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Very little is known on the metabolism of this bacterium and its impact on the host. In this study, we have revealed the importance of the glutamate-generating metabolism, as shown by a complete depletion of glutamine (Gln) in the medium during <jats:italic>H. suis<\/jats:italic> culture. Besides Gln, <jats:italic>H. suis<\/jats:italic> can also convert glutathione (GSH) to glutamate and both reactions are catalyzed by the <jats:italic>H. suis<\/jats:italic> \u03b3-glutamyltranspeptidase (GGT). Both for <jats:italic>H. pylori<\/jats:italic> and <jats:italic>H. suis<\/jats:italic>, it has been hypothesized that the degradation of Gln and GSH may lead to a deficiency for the host, possibly initiating or promoting several pathologies. Therefore the <jats:italic>in vivo<\/jats:italic> effect of oral supplementation with Gln and GSH was assessed. Oral supplementation with Gln was shown to temper <jats:italic>H. suis<\/jats:italic> induced gastritis and epithelial (hyper)proliferation in Mongolian gerbils. Astonishingly, supplementation of the feed with GSH, another GGT substrate, resulted in inflammation and epithelial proliferation levels returning to baseline levels of uninfected controls. This indicates that Gln and GSH supplementation may help reducing tissue damage caused by <jats:italic>Helicobacter<\/jats:italic> infection in both humans and pigs, highlighting their potential as a supportive therapy during and after <jats:italic>Helicobacter<\/jats:italic> eradication therapy.<\/jats:p>","DOI":"10.1038\/srep20169","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T11:36:39Z","timestamp":1454412999000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Oral glutathione supplementation drastically reduces Helicobacter-induced gastric pathologies"],"prefix":"10.1038","volume":"6","author":[{"given":"Ellen","family":"De Bruyne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ducatelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Foss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrthe","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke","family":"Smet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Pasmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Haesebrouck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bram","family":"Flahou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,2]]},"reference":[{"key":"BFsrep20169_CR1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1128\/CMR.00041-08","volume":"22","author":"F Haesebrouck","year":"2009","unstructured":"Haesebrouck, F. et al. 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