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There is considered to be a high potential for autologous transplantation of human dental pulp stem cells (DPSCs) in endodontic treatment. The usefulness of DPSCs isolated from healthy teeth is limited. However, DPSCs isolated from diseased teeth with irreversible pulpitis (IP-DPSCs) are considered to be suitable for dentin\/pulp regeneration. In this study, we examined the stem cell potency of IP-DPSCs. In comparison with healthy DPSCs, IP-DPSCs expressed lower colony-forming capacity, population-doubling rate, cell proliferation, multipotency, <jats:italic>in vivo<\/jats:italic> dentin regeneration and immunosuppressive activity, suggesting that intact IP-DPSCs may be inadequate for dentin\/pulp regeneration. Therefore, we attempted to improve the impaired <jats:italic>in vivo<\/jats:italic> dentin regeneration and <jats:italic>in vitro<\/jats:italic> immunosuppressive functions of IP-DPSCs to enable dentin\/pulp regeneration. Interferon gamma (IFN-\u03b3) treatment enhanced <jats:italic>in vivo<\/jats:italic> dentin regeneration and <jats:italic>in vitro<\/jats:italic> T cell suppression of IP-DPSCs, whereas treatment with tumor necrosis factor alpha did not. Therefore, these findings suggest that IFN-\u03b3 may be a feasible modulator to improve the functions of impaired IP-DPSCs, suggesting that autologous transplantation of IFN-\u03b3-accelerated IP-DPSCs might be a promising new therapeutic strategy for dentin\/pulp tissue engineering in future endodontic treatment.<\/jats:p>","DOI":"10.1038\/srep19286","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T12:03:56Z","timestamp":1453118636000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells"],"prefix":"10.1038","volume":"6","author":[{"given":"Soichiro","family":"Sonoda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruyoshi","family":"Yamaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Tomoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reona","family":"Aijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Nonaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Kukita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusanori","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Yamaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,18]]},"reference":[{"key":"BFsrep19286_CR1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.14219\/jada.archive.2000.0175","volume":"131","author":"PE Murray","year":"2000","unstructured":"Murray, P. 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