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However, achieving regioselective C-H activation is a great challenge because C-H bonds are ubiquitous in organic compounds. Actually, the regioselective couplings promoted by enzymes are a common occurrence in nature. Herein, we have developed simple, efficient and general transition metal-free intramolecular couplings of alphatic and aromatic C-H bonds. The protocol uses readily available aryl triazene as the radical initiator, cheap K<jats:sub>2<\/jats:sub>S<jats:sub>2<\/jats:sub>O<jats:sub>8<\/jats:sub> as the oxidant and the couplings were performed well with excellent tolerance of functional groups. Interestingly, \u03b1-carbon configuration of some amino acid residues in the substrates was kept after the reactions and the couplings for substrates with substituted phenylalanine residues exhibited complete \u03b2-carbon diastereoselectivity for induction of the chiral \u03b1-carbon. Therefore, the present study should provide a novel strategy for regioselective cross-dehydrogenative couplings of two different C-H bonds.<\/jats:p>","DOI":"10.1038\/srep19931","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T10:52:49Z","timestamp":1454064769000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Transition metal-free intramolecular regioselective couplings of aliphatic and aromatic C-H bonds"],"prefix":"10.1038","volume":"6","author":[{"given":"Hua","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changjin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,1,29]]},"reference":[{"key":"BFsrep19931_CR1","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1021\/cr0509760","volume":"107","author":"D Alberico","year":"2007","unstructured":"Alberico, D., Scott, M. 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