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Although the exact etiology of CPT is highly debated, 40\u201380% of CPT patients are carriers of a mutation in the <jats:italic>Neurofibromatosis Type 1<\/jats:italic> (<jats:italic>NF1<\/jats:italic>) gene, which can potentially result in an altered phenotype of the skeletal cells and impaired bone healing. In this study we use a computational model of bone regeneration to examine the effect of the <jats:italic>Nf1<\/jats:italic> mutation on bone fracture healing by altering the parameter values of eight key factors which describe the aberrant cellular behaviour of <jats:italic>Nf1<\/jats:italic> haploinsufficient and <jats:italic>Nf1<\/jats:italic> bi-allelically inactivated cells. We show that the computational model is able to predict the formation of a hamartoma as well as a wide variety of CPT phenotypes through different combinations of altered parameter values. A sensitivity analysis by \u201cDesign of Experiments\u201d identified the impaired endochondral ossification process and increased infiltration of fibroblastic cells as key contributors to the degree of severity of CPT. Hence, the computational model results have added credibility to the experimental hypothesis of a genetic cause (i.e. <jats:italic>Nf1<\/jats:italic> mutation) for CPT.<\/jats:p>","DOI":"10.1038\/srep20010","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T11:06:58Z","timestamp":1454065618000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Capturing the wide variety of impaired fracture healing phenotypes in Neurofibromatosis Type 1 with eight key factors: a computational study"],"prefix":"10.1038","volume":"6","author":[{"given":"A.","family":"Carlier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Brems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M. 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The error has been fixed in the paper.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2017","order":7,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Erratum","order":8,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Scientific Reports 6: Article number: 20010; published online: 29 January 2016; updated: 30 June 2017. The original HTML version of this Article listed an incorrect volume number. 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