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As potential protective agents, some polysaccharides were shown to have anti-tumor, anti-inflammatory and\/or anti-oxidant properties. This study explored potential effects of oral treatment of <jats:italic>Dioscorea bulbifera<\/jats:italic> polysaccharides (DBLP at 100 or 150\u2009mg\/kg) in U14 cervical tumor-bearing mice treated with CTX (25\u2009mg\/kg). While CTX suppressed tumor growth (65.4% inhibition) and DBLP alone also inhibited tumor (25.6% at 100\u2009mg\/kg or 37.6% at 150\u2009mg\/kg), CTX+DBLP combination produced tumor inhibition rates of 5.6 (for 100\u2009mg\/kg DBLP) or 9% (for 150\u2009mg\/kg) higher than CTX alone. While tumor itself and CTX treatment reduced thymus and\/or spleen\/body weight indices, DBLP alone or CTX\u2009+\u2009DBLP combination attenuated this reduction. DBLP lowered peripheral blood T-cell subpopulation CD<jats:sup>4+<\/jats:sup>\/CD<jats:sup>8+<\/jats:sup> ratio and DBLP+CTX combination attenuated CTX effect in lifting CD<jats:sup>4+<\/jats:sup>\/CD<jats:sup>8+<\/jats:sup> ratio. Tumor itself and CTX treatment heightened oxidative stress (with decreased superoxide dismutase but increased lactate dehydrogenase and malondialdehyde levels in serum and tissues), which was attenuated by DBLP treatment and DBLP+CTX combination suppressed CTX-induced oxidative stress. Combination use of DBLP with CTX can potentially enhance CTX anti-tumor effect and can attenuate CTX-induced immunosuppression and oxidative stress in U14 cervical tumor-bearing mice.<\/jats:p>","DOI":"10.1038\/srep19185","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T10:28:08Z","timestamp":1452594488000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Dioscorea bulbifera polysaccharide and cyclophosphamide combination enhances anti-cervical cancer effect and attenuates immunosuppression and oxidative stress in mice"],"prefix":"10.1038","volume":"6","author":[{"given":"Hongxia","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory J.","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,12]]},"reference":[{"key":"BFsrep19185_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.20138","volume":"62","author":"R Siegel","year":"2012","unstructured":"Siegel, R., Naishadham, D. & Jemal, A. 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