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In this study, we investigated the association of 13 SNPs for these genes with Beh\u00e7et\u2019s disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome using a polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay. Haplotype and linkage disequilibrium (LD) analysis were performed by Haploview4.2. IRF8 mRNA expression and cytokine production was tested by real-time PCR and ELISA. Two SNPs near IRF8 were associated with BD (for rs17445836 GG genotype, Pc\u2009=\u20099.56\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>, OR\u2009=\u20092.044; for rs11642873 AA genotype, Pc\u2009=\u20099.24\u2009\u00d7\u200910<jats:sup>\u22127<\/jats:sup>, OR\u2009=\u20091.776). No significant association was found for the 13 SNPs tested with VKH syndrome. Haplotype analysis of the two positive SNPs revealed that the AG haplotype was significantly increased in BD patients (Pc\u2009=\u20092.60\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>, OR\u2009=\u20091.646). Functional studies revealed an increased mRNA expression of IRF8 and IFN-\u03b3 production and a decreased production of IL-10 in rs17445836 carriers with the GG genotype. Increased expression of IRF8 as well as IFN-\u03b3 production and a decreased production of IL-10 were found in individuals carrying the rs11642873\/AA genotype. In conclusion, this study indicates that IRF8 may contribute to the genetic susceptibility of BD by regulating IRF8 expression and cytokine production.<\/jats:p>","DOI":"10.1038\/srep19651","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T10:12:36Z","timestamp":1453457556000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Two Genetic Variations in the IRF8 region are associated with Beh\u00e7et\u2019s disease in Han Chinese"],"prefix":"10.1038","volume":"6","author":[{"given":"Yanni","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongsong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dengfeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengping","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aize","family":"Kijlstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peizeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,1,22]]},"reference":[{"key":"BFsrep19651_CR1","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00281-014-0433-9","volume":"36","author":"RW Lee","year":"2014","unstructured":"Lee, R. 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