol 133, 135\u2013137 (2002).","journal-title":"Am J Ophthalmol"},{"key":"BFsrep18969_CR41","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.cortex.2015.03.020","volume":"67","author":"M Bola","year":"2015","unstructured":"Bola, M., Gall, C. & Sabel, B. A. Disturbed temporal dynamics of brain synchronization in vision loss. Cortex; a journal devoted to the study of the nervous system and behavior 67, 134\u2013146, doi: 10.1016\/j.cortex.2015.03.020 (2015).","journal-title":"Cortex; a journal devoted to the study of the nervous system and behavior"},{"key":"BFsrep18969_CR42","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1212\/WNL.0000000000000672","volume":"83","author":"M Bola","year":"2014","unstructured":"Bola, M. et al. Brain functional connectivity network breakdown and restoration in blindness. Neurology 83, 542\u2013551, doi: 10.1212\/WNL.0000000000000672 (2014).","journal-title":"Neurology"},{"key":"BFsrep18969_CR43","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/30976","volume":"393","author":"JS Morris","year":"1998","unstructured":"Morris, J. S., Ohman, A. & Dolan, R. J. Conscious and unconscious emotional learning in the human amygdala. Nature 393, 467\u2013470, doi: 10.1038\/30976 (1998).","journal-title":"Nature"},{"key":"BFsrep18969_CR44","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1146\/annurev.neuro.23.1.155","volume":"23","author":"JE LeDoux","year":"2000","unstructured":"LeDoux, J. E. Emotion circuits in the brain. Annu Rev Neurosci 23, 155\u2013184, doi: 10.1146\/annurev.neuro.23.1.155 (2000).","journal-title":"Annu Rev Neurosci"},{"key":"BFsrep18969_CR45","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1101\/lm.30901","volume":"8","author":"HT Blair","year":"2001","unstructured":"Blair, H. T., Schafe, G. E., Bauer, E. P., Rodrigues, S. M. & LeDoux, J. E. Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning. Learning & memory 8, 229\u2013242, doi: 10.1101\/lm.30901 (2001).","journal-title":"Learning & memory"},{"key":"BFsrep18969_CR46","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1037\/\/0033-295x.94.2.148","volume":"94","author":"SMSeeing Kosslyn","year":"1987","unstructured":"Kosslyn, S. M. Seeing and Imagining in the Cerebral Hemispheres-a Computational Approach. Psychol Rev 94, 148\u2013175, doi: 10.1037\/\/0033-295x.94.2.148 (1987).","journal-title":"Psychol Rev"},{"key":"BFsrep18969_CR47","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.neuroimage.2009.06.043","volume":"48","author":"C Hutton","year":"2009","unstructured":"Hutton, C., Draganski, B., Ashburner, J. & Weiskopf, N. A comparison between voxel-based cortical thickness and voxel-based morphometry in normal aging. Neuroimage 48, 371\u2013380, doi: 10.1016\/j.neuroimage.2009.06.043 (2009).","journal-title":"Neuroimage"},{"key":"BFsrep18969_CR48","doi-asserted-by":"crossref","unstructured":"Lemaitre, H. et al. Normal age-related brain morphometric changes: nonuniformity across cortical thickness, surface area and gray matter volume? Neurobiology of aging 33, doi: 10.1016\/.neurobiolaging.2010.07.013 (2012).","DOI":"10.1016\/j.neurobiolaging.2010.07.013"},{"key":"BFsrep18969_CR49","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.acra.2012.03.006","volume":"19","author":"XJ Long","year":"2012","unstructured":"Long, X. J. et al. Healthy Aging: An Automatic Analysis of Global and Regional Morphological Alterations of Human Brain. Academic radiology 19, 785\u2013793, doi: 10.1016\/j.acra.2012.03.006 (2012).","journal-title":"Academic radiology"},{"key":"BFsrep18969_CR50","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.tics.2011.08.005","volume":"15","author":"EH de Haan","year":"2011","unstructured":"de Haan, E. H. & Cowey, A. On the usefulness of \u2018what\u2019 and \u2018where\u2019 pathways in vision. Trends Cogn Sci 15, 460\u2013466, doi: 10.1016\/j.tics.2011.08.005 (2011).","journal-title":"Trends Cogn Sci"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep18969.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep18969","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep18969.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T06:29:26Z","timestamp":1672900166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep18969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,8]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,5,10]]}},"alternative-id":["BFsrep18969"],"URL":"https:\/\/doi.org\/10.1038\/srep18969","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,8]]},"assertion":[{"value":"22 June 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18969"}}